Clinical trials: Therapeutic Community
Breast Cancer
Treatment Patterns and Clinical Outcomes Among Patients With HR+/HER2- mBC Receiving Palbociclib Combination Therapy in the US Community Oncology Setting.
By leveraging a community-based, cancer-specific electronic healthcare record for this study, we aim to understand treatment patterns and clinical outcomes among patients with HR+/HER2- mBC who received care within the context of…
- Trial name
- NCT04460911
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Pfizer
Pneumonia
Reducing Cost of Azythromycin by Transferring From IV to Oral Therapy
Intravenous Azythromycin therapy is considerably more expensive than oral therapy. The investigators believe that intravenous therapy is prolonged more that necessary and that oral therapy can be used much earlier in the course…
- Trial name
- NCT01741909
- Testing
- education
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Community-associated Infections, Health-care Acquired Infections
Optimal Antibiotic Treatment of Moderate to Severe Bacterial Infections
Severe bacterial infections are associated with mortality of about 30%. Patients with moderate to severe bacterial infections given early and appropriate empirical antibiotic treatment are at a lesser risk for a fatal outcome…
- Conditions
- Community-associated Infections, Health-care Acquired Infections, Nosocomial Infections
- Trial name
- CDSS (NCT01338116)
- Testing
- antibiotic treatment of by TREAT/PCR
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Mental Health, Community Health Workers
Khanya Ekhaya: A Home-Based Intervention
Mental health conditions, such as depression, anxiety, and harmful alcohol use are prevalent among people with chronic diseases, including HIV, and contribute to poor engagement in care.
- Conditions
- Mental Health, Community Health Workers, Training, Global Health
- Trial name
- NCT06985641
- Testing
- Khanya-Ekhaya
- Where
- South Africa
- Volunteers
- 119 people
- Sponsor
- University of Maryland, College Park
Accidental Falls
The Effectiveness of a Self-managed Digital Exercise Programme to Prevent Falls in Older Community-dwelling People
The overall aim of the study is to evaluate the effectiveness of a digital self-management exercise program in preventing falls in community dwelling older people.
- Trial name
- SafeStepRCT (NCT03963570)
- Testing
- Safe Step - digital exercise program, Control group
- Where
- Sweden
- Volunteers
- 1,628 people
- Sponsor
- Umeå University
Substance Use Disorders, Comorbidities and Coexisting Conditions
Adaptation of Community Reinforcement Approach for the Treatment of Drug Addiction
Central idea of the study is to adapt a treatment program for drug addiction treatment indigenously and relapse prevention, and to establish its efficacy.
- Trial name
- NCT06559631
- Testing
- Indigenously Adapted CRA
- Where
- 2 sites in Pakistan
- Volunteers
- 59 people
- Sponsor
- Muhammad Saghir
Hypertension, Cardiovascular Disease
Pilot Study of Home Blood Pressure Control Program (eBP Control)
This intervention study will evaluate the feasibility,acceptability and effectiveness of an e-health enabled model of care by randomly assigning a trained patient navigator and/or a blood pressure (BP) self-management web portal…
- Trial name
- eBPcontrol (NCT01387945)
- Testing
- HBPM+website+patient navigator
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Memorial Hospital of Rhode Island
Overweight, Obesity
The Additive Effect of Cognitive Behavioral Treatment (CBT) to Conventional Weight Loss Intervention Program for Young Adults With Intellectual Disabilities
In this randomized case control study we will evaluate the additive effect of psychological intervention, i.e CBT-cognitive behavioral treatment in a multi-strategy weight loss program composed of physical activity intervention…
- Conditions
- Overweight, Obesity, Learning Disability
- Trial name
- NCT01032369
- Testing
- Nutritional intervention and physical activity, Nutritional intervention, physical activity and behavioral treatment
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pneumonia
Study to Compare the Efficacy of Pristinamycin (Pyostacine ®) Versus Amoxicillin in the Treatment of Acute Community Acquired Pneumonia
Primary Objective: To evaluate the clinical efficacy of pristinamycin at a dose of 2g x 2/day for 2 days then 1g x 3/day for 5 to 7 days versus amoxicillin 1g x3 /day for 7 to 9 days, 5 to 9 days after the end of treatment.
- Trial name
- NCT02332577
- Testing
- PRISTINAMYCIN XRP7263, Amoxicillin
- Where
- 19 sites in France, Tunisia
- Volunteers
- 161 people
- Sponsor
- Sanofi
Community Reinforcement And Family Training, Family Health
Scalable Digital Delivery of Evidence-based Training for Family to Maximize Treatment Admission Rates of Opioid Use Disorder in Loved Ones
The United States is in the midst of an opioid crisis. Over-prescription of opioid analgesic pain relievers contributed to a rapid escalation of use and misuse of these substances across the country.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT05666856
- Testing
- Community Reinforcement And Family Training, We The Village Peer Community Forum
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Community-acquired Bacterial Pneumonia
Efficacy and Safety Study of Oral Solithromycin (CEM-101) Compared to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia
This study will evaluate the safety and efficacy of an experimental antibiotic, solithromycin, in the treatment of adult patients with community-acquired pneumonia.
- Trial name
- SOLITAIRE-ORAL (NCT01756339)
- Testing
- Solithromycin, Moxifloxacin
- Where
- 119 sites in United States, Argentina and 15 more
- Volunteers
- 860 people
- Sponsor
- Melinta Therapeutics, Inc.
Depression
Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)
This study is a randomized Type I hybrid effectiveness-implementation trial aimed at evaluating the effectiveness of Empower@Home, an internet-delivered cognitive-behavioral therapy (CBT) program supported by aging service…
- Trial name
- NCT06584422
- Testing
- Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of Michigan
Pneumocystis Jiroveci Pneumonia
Corticosteroids for PJP in Non-HIV Immunocompromised Adults
Pneumocystis jirovecii pneumonia (PJP) is one of the common severe complications in immunocompromised patients, with a reported mortality rate of 60-80%.
- Trial name
- CAPSTONE-PJP (NCT07152613)
- Testing
- Saline (0.9%, sterile, for infusion), Low Dose Corticosteroids, Moderate dose corticosteroids
- Volunteers
- 240 people
- Sponsor
- Qingyuan Zhan
Depression, Diabetes
Effectiveness of a Mobile Technology Intervention for the Treatment of Depression
Background: Depression is a usual comorbid event associated to chronic diseases, such as hypertension and diabetes, constituting an important public health problem, with negative consequences for patients' quality of life and…
- Conditions
- Depression, Diabetes, Hypertension
- Trial name
- Latin-MH (NCT02846662)
- Testing
- CONEMO
- Where
- Brazil
- Volunteers
- 880 people
- Sponsor
- University of Sao Paulo General Hospital
COVID-19, Vaccine Refusal
CATCH-UP Vaccines: Engaged Approaches to Testing in Community/Healthcare Settings for the Underserved (COVID-19)
Oklahoma has high COVID-19 incidence, particularly among underserved minority and rural Oklahomans. Oklahoman's are also reporting SARS-CoV-2 vaccine hesitancy and signs of slowing vaccine uptake, with increased hesitancy among…
- Trial name
- NCT05236270
- Testing
- Text Message, Motivational Interviewing, Electronic Educational Message with Tailored Questions/Prompts
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Schizophrenia, Schizophreniform Disorder
Integrated Care in Psychotic Disorders With Severe Mental Illness
The study examine the effectiveness of an integrated care program including therapeutic assertive community treatment (ACT) for people with psychotic disorders fulfilling severe and persistent mental illness (SPMI, ACCESS-II…
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder, Delusional Disorder
- Trial name
- ACCESS-II (NCT01888627)
- Testing
- Integrated care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Patient Participation
Electronic Health Record Strategies to Promote Diverse Participation in Research
The purpose of this study is to determine the effectiveness of enhanced features in an online patient portal including banners, a chatbot, and direct to patient message and traditional mailed letters on increasing interest in…
- Trial name
- NCT05348603
- Testing
- Traditional Letter, Direct to Patient Message, Chatbot
- Where
- United States
- Volunteers
- 726,199 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV Infections, Adherence, Medication
Technology Based Community Health Nursing to Improve Combination Anti-Retroviral Therapy (cART) Adherence and Virologic Suppression in Youth Living With HIV
Human immunodeficiency virus (HIV) infection has disproportionately persisted as a public health threat to adolescents and young adults (AYA) from minority communities in the United States.
- Trial name
- Tech2Check (NCT03600103)
- Testing
- Tech2Check
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- Johns Hopkins University
Atrial Arrhythmia, Cardiovascular Diseases
Treatment of Atrial Fibrillation in the Community Settings
Description of treatment of cardiovascular diseases in community settings in Russia
- Trial name
- NCT06151132
- Testing
- Direct current cardioversion
- Volunteers
- 430 people
- Sponsor
- ITMO University
Chronic Low-back Pain, Older Adults
Core Stabilization Exercise Therapy in Chronic Lower Back Back Management in Community Dwelling Older Adults
Objectives: To develop an exercise program for older adults with low back pain. And,to develop a clinical prediction rule that could identify a subgroup of people with NSLBP Participants: 150 people aged between 40 to 80 with…
- Conditions
- Chronic Low-back Pain, Older Adults, Core Stabilization Exercise Therapy
- Trial name
- NCT06030128
- Testing
- core stabilization exercise
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The Hong Kong Polytechnic University