Clinical trials: Therapeutic Exercise
Low Back Pain
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
Introduction: The McKenzie method as well as spinal manipulation is commonly used for the treatment of low back pain throughout the western world.
- Trial name
- NCT00939107
- Testing
- spinal manipulation, McKenzie exercises
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Type 1 Diabetes Mellitus, MDI
Evaluation of Physician-based Decision Support
The goal of this study is to assess the impact of physician-driven insulin setting changes in type 1 patients using multiple daily injection insulin therapy with exercise.
- Conditions
- Type 1 Diabetes Mellitus, MDI, CGM, Exercise
- Trial name
- NCT03443713
- Testing
- Dexcom G6 CGM
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Photobiomodulation Therapy, Photomedicine
Photomedicine Project 14: PBMT for Performance Enhancement in SOF
Special Operations Forces (SOF) train continually to maintain peak performance. Thus, they are nearly always in a state of recovery, and in need of noninvasive therapies to address the taxing workload.
- Conditions
- Photobiomodulation Therapy, Photomedicine, Low-Level Laser Therapy, Performance Enhancement
- Trial name
- SOF (NCT06380179)
- Testing
- THOR3 training + Photobiomodulation Therapy (PBMT)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Musculoskeletal Injury Rehabilitation Research for Operational Readiness
Diabetes, Diabetes Mellitus, Type 2
A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes
This trial is conducted in Asia. The aim of the trial is to investigate safety and efficacy of semaglutide once weekly in monotherapy or in combination with one OAD (oral anti-diabetic drug) in Japanese subjects with type 2…
- Trial name
- SUSTAIN™ (NCT02207374)
- Testing
- semaglutide, DPP-4 inhibitor
- Where
- 43 sites in Japan
- Volunteers
- 601 people
- Sponsor
- Novo Nordisk A/S
Angina
Effect of Febuxostat Compared to Placebo on Exercise Tolerance in Participants With Chronic Stable Angina
The purpose of this study is to evaluate the effect of febuxostat, once daily (QD), compared to placebo as an add on to stable anti-anginal therapy, on the total exercise time of participants with Chronic Stable Angina.
- Trial name
- NCT01549977
- Testing
- Febuxostat
- Where
- 21 sites in United States
- Volunteers
- 1 people
- Sponsor
- Takeda
Hypertension
Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)
More than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP) putting them at high risk for cardiovascular (CV) disease and death.
- Trial name
- NCT04112043
- Testing
- Walking Exercise, Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- University of Florida
Sickle Cell Disease, Sickle Cell Anemia
Actigraphy Improvement With Voxelotor (ActIVe) Study
This is a study to evaluate the effect of voxelotor on daily physical activity and sleep quality, as measured by a wrist-worn device in participants with sickle cell disease (SCD) and chronic moderate anemia.
- Trial name
- ActIVe (NCT04400487)
- Testing
- Voxelotor
- Where
- 10 sites in United States
- Volunteers
- 25 people
- Sponsor
- Pfizer
Severe Hereditary Factor VIII Deficiency Disease Without Inhibitor, Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor
An Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, in Participants With Haemophilia A Without Inhibitors Receiving Standard of Care Treatment
This multicenter, non-interventional, prospective study will collect information about activity status, bleeds, health-related quality of life (HRQoL), health status, and safety in participants with moderate or severe haemophilia…
- Conditions
- Severe Hereditary Factor VIII Deficiency Disease Without Inhibitor, Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor, Haemophilia A
- Trial name
- POWER (NCT04165135)
- Testing
- Standard of Care for Haemophilia A
- Where
- 17 sites in Italy
- Volunteers
- 103 people
- Sponsor
- Hoffmann-La Roche
Breast Cancer
Study to Evaluate Patient Reported Outcome (PRO) and Physical Activity in Japanese Patients With HR+/HER2- Advanced Breast Cancer Treated With Palbociclib Plus Endocrine Therapy or Endocrine Monotherapy
The study is a prospective, multicenter, observational study to evaluate PRO and physical activity using smartphone-based application and wearable device in Japanese patients with HR+/HER2- advanced breast cancer (ABC).
- Trial name
- JBCRG-26 (NCT04736576)
- Testing
- Wearable device
- Where
- 20 sites in Japan
- Volunteers
- 99 people
- Sponsor
- Pfizer
Alveolitis, Fibrosing, Fibrosis, Pulmonary
Sildenafil Study to Treat Idiopathic Pulmonary Fibrosis
Medicines that decrease blood pressure in the lungs may help idiopathic pulmonary fibrosis (IPF) patients function better. This study will test whether sildenafil improves the ability to exercise in patients with pulmonary…
- Conditions
- Alveolitis, Fibrosing, Fibrosis, Pulmonary, Hypertension, Pulmonary
- Trial name
- NCT00359736
- Testing
- sildenafil
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes
Safety and Efficacy Study of Subjects That Are Taking Saxagliptin Added Onto Metformin XR Compared to Subjects Taking Metformin XR Alone
This protocol will compare 24 hour glucose control for subject taking saxagliptin and metformin extended release (XR) versus metformin XR alone
- Trial name
- NCT00683657
- Testing
- Saxagliptin
- Where
- 27 sites in United States, Argentina and 6 more
- Volunteers
- 93 people
- Sponsor
- AstraZeneca
Pulmonary Arterial Hypertension
Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test
Evaluate for accuracy and reproducibility of data collected via the participant-operated Walk.Talk.Track. (WTT) app combined with Apple Watch during in-clinic, technician proctored 6MWT's.
- Trial name
- DynAMITE (NCT03893500)
- Testing
- Home-based 6 minute walk test
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Stanford University
Pulmonary Disease, Chronic Obstructive
Effect of Treatment BI 1744 CL (5 and 10 mcg) Versus Placebo on Exercise Endurance Time During Constant Work Rate Cycle Ergometry II
To compare the effects of BI 1744 CL versus placebo on exercise tolerance after 6 weeks of treatment in patients with Chronic Obstructive Pulmonary Disease.
- Trial name
- NCT01040793
- Testing
- Olodaterol (BI 1744), Olodaterol (BI1744)
- Where
- 