Clinical trials: Therapeutic Endoscopy
Pancreatic Cancer
EUS Guided Neurolysis Celiac Block w/wo Bupivacaine in Patient Being Treated Palliatively for Pancreatic Cancer
The goal of this project is to determine if EUS-CPN without Bupivacaine (versus EUS-CPN with Bupivacaine) can reduce pain scores and improve quality of life in patients with inoperable pancreatic cancer by reducing the morbidity…
- Trial name
- EUS-CPN (NCT02682082)
- Testing
- Endoscopic ultrasound-guided celiax plexus neurolysis, Bupivacaine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Gastrointestinal Submucosal Tumors
Evaluation of Short-term and Long-term Efficacy of Endoscopic Treatment for Gastrointestinal Submucosal Tumors
This study aims to comprehensively assess how well endoscopic treatments work for gastrointestinal submucosal tumors (SMTs)-both in the short term right after treatment and over the long run-and to figure out what factors might…
- Trial name
- NCT07353346
- Volunteers
- 700 people
- Sponsor
- Xijing Hospital
Gastric Cancer
Phase III Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Patients with early gastric cancer, who require therapeutic upper gastrointestinal endoscopy, such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), will receive intragastric spraying of NPO-11 or…
- Trial name
- NCT01411176
- Testing
- Menthol
- Where
- Japan
- Volunteers
- 85 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Colorectal Cancer
Endoscopic Treatment of Inoperable Colorectal Cancer With the EndoVe System
A new approach to treating solid tumours (both operable and inoperable) has been carried out by the Cork Cancer Research Centre (CCRC) at the Mercy University Hospital, Cork, Ireland since 2002.
- Trial name
- CCEE EndoVe (NCT01172860)
- Testing
- EndoVe endoscopic electroporation
- Where
- Ireland
- Volunteers
- 10 people
- Sponsor
- Mercy University Hospital, Cork, Ireland
Locally Advanced Pancreatic Cancer
Endoscopic Ultrasound-Guided Loco-regional Chemotherapy Injection as Adjuvant Therapy for Locally Advanced Pancreatic Cancer.
this is a randomized controlled trial aims to compare between patients with locally advanced pancreatic cancer treated with EUS-guided injection of gemcitabine in addition to systemic chemotherapy, versus those who treated with…
- Trial name
- NCT07429643
- Testing
- endoscopic ultrasonograhy guided chemptherapy injection
- Volunteers
- 20 people
- Sponsor
- Assiut University
Early Gastric Cancer, Endoscopic Submucosal Dissection
The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma
This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide…
- Trial name
- NCT05323929
- Testing
- ESD
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cholangiopancreatography, Endoscopic Retrograde, Pancreatitis
Tailored Hydration for the Prevention of Post-ERCP Pancreatitis
Aggressive hydration of lactated Ringer's solution has shown considerable beneficial effect in preventing post-ERCP(endoscopic retrograde cholangiopancreatography) pancreatitis.
- Trial name
- NCT03561441
- Testing
- Tailored aggressive hydration, Tailored standard hydration
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Chonnam National University Hospital
Gastroesophageal Reflux Disease
Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
The aims of this study are to create a prospective data base to evaluate the long term outcomes of medical and surgical treatment of gastroesophageal reflux disease (GERD); to measure standard outcomes as well as patient derived…
- Trial name
- NCT00260572
- Testing
- Questionnaires to evaluate QOL, Questionnaires to evaluate heartburn and quality of life, Questionnaire to evaluate satisfaction with treatment
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- University of Pittsburgh
Music Therapy
EFFECTS OF MUSIC THERAPY DURING ENDOSCOPY ON PAIN, ANXIETY AND VITAL SIGNS
This study was conducted to evaluate the effect of music therapy on the vital signs, anxiety and pain of the patients during endoscopy procedure
- Trial name
- MUSCOPY (NCT06756919)
- Testing
- Music intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara Yildirim Beyazıt University
Patients, Sinusitis
The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
The treatment of eosinophilic sinusitis with nasal polyps is difficult and challenging. After endoscopic sinus surgery(ESS), complications such as edema, scar formation, adhesions, sinus stenosis and recurrence of polyps are…
- Conditions
- Patients, Sinusitis, Nasal Polyps
- Trial name
- NCT03943121
- Testing
- Steroid-eluting stent implant, Without Steroid-eluting stent implant
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing Tongren Hospital
Gastroparesis
GPOEM Versus SHAM as a Treatement of Gastroparesis
Objectives: To evaluate the efficacy of gastric per oral endoscopic pyloromyotomy (G-POEM) in the treatment of gastroparesis. Endpoints Primary endpoint: Clinical Efficacy Will be assessed by measurements of Gastroparesis…
- Trial name
- GPOEMvsSHAM (NCT04552184)
- Testing
- GPOEM
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Erasme University Hospital
Pancreatic Pseudocyst
Natural Orifice Translumenal Endoscopic Surgery (NOTES) Cystgastrostomy for the Treatment of Pancreatic Pseudocysts
Natural Orifice Translumenal Endoscopic Surgery (NOTES) describes a new field of investigational surgery which uses the endoscope as the primary operative tool.
- Trial name
- NCT00541593
- Testing
- Pancreatic Pseudocystgastrostomy
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Type 2 Diabetes Mellitus (T2DM)
Endoscopic Band Ligation for Type 2 Diabetes Mellitus (ENDOBAND-DM)
This is a pilot clinical study evaluating the safety and feasibility of Endoscopic Band Ligation (ENDOBAND-DM) applied to the second through fourth parts of the duodenum - from just distal to the ampulla of Vater to the ligament…
- Trial name
- ENDOBAND-DM (NCT07117721)
- Testing
- Endoscopic Band Ligation (ENDOBAND-DM)
- Volunteers
- 10 people
- Sponsor
- El Katib Hospital
Chronic Rhinosinusitis
Canadian Health Economics, Outcome, and Effectiveness Comparison of Treatment in Patients With Chronic Rhinosinusitis
The economic, patient related outcome, and effectiveness of balloon sinuplasty in the treatment of CRS patients with frontal and other sinus disease in the Canadian healthcare environment is not known at this time.
- Trial name
- CHEC (NCT01455948)
- Testing
- Relieva Balloon Sinuplasty™ System, Functional Endoscopic Sinus Surgery
- Where
- 8 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Integra LifeSciences Corporation
Idiopathic Normal Pressure Hydrocephalus (INPH)
Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal…
- Trial name
- NCT06488248
- Testing
- Endoscopic third ventriculostomy (ETV), Ventriculoperitoneal shunt (VPS)
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Crohn's Disease, Inflammatory Bowel Diseases
Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease
This study will evaluate the response of itraconazole and terbinafine therapy compared to placebo in patients with mild to moderate Crohn's disease (CD).
- Trial name
- CD-IT (NCT05049525)
- Testing
- Itraconazole 400 mg/day and terbinafine 500 mg/day administered orally.
- Where
- 4 sites in Canada
- Volunteers
- 16 people
- Sponsor
- Montreal Heart Institute
Obesity, Obesity, Morbid
Endoscopic Gastric Mucosal Devitalization (GMD) as a Primary Obesity Therapy - Part 2
Rapid metabolic improvements seen with sleeve gastrectomy are likely a result of changes in gastric origin. The gastric mucosa is an endocrine organ that regulates satiation pathways and is a complex regulator of food intake as…
- Conditions
- Obesity, Obesity, Morbid, Obesity; Endocrine, Bariatric Surgery Candidate
- Trial name
- NCT03638843
- Testing
- Gastric mucosal devitalization
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cholangiopancreatography, Endoscopic Retrograde
EUS-guided Entero-biliary Anastomosis for Therapeutic Access in Benign Biliary Obstructions
Background: Transpapillary EUS-BD (rendezvous/antegrade) is gaining acceptance in BBO. The potential of transmural EUS-BD (hepaticogastrostomy/choledochoduodenostomy) in complex BBO warrants study.
- Trial name
- ATENHEA (NCT05246657)
- Testing
- EUS-guided Entero-biliary Anastomosis
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital del Rio Hortega
Ulcerative Colitis
Association Between Effectiveness of Mirikizumab and UC Patients With High Neutrophilic Infiltration in Epithelium of the Colonic Mucosa
The goal of this study is to confirm that Mirikizumab therapy may provide clinical, endoscopic, and histopathologic improvements in patients with moderate to severe UC refractory to maintenance therapy when high neutrophilic…
- Trial name
- NCT06626165
- Testing
- Mirikizumab, Vedolizumab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Showa Inan General Hospital