Clinical trials: Therapeutic Endoscopy
Gastro Esophageal Reflux Disease
Endoscopic Full Thickness Plication (GERD-X) for the Treatment of PPI Dependent GERD:
Gastro-esophageal reflux disease (GERD) is a common gastrointestinal disorder with a significant proportion of patients becoming dependent on proton pump inhibitor (PPI) therapy.
- Trial name
- NCT03322553
- Testing
- GERD-X
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Asian Institute of Gastroenterology, India
Blind Loop Syndrome Postoperative, Candy Cane Syndrome
Evaluation of the Performance of MAgnetic Gastrointestinal Universal Septotome for Treatment of Candy Cane Syndrome
Candy cane syndrome (CCS) is an adverse event (AE) from gastrectomy or gastric bypass and end-to-side anastomosis to a jejunal loop.
- Trial name
- MAGUS-CCS (NCT05938439)
- Testing
- MAGUS placement
- Where
- Belgium
- Volunteers
- 51 people
- Sponsor
- Erasme University Hospital
Rhinocerebral Mucormycosis
Endoscopic Surgical Treatment of Rhino-Sinusal Mucormycosis
Radical endoscopic transnasal surgery associated with medical treatment with liposomal amphotericine B may increase the local control of Rhino-Sinusal Mucormycosis and the survival rate.
- Trial name
- MICCA (NCT02226705)
- Testing
- Multiple transnasal endoscopic surgeries
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stenosis, Crohn's Disease
Comparative Prospective Multicenter Randomized Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
This study will be a multicentre randomized controlled trial to assess the efficacy between balloon dilatation and self-expanding metallic stent placement for endoscopic treatment of stenosis in Crohn´s Disease.
- Conditions
- Stenosis, Crohn's Disease, Chronic Inflammation
- Trial name
- PROTDILAT (NCT02395354)
- Testing
- Placing a self-expanding metallic stent, A balloon dilatation
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Esophageal Neoplasms, Stomach Neoplasms
Early Detection of Esophageal Cancer
Esophageal cancer is a common malignancy with a very poor prognosis. The principal reason for its poor prognosis is that most tumors are asymptomatic and go undetected until they have spread beyond the esophageal wall and are…
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Endoscopy, Gastrointestinal, Digestive System Endoscopic Surgical Procedures
- Trial name
- NCT00341523
- Where
- China
- Volunteers
- 6,864 people
- Sponsor
- National Cancer Institute (NCI)
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Endoscopic Pilonidal Sinus
Intervetional Lay Open and Curettage Versus Endoscopic (E.P.Si.T) Method in the Treatment of Sacrococcygeal Pilonidal Sinus Disease
Aim of the work To compare lay open technique versus Endoscopic pilonidal sinus treatment as regards recurrence rate, operative data, postoperative pain, intra and postoperative complications, healing time and return to daily…
- Trial name
- NCT04418310
- Testing
- Lay open and curettage, Endoscopic (E.P.Si.T) method
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Type 2 Diabetes Mellitus, Type2diabetes
Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes
This study is designed to evaluate the safety and effectiveness of endoscopic intestinal re-cellularization therapy in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering medications.
- Conditions
- Type 2 Diabetes Mellitus, Type2diabetes, Diabetes Mellitus, Type 2, Diabetes
- Trial name
- NCT06267391
- Testing
- Endogenex Treatment
- Where
- 44 sites in United States, Australia
- Volunteers
- 350 people
- Sponsor
- Endogenex, Inc.
Adenocarcinoma of the Esophago-gastric Junction
Comparison Study of Brachytherapy and Endoscopic Stenting for Dysphagia in Esophago-Gastric Junction Cancer
The objective of the study is comparison of the efficacy and safety of palliative therapy with single-dose brachytherapy or selfexpanding metal stents (SEMS) in malignant dysphagia resulting from adenocarcinoma of the…
- Trial name
- BRASTEGAC (NCT01786278)
- Testing
- Brachytherapy, Endoscopic stenting
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lublin
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism
In this study, the investigators will perform endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) treatment of left-sided adrenal tumours in patients with primary aldosteronism (PA) and in patients with mild autonomous…
- Conditions
- Primary Aldosteronism, Aldosterone-Producing Adenoma, Hypercortisolism
- Trial name
- NCT05368090
- Testing
- EUS-RFA of left adrenal tumour in PA with AVS-verified left lateralisation, EUS-RFA of left adrenal tumour in PA, "debulking group", EUS-RFA of left adrenal tumour in MACS with AVS-verified left lateralisation
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Chronic Rhinosinusitis With Nasal Polyps
Dupilumab for Prevention of Recurrence of CRSwNP After ESS
The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus…
- Trial name
- NCT04596189
- Testing
- Dupilumab 300 MG in 2 ML Prefilled Syringe, Mometasone Furoate nasal spray
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Peptic Ulcer
Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding
To assess the efficacy and safety of the early administration of somatostatin in infusion during 72 hours plus 2 boluses, compared to placebo in the control of acute severe UGIB with suspicion of PUB.
