Clinical trials: Therapeutic Endoscopy
Barrett Esophagus, Esophageal Adenocarcinoma
Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus
This study compares patients' acceptability and safety of two established endoscopic methods for treating dysplastic Barrett's esophagus: radiofrequency ablation versus hybrid argon plasma coagulation.
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Reflux Disease
- Trial name
- RATE (NCT05051475)
- Testing
- Endoscopic radiofrequency ablation, Endoscopic hybrid argon plasma coagulation
- Where
- Poland
- Volunteers
- 62 people
- Sponsor
- Centre of Postgraduate Medical Education
Compensated Cirrhosis, Gastroesophageal Varices Bleeding
Detachable String Magnetically Controlled Capsule Endoscopy for Detecting High-risk Varices in Compensated Cirrhosis
Gastroesophageal varices is a serious complication of compensated advanced chronic liver disease (cACLD). Primary prophylaxis to reduce the risk of variceal haemorrhage is recommended if high-risk varices (HRV) are detected.
- Trial name
- NCT03749954
- Testing
- Detachable string magnetically controlled capsule endoscopy
- Where
- 13 sites in China, United Kingdom
- Volunteers
- 105 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gastric Varices
Acute Gastric Variceal Bleeding: Endoscopic Treatment Versus BRTO
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the management of acute gastric bleeding.
- Trial name
- NCT02468167
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Gastric GIST
Endoscopic Full Thickness Resection for Gastric GIST
This is a clinical trial to evaluate the efficacy and safety of endoscopic full thickness resection for treatment of gastric GIST
- Trial name
- EFTR (NCT04198337)
- Testing
- Endoscopic Full Thickness Resection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Gastroesophageal Reflux Disease
Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
The aims of this study are to create a prospective data base to evaluate the long term outcomes of medical and surgical treatment of gastroesophageal reflux disease (GERD); to measure standard outcomes as well as patient derived…
- Trial name
- NCT00260572
- Testing
- Questionnaires to evaluate QOL, Questionnaires to evaluate heartburn and quality of life, Questionnaire to evaluate satisfaction with treatment
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- University of Pittsburgh
Atrial Fibrillation (Paroxysmal)
Pulmonary Vein Isolation With the Single Shot Endoscopic Ultra-Compliant PFA Balloon for the Treatment of AF
This is a prospective, single-arm First-in-Human study to demonstrate the safety and effectiveness of the CardioFocus OptiShot Pulsed Field Ablation System for catheter ablation of atrial fibrillation (AF).
- Trial name
- VISION AF (NCT06828939)
- Testing
- pulsed field ablation
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- CardioFocus
Lumbar Spondylolisthesis, Unilateral Biportal Endoscopy
A RCT of UBE vs. MIS-TLIF in Lumbar Spondylolisthesis
Unilateral biportal endoscopy (UBE) is a new spinal minimally invasive technique improved for the treatment of lumbar spondylolisthesis (LSP).
- Conditions
- Lumbar Spondylolisthesis, Unilateral Biportal Endoscopy, Minimally Invasive Technique, Surgical Treatment
- Trial name
- NCT05480267
- Testing
- surgical treatment for lumbar spondylolisthesis
- Volunteers
- 340 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric Outlet Obstruction
Enteral Anastomosis for the Treatment of Gastric Outlet Obstruction: A Randomized Controlled Study Comparing Endoscopic Versus Surgical Gastrojejunostomy
Gastric outlet obstruction (GOO) occurs commonly in malignancies involving the periampullary region (cancers originating in the head of the pancreas, duodenum, bile duct, or ampulla) or the distal stomach.
- Trial name
- EAT-GO (NCT05561907)
- Testing
- Surgical gastrojejunostomy (SGJ), Endoscopic gastrojejunostomy (EGJ)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Northwell Health
Hemorrhoid, Hemorrhoids
Endoscopic Injection Sclerotherapy Versus Endoscopic Band Ligation for Grade I-III Internal Hemorrhoids
This study is a prospective, multicentre, and randomized-controlled clinical study.The researchers wanted to explore the optimal treatment regimen for soft hemorrhoid within I-Ⅲ degrees by evaluating and comparing the…
- Conditions
- Hemorrhoid, Hemorrhoids, Hemorrhoids Internal, Hemorrhoid Prolapse
- Trial name
- NCT05089500
- Testing
- Endoscopic injection sclerotherapy, Endoscopic Band Ligation
- Where
- 2 sites in China
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Gastrointestinal Haemorrhage
Purastat® vs Standard Therapy for Haemostasis During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is an endoscopic resection technique used to treat superficial neoplasia in the gastrointestinal tract.
