Clinical trials: Therapeutic Endoscopy
Achalasia
Evaluation of a Novel Endoscopic Treatment for Achalasia
This study is to evaluate outcomes of a less invasive surgical procedure for the treatment of achalasia.
- Trial name
- POEM (NCT01770249)
- Testing
- Per-oral Endoscopic Esophagomyotomy (POEM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Painful Bladder Syndrome (PBS), Interstitial Cystitis
Submucosal Intravesical Injection of Platelet-rich Plasma in the Treatment of Painful Bladder Syndrome
Interstitial cystitis/painful bladder syndrome (IC/PBS) is characterized by a constellation of bladder symptoms, including urinary frequency, urgency, nocturia, and pelvic pain.
- Trial name
- PRP (NCT06209008)
- Testing
- Intravesical injection of Platlet Rich Plasma (PRP)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cholecystectomy, Gallbladder
EUS-Guided Gallbladder Drainage Versus Conservative Management in Patients Unfit for Surgery After a Biliary Event Without Cholecystitis. DRECON Study
Cholecystectomy is considered the standard definitive treatment after an acute biliary event (biliary colic, acute pancreatitis, cholangitis, or choledocholithiasis).
- Conditions
- Cholecystectomy, Gallbladder, Endoscopic Ultrasound (EUS), Cholelithiasis
- Trial name
- DRECON (NCT07655778)
- Testing
- EUS-guided gallbladder drainage (EUS-GBD), Conservative management (CM)
- Volunteers
- 110 people
- Sponsor
- Hospital Mutua de Terrassa
Adenocarcinoma of the Esophago-gastric Junction
Comparison Study of Brachytherapy and Endoscopic Stenting for Dysphagia in Esophago-Gastric Junction Cancer
The objective of the study is comparison of the efficacy and safety of palliative therapy with single-dose brachytherapy or selfexpanding metal stents (SEMS) in malignant dysphagia resulting from adenocarcinoma of the…
- Trial name
- BRASTEGAC (NCT01786278)
- Testing
- Brachytherapy, Endoscopic stenting
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lublin
Portal Vein Thrombosis, Liver Cirrhosis
TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further…
- Trial name
- NCT02485184
- Testing
- Transjugular intrahepatic portosystemic shunt, Non-selective beta blockers, Endoscopic therapy
- Where
- 8 sites in China
- Volunteers
- 120 people
- Sponsor
- Air Force Military Medical University, China
Zenker Diverticulum
A New Treatment for Zenker's Diverticulum-submucosal Tunneling Endoscopic Septum Division
Zenker's Diverticulum (ZD) is a sac-like outpouching of the lining of the esophageal wall at the upper esophagus. It is a rare disease typically seen in the middle-aged and older adults.
- Trial name
- STESD (NCT03125733)
- Testing
- Submucosal tunneling endoscopic septum division
- Where
- 2 sites in United States, China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Barrett Esophagus, Esophageal Neoplasms
Study of Cryotherapy Treatment of Barrett's Esophagus and Early Esophageal Cancer
The purpose of this study is to confirm the effectiveness and safety of a new medical device which sprays liquid nitrogen through an upper endoscope (cryotherapy) to treat Barrett's esophagus with high-grade dysplasia and early…
- Conditions
- Barrett Esophagus, Esophageal Neoplasms, Deglutition Disorders, GERD
- Trial name
- NCT00321958
- Testing
- CSA System (CryoSpray AblationTM System), CryoSpray Ablation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Maryland, Baltimore
Esophagogastric Varices, Portal Hypertension
Treatment Outcomes for Portal Hypertension Esophageal and Gastric Varices
This study is a single-center, prospective cohort study based on real-world data. Patients with portal hypertension and esophagogastric varices were enrolled and divided into an endoscopic treatment group and a non-endoscopic…
- Trial name
- NCT07358663
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- Shanghai Zhongshan Hospital
Inoperable, Painful Pancreatic Cancer
Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis
Pancreatic cancer presents with pain in the majority of cases. Destruction of the celiac ganglia by ultrasound guided injection of sclerosing agents such as alcohol is sometimes used for pain that no longer responds to treatment…
- Trial name
- NCT00974948
- Testing
- EUS-guided celiac plexus neurolysis
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas
Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer
This phase I trial studies the side effects and best dose of ultrasound-guided photodynamic therapy with porfimer sodium when given together with gemcitabine hydrochloride in treating patients with locally advanced pancreatic…
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Stage III Pancreatic Cancer
- Trial name
- NCT01770132
- Testing
- porfimer sodium, endoscopic ultrasonography, photodynamic therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- John DeWitt
Plantar Fasciitis
Plantar Fasciitis, Operation or Conservative Treatment
The purpose of this study is to compare in a randomized controlled trial the effect of endoscopic operation with the standard conservative treatmentprotocol with training supplemented with 1-3 injections of glucocorticoids in…
- Trial name
- NCT02448316
- Testing
- endoscopic surgery, methylprednisolon, lidokaine
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Cluster Headache
Botox Injection in Treatment of Cluster Headache
Cluster headache is an intense and powerful, one-sided headache accompanied by involuntary symptoms such as red eye, droopy eyelids, flow of tears, small pupils and one-sided facial sweating.