- Trial name
- NCT00152399
- Testing
- Somatostatin UCB (drug)
- Where
- 22 sites in Belgium, France and 4 more
- Volunteers
- 370 people
- Sponsor
- UCB Pharma
Pancreatic Walled-off Necrosis
The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)
In this multicenter, randomized controlled trial, patients with pancreatic walled-off necrosis (WON) based on inclusion and exclusion criteria will be randomly assigned in a 1:1 ratio to either receive intravenous infusion or…
- Trial name
- NCT07488299
- Testing
- Proton Pump Inhibitors
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qilu Hospital of Shandong University
Gastroparesis
G-POEM vs PEG-J in Gastroparesis Patients
Study design: A randomized non-blinded controlled clinical trial with two study arms (G-POEM and PEG-J). Treatment success is measured using the GCSI at baseline before intervention and six months after intervention with a…
- Trial name
- NCT06372132
- Testing
- G-POEM
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Liver Cirrhosis, Gastroesophageal Varices
Feasibility and Safety Evaluation of Endoscopic Treatment of Esophagogastric Varices in Cirrhosis on the Day-care Unit
The goal of this observational study is to learn about the feasibility and safety evaluation of endoscopic treatment of esophagogastric varices in cirrhosis on the day-care ward.
- Trial name
- NCT07129447
- Volunteers
- 330 people
- Sponsor
- Qilu Hospital of Shandong University
Atrial Fibrillation
HeartLight X3 Endoscopic Ablation System With Excalibur Balloon for Treatment of Symptomatic Persistent AF
The objective of the study is to demonstrate the improved ablation and procedure times of the HeartLight X3 compared to the original HeartLight catheter in the treatment of persistent atrial fibrillation.
- Trial name
- NCT03988244
- Testing
- HeartLight X3
- Where
- Czechia
- Volunteers
- 11 people
- Sponsor
- CardioFocus
Esophagitis, Reflux
Efficiency Study of S-Tenatoprazole-Na to Treat Erosive or Ulcerative Esophagitis
STU-Na belongs to the proton pump inhibitors (PPI), a group of drugs that reduce gastric acidity. PPI are used to treat acid related diseases like erosive or ulcerative esophagitis.
- Trial name
- NCT00282555
- Testing
- S-Tenatoprazole-Na (STU-Na)
- Where
- 17 sites in Canada
- Volunteers
- 450 people
- Sponsor
- STEBA France
Severe Ulcerative Colitis
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
Up to one third of patients with Ulcerative Colitis (UC) will require hospitalisation for severe disease (ASUC - Acute Severe Ulcerative Colitis), often within the first 12 months of diagnosis.
- Trial name
- ELEVATE-ASUC (NCT03907631)
- Testing
- Standard of care
- Where
- United Kingdom
- Volunteers
- 189 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Antro-pyloric and/or Duodenal Benign or Malignant Obstructions
Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance.
Achieving gastro-jejunal or duodenal anastomosis (GJA ) by exclusive endoscopically is a real goal for many years in the development and research of the transluminal endoscopic surgery (N.O.T.E.S).
- Trial name
- NCT02562157
- Testing
- HYALURONIQUE ACIDE
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Colorectal Cancer
Risk Factors for Residual Neoplasia After Endoscopic Mucosal Resection
Laterally Spreading Tumors (LST) are important precursosrs of invasive colorectal cancer. Endoscopic treatment has replaced surgery in most of the cases.
- Trial name
- NCT01478919
- Where
- Czechia
- Volunteers
- 127 people
- Sponsor
- Vitkovice Hospital