- Trial name
- NCT02833558
- Testing
- PuraStat®, Electrocautery
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Walled-off Necrosis
A Comparison Between Lumen-apposing Metal Stent and Double-pigtail Plastic Stents for Treatment of Walled-off Necrosis
Walled-off necrosis (WON) is defined as an encapsulated collection of solid and liquid necrotic material that is usually formed 4 weeks after an episode of acute necrotizing pancreatitis.
- Trial name
- NCT04876235
- Testing
- endoscopic ultrasound, lumen-apposing metal stent, double-pigtail plastic stents
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First People's Hospital of Hangzhou
Primary Esophageal Motility Disorders Including Achalasia and Hypertensive LES
Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders
rimary spastic esophageal motility disorders, though uncommon, induce significant symptoms to patients including dysphagia, spastic chest pain, regurgitation as well as heartburn.
- Trial name
- POEM (NCT01524458)
- Testing
- Per-Oral Endoscopic Myotomy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Dyspepsia
Use of Maytenus Ilicifolia in the Treatment of Dyspepsia
This study aims to evaluate the therapeutic effect of the infusion of Maytenus ilicifolia Mart. ex Reiss leaves, used for 8 weeks, on patients with dyspepsia.
- Trial name
- NCT01408849
- Testing
- Maytenus ilicifolia leaves infusion, Omeprazole
- Where
- Brazil
- Volunteers
- 4 people
- Sponsor
- Casa Espirita Terra de Ismael
Renal Stone
Perioperative Parameter and Treatment Outcomes of ECIRS in Asia
This is an observational, international, multicenter, cohort study, prospectively collecting clinical data registry on consecutive patients with urinary stone undergoing ECIRS.
- Trial name
- NCT05894668
- Testing
- ECIRS
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Chronic Rhinosinusitis With Nasal Polyps
Dupilumab for Prevention of Recurrence of CRSwNP After ESS
The investigators believe that administering Dupilumab during the pre- and peri-operative period of surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) will safely downregulate Type 2 inflammation of the healing sinus…
- Trial name
- NCT04596189
- Testing
- Dupilumab 300 MG in 2 ML Prefilled Syringe, Mometasone Furoate nasal spray
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Zenker Diverticulum
Endoscopic Treatment of Zenker's Diverticulum (ZENKTUN)
Prospective comparative observational study in numerous reference centers in France, comparing Tunnelization (Z-POEM) versus Non-Tunnelization Techniques according to the usual practices.
- Trial name
- NCT06594718
- Testing
- Endoscopic diverticulotomy with Z-POEM, Endoscopic diverticulotomy using a non-tunnelization technique
- Volunteers
- 128 people
- Sponsor
- Société Française d'Endoscopie Digestive
Gastroesophageal Reflux Disease (GERD)
Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
The study objective is to evaluate the relative merits, safety and effectiveness of Transoral Incisionless Fundoplication (TIF) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs).
- Trial name
- TvP (NCT00857597)
- Testing
- Transoral Incisionless Fundoplication, Proton Pump Inhibitors; active control
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Superficial Esophageal Cancers
Status of Superficial Esophageal Cancers Treated by Endoscopy "OESOFARE"
In 2013, esophageal cancer was the 9th cause of cancer in the world and the 6th in terms of cancer mortality. The prognosis of this cancer varies according to geographical areas, but in Europe and the USA, the 5-year survival…
- Trial name
- OESOFARE (NCT03674801)
- Where
- France
- Volunteers
- 151 people
- Sponsor
- Nantes University Hospital
Chronic Pancreatitis
Predictive Biomarker for Endoscopic Therapy in Chronic Pancreatitis
This is an observational prospective study to develop predictive biomarkers for pain response in participants with chronic pancreatitis scheduled for endoscopic therapy.
- Trial name
- NCT06267365
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health