- Trial name
- NCT02019017
- Testing
- Botulinum Toxin Type A 25 IU, Botulinum Toxin Type A 50 IU
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
GastroIntestinal Bleeding
Effectiveness and Safety of Nexpowder as an Endoscopic Hemostatic Treatment
In patients who show signs of bleeding and bleeding after polypectomy such as EMR and ESD for polyps with a diameter of 2 cm or more in the lower gastrointestinal tract, the effectiveness and safety of Nexpowder as an endoscopic…
- Trial name
- NCT05884931
- Testing
- Nexpowder, Conventional Treatment
- Where
- 3 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Next Biomedical Co., Ltd.
Recurrent Nasopharyngeal Carcinoma
Adjuvant vs Surgery Only in Early-stage Recurrent NPC
Adjuvant Therapy Versus Endoscopic Surgery Alone in Early-stage Recurrent Nasopharyngeal Carcinoma: A Multicenter Randomized Controlled Trial
- Trial name
- NCT06228079
- Testing
- Immunotherapy,Toripalimab Injection, Chemotherapy,Gemcitabine based regimen
- Where
- 7 sites in China
- Volunteers
- 176 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Lumbar Disc Herniation
Full-Endoscopic vs Open Discectomy for the Treatment of Symptomatic Lumbar Herniated Disc
The purpose of this study is to compare the clinical and radiographic outcomes of full endoscopic lumbar discectomy versus open lumbar decompression for the treatment of lumbar herniated discs in which the patient's leg pain is…
- Trial name
- NCT02441959
- Testing
- Lumbar discectomy Open, Lumbar discectomy Endoscopic
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Yale University
Hypoxemia
Anesthesia Endoscope Mask is Applied to Sedation Upper Gastrointestinal Endoscopic Diagnosis and Treatment
To investigate the efficacy and safety of new-type mask compared with nasal tube oxygen delivery in patients undergoing sedation of upper gastrointestinal endoscopy
- Trial name
- NCT06085859
- Testing
- Routine nasal catheter group, Mask group
- Where
- 5 sites in China
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Cholangiocarcinoma
Comparison of Endoscopic Radiofrequency Ablation Versus Photodynamic Therapy for Inoperable Cholangiocarcinoma
The purpose of this study is to compare endoscopic radiofrequency ablation with photodynamic therapy for inoperable cholangiocarcinoma
- Trial name
- NCT01739465
- Testing
- Self expanding metallic stent (SEMS), Endoscopic radiofrequency ablation (ERFA), Photodynamic therapy (PDT)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Guangzhou Medical University
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Obesity
Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass
It is estimated that up to 20% of patients who have Roux-en-Y Gastric Bypass (RYGB) surgery will not meet their weight loss goal, or may even regain some of the weight they initially lost.
- Trial name
- NCT00394212
- Testing
- Transoral Suturing
- Where
- 10 sites in United States
- Volunteers
- 77 people
- Sponsor
- C. R. Bard
Patient Satisfaction
Patient Satisfaction and Safety With Propofol Based Sedation With or Without Fentanyl for Gastrointestinal Endoscopy
Patient satisfaction and safety with propofol based sedation with or without fentanyl for gastrointestinal endoscopy
- Trial name
- NCT03803449
- Testing
- 50-200mg propofol, 50ug fentanyl, 1 mg midazolam
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shandong University