Clinical trials: Therapeutic Endoscopy
Submucosal Tumor of Stomach
Submucosal Tumor Removal by Endoscopic Excision Therapy
Smaller submucosal tumors (SMT) in the stomach are usually seen as an incidental finding during a gastroscopy, although current diagnostics usually do not clearly indicate what type of tumor it is.
- Trial name
- STREET (NCT04913077)
- Testing
- removal of submucosal gastric tumor preferably by Full Thickness Resection Device (FTRD)
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Upper Gastrointestinal Bleeding, Tumor Bleeding
Over-the-scope Clips and Standard Treatments in Endoscopic Control of Acute Bleeding From Non-variceal Upper GI Causes
In the management of patients with acute upper gastrointestinal bleeding from non-variceal causes, endoscopic treatment and acid suppression are now the standard of care.
- Trial name
- NCT03216395
- Testing
- Over-the-scope Clips, Hemo-clipping, thermo-coagulation
- Where
- 8 sites in Australia, China and 1 more
- Volunteers
- 191 people
- Sponsor
- Chinese University of Hong Kong
Achalasia
POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders
POEM has recently described as an alternative treatment for achalasia in humans. In this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus.
- Trial name
- POEM (NCT01512719)
- Testing
- POEM
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Liver Disease
A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices
Compare VBL and cyanoacrylate injection (CI) in the treatment of EV in patients with advanced liver disease regarding eradication, bleeding, mortality, complication and recurrence rates.
- Trial name
- NCT00799851
- Testing
- Variceal band ligation, cyanoacrylate injection
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Federal University of São Paulo
Gastro Esophageal Reflux Disease
Endoscopic Full Thickness Plication (GERD-X) for the Treatment of PPI Dependent GERD:
Gastro-esophageal reflux disease (GERD) is a common gastrointestinal disorder with a significant proportion of patients becoming dependent on proton pump inhibitor (PPI) therapy.
- Trial name
- NCT03322553
- Testing
- GERD-X
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Non-alcoholic Steatohepatitis (NASH)
Endoscopic Bariatric Therapy in NASH Cirrhosis
Non-alcoholic steatohepatitis (NASH) is a growing public health problem that affects more than 5% of the population and can lead to cirrhosis and hepatocellular carcinoma.
- Trial name
- ETHIC (NCT04281303)
- Testing
- Endoscopic vertical gastroplasty
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Zenker Diverticulum, Diverticulum, Esophago-Pharyngeal
Comparison of Zenker's Diverticulum Treatment Using Peroral Endoscopic Myotomy and Flexible Endoscopy Septotomy.
The Zenker's or pharyngo-esophageal diverticulum is an acquired sac-like outpouching of the mucosa and submucosa layers located dorsally at the pharyngoesophageal junction through Killian's dehiscence.
- Conditions
- Zenker Diverticulum, Diverticulum, Esophago-Pharyngeal, Diverticulum, Esophageal, Dysphagia
- Trial name
- ZIPPY (NCT04514042)
- Testing
- Peroral endoscopic myotomy, Flexible endoscopic septotomy
- Where
- Poland
- Volunteers
- 165 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Ectopic Pregnancy
Comparison of Two Different Approaches in the Surgical Treatment of Tubal Ectopic Pregnancy
In this study we aim to compare conventional laparoscopy and natural orifice transluminal endoscopic surgery in the surgical treatment of ectopic pregnancy.
- Trial name
- NCT04315779
- Testing
- Salpingectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ege University
Chronic Pain
Sedation in Endoscopic Retrograde Cholangiopancreatography (ERCP) With or Without Opioids
Addition of fentanyl or remifentanil to the propofol produced sedation for scheduled ERCP will decrease the propofol requirements for predetermined sedation levels (as shown by Bispectral Index Monitor (BIS) monitor), will be…
- Trial name
- NCT01304342
- Testing
- Remifentanil, Fentanyl, Normal saline
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- University of Athens
Urolithiasis
Ureteroscopy With and Without Safety Guidewire
The purpose of this study is to investigate the impact of a safety guidewire (SGW) on the results of ureteroscopy for urolithiasis.
- Trial name
- NCT01117688
- Testing
- Ureteroscopy with and without safety guidewire
- Where
- Norway
- Sponsor
- Helse-Bergen HF
Bladder Cancer
Investigation Into the Integration of Intracavitary Cryoablation and Immunotherapy in Bladder-Preserving Therapy
Professional Translation: This study is a single-center, prospective, non-randomized, parallel-controlled clinical trial initiated and conducted by the Department of Urology at the First Affiliated Hospital of Naval Medical…
- Trial name
- NCT07204132
- Testing
- TURBT combined with cryoablation-assisted postoperative immunotherapy, The conventional surgery treatment group
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Changhai Hospital
Liver Cirrhosis, Esophageal and Gastric Varices
The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding
To compare the efficacy and safety of Carvedilol and endoscopic therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding.
- Trial name
- NCT02695732
- Testing
- Carvedilol, endoscopy
- Where
- China
- Volunteers
- 792 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Neoplasms, Stomach Neoplasms
Early Detection of Esophageal Cancer
Esophageal cancer is a common malignancy with a very poor prognosis. The principal reason for its poor prognosis is that most tumors are asymptomatic and go undetected until they have spread beyond the esophageal wall and are…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Endoscopy, Gastrointestinal, Digestive System Endoscopic Surgical Procedures
- Trial name
- NCT00341523
- Where
- China
- Volunteers
- 6,864 people
- Sponsor
- National Cancer Institute (NCI)
Hydrocephalus in Children
Precision Surgery for Pediatric Hydrocephalus: VPS vs. ETV With ML-Guided Prediction
Study type: Multicenter retrospective cohort study with prospective validation Primary purpose: To determine whether an individualized, imaging-guided treatment algorithm Ventriculoperitoneal shunt (VPS) vs endoscopic third…
- Trial name
- VPS ETV ML (NCT07330206)
- Testing
- MRI-Guided Precision Shunt or ETV Strategy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- West China Hospital
Crohn Disease
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
Crohn's disease (CD) is a condition that causes inflammation (swelling, redness) of the lining and wall of the small intestine, large intestine, or both.
- Trial name
- CAMEO (NCT05781152)
- Testing
- Anti-TNF therapy
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,270 people
- Sponsor
- Connecticut Children's Medical Center
Renal Stone
Perioperative Parameter and Treatment Outcomes of ECIRS in Asia
This is an observational, international, multicenter, cohort study, prospectively collecting clinical data registry on consecutive patients with urinary stone undergoing ECIRS.
- Trial name
- NCT05894668
- Testing
- ECIRS
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Crohn Disease
Efficacy and Safety of Dual-targeted Therapy With Upadacitinib and Ustekinumab Versus Intensified Ustekinumab Therapy in Crohn's Disease
The goal of this clinical trial is to evaluate the efficacy and safety of dual-target therapy (Ustekinumab combined with Upadacitinib) versus intensified Ustekinumab monotherapy in patients with Crohn's disease who have an…
- Trial name
- NCT06520397
- Testing
- Ustekinumab and Upadacitinib, Ustekinumab
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Achalasia
Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia
This is a pilot study for a new endoscopic treatment of achalasia. Up to 25 patients will be recruited for this trial, with the intent to treat 20 patients.
- Trial name
- POEM (NCT02073578)
- Testing
- Peroral Endoscopic Myotomy (POEM)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
GERD, Reflux Esophagitis
A Novel Endoloop Pre-test to Treat Gastroesophageal Reflux
The purpose of this study was to evaluate the safety and efficacy of endoscopic endoloop pre-test for gastroesophageal reflux before anti-reflux surgery or endoscopic treatment.
- Trial name
- NCT05192538
- Testing
- Endoscopic endoloop pre-test treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Obesity, Morbid
Aspiration Therapy for Obese Adolescents
Interventional studies devoted to adolescents are relatively rare in the world. This has several reasons. Treatment and research on obesity are centered on advanced forms of obesity in adults, bearing in mind that social and…
- Trial name
- NCT03598920
- Testing
- AsspireAssist, Nutritional consulting
- Where
- 3 sites in Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Ostrava