Clinical trials: Therapeutic Endoscopy
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults…
- Trial name
- NCT07798219
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Diabetes Mellitus, Type 2
A Trial to Evaluate Safety, Feasibility and Efficacy of Endoscopic Duodenal PEF Therapy
The objective of this study is to evaluate the safety, feasibility and efficacy of pulsed electric field induced duodenal mucosal regeneration (with the Endogenex System en Gen 2 Device) combined with a GLP-1 receptor agonist…
- Trial name
- EMINENT-2 (NCT05984238)
- Testing
- PEF therapy using the Endogenex Device, Semaglutide, 1.0 mg/mL
- Where
- Netherlands
- Volunteers
- 33 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Crohn's Disease
The Effect on Mucosal Healing With Pentasa Sachet in Mild to Moderate Active "Drug: Crohn's Disease"
The purpose of this study is to visualize the healing effect on mucosal lesions with Pentasa Sachet 4g in patients with mild to moderate active small bowel CD by video capsule endoscopy.
- Trial name
- NCT00245505
- Testing
- Mesalazine (Mesalamine)
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Endotracheal Intubation, Gastrointestinal Endoscopy
Application of Lateral Position Digestive Endoscopy-Guided Endotracheal Intubation in Anesthesia for Endoscopic Diagnosis and Therapy
This case series study evaluated whether placing a breathing tube using a camera (gastrointestinal endoscope) is safe and effective for patients lying on their left side during stomach and intestine exams under anesthesia.
- Conditions
- Endotracheal Intubation, Gastrointestinal Endoscopy, Airway Management, Lateral Position
- Trial name
- NCT06990490
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Changlong Qiao
Gastroesophageal Reflux Disease
Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease
The goal of this randomized clinical trial is to investigate the efficacy and safety of antireflux mucosal ablation (ARMA) for patients with refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT06106100
- Testing
- Antireflux mucosal ablation
- Volunteers
- 68 people
- Sponsor
- Far Eastern Memorial Hospital
Pancreatic Cancer
EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)
This is a single arm study in the treatment of pancreatic ductal adenocarcinoma (PDAC). The investigators propose to test the tolerability of chemotherapy plus endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) using…
- Trial name
- NCT05723107
- Testing
- Chemotherapy, Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Choledocholithiasis, Large Common Bile Duct Stone
Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones
Bile duct stone extraction is impossible after endoscopic sphincterotomy (ES) alone in approximatively 10% of cases (mostly because of stones' size).
- Trial name
- NCT02592811
- Testing
- ERCP, Endoscopic Sphincterotomy, Large Balloon Dilatation of Oddi Sphincter
- Volunteers
- 150 people
- Sponsor
- Société Française d'Endoscopie Digestive
GI Bleeding
High Dose Oral Omeprazole in High Risk UGIB
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding.
- Trial name
- NCT04394663
- Testing
- High-dose oral omeprazole, Standard IV PPI
- Where
- 2 sites in Thailand
- Volunteers
- 128 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Laryngeal Neoplasms
KTP vs CO2 Laser for the Treatment of Laryngeal Carcinoma
comparison results of treatment of early stage glottic cancer between two methods of surgical treatment - CO2 laser and KTP laser
- Trial name
- NCT02672904
- Testing
- CO2 laser, KTP laser
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Kaplan Medical Center
Adenomatous Polyposis Coli, Familial Adenomatous Polyposis
Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis
The objective of this study is to investigate the feasibility for the treatment of precancerous peri-ampullary FAP polyps in the duodenum using low-thermal argonplasma.
- Conditions
- Adenomatous Polyposis Coli, Familial Adenomatous Polyposis, Duodenal Adenoma
- Trial name
- coldAPC (NCT06435533)
- Testing
- low energy argonplasma coagulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
High-risk Patients With Acute Calculous Cholecystitis (ACC)
Surgical vs Endoscopic Treatments as ImmunoModulating Interventions in High-Risk Acute Calculous Cholecystitis
Randomized controlled trial on high-risk patients with ACC. Consecutive patients with a diagnosis of ACC, if they meet the inclusion and exclusion criteria, will be randomized to receive Laparoscopic cholecystectomy (LC) or…
- Trial name
- SETIMIHRACC (NCT06918652)
- Testing
- Transmural ultrasound-guided gallbladder drainage, Laparoscopic cholecystectomy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Diabetes, Diabetes Type 2
Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes
This is a multi-center, open-label study to assess the feasibility and preliminary safety of the Endogenex Device for endoscopic duodenal mucosal regeneration in patients with type 2 Diabetes inadequately controlled on 2-3…
- Conditions
- Diabetes, Diabetes Type 2, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- REGENT-1-US (NCT05014204)
- Testing
- The Endogenex Device
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endogenex, Inc.
Obesity, Obesity, Morbid
Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis.
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Metabolic Disease
- Trial name
- PSAM (NCT05711758)
- Testing
- PSAM Treatment Patients
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Esophageal Stricture
Mitomycin-C Injection Therapy in Refractory Esophageal Stricture
Intralesional Mitomycin-C (MMC) injection has recently been introduced to resolve refractory benign esophageal stricture mostly in children.
- Trial name
- NCT04284826
- Testing
- Endoscopic injection of Mitomycin-C on bougie-dilated refractory benign esophageal stricture
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Ajou University School of Medicine
Crohn Disease
Endoscopic Balloon Dilation vs Surgery to Treat Short Strictures in Fibrostenosing Crohns Disease: An RCT
There is currently no standard management to guide the clinicians in treating patients with fibrostenotic disease. European Crohns and Colitis Organization [ECCO] recently developed a topical review on prediction, diagnosis and…
- Trial name
- NCT03735355
- Testing
- Surgery, TTS balloon dilation
- Volunteers
- 40 people
- Sponsor
- McMaster University
Obesity
ENDObesity® II Study: TransPyloric Shuttle® System for Weight Loss
The purpose of this clinical research trial is to study safety and effectiveness of the TransPyloric Shuttle System (TPSS) for weight reduction in patients who are considered medically obese.
- Trial name
- NCT02518685
- Testing
- TransPyloric Shuttle, Lifestyle Counseling
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- BaroNova, Inc.
Fistula, Regenerative Medicine
RESTOREGI Study: Regenerative Endoscopic Stromal Therapy: Outcomes and Risk Factor Evaluation in GI Fistulas
RESTOREGI Study Benign gastrointestinal fistulas are abnormal communications between the gastrointestinal tract and adjacent organs or the skin.
- Conditions
- Fistula, Regenerative Medicine, Stromal Vascular Fraction
- Trial name
- RESTORE-GI (NCT07661043)
- Testing
- Endoscopic tSVF-EM Therapy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Adenoma Colon, Serrated Polyp
Cold EMR Vs Standard EMR for the Treatment of Large Nonpedunculated Homogeneous Colorectal Lesions
This study compares the effectiveness in complete resection (absence of recurrence at 6 months) the two different techniques for performing endoscopic mucosal resection (EMR) of nonpedunculated homogeneous colorectal lesions >20mm
- Conditions
- Adenoma Colon, Serrated Polyp, Serrated Adenoma, Colorectal Neoplasms
- Trial name
- NCT04418843
- Testing
- Standard Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Spain
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Oscar Nogales
Colonic Polyp
Cold Snare Polypectomy Versus. Endoscopic Mucosal Resection
The investigators will investigate the efficacy of EMR compared to CSP in treatment of small colon polp (6~10mm). One aim of this study was to investigate the necessity of EMR on resection of small colon polyp.
- Trial name
- NCT02476747
- Testing
- EMR, CSP
- Where
- South Korea
- Volunteers
- 103 people
- Sponsor
- Asan Medical Center
ERCP, Robot Surgery
Efficacy and Safety of a Novel ERCP Robot in the Treatment of Common Bile Duct Stone
Conventional endoscopic retrograde cholangiopancreatography (ERCP) is performed under fluoroscopic guidance, exposing endoscopists to ionizing radiation and posing risks of work-related musculoskeletal injury.
- Conditions
- ERCP, Robot Surgery, Common Bile Duct Stone
- Trial name
- ERCP (NCT07368335)
- Testing
- Robotic-assisted ERCP, Conventional ERCP
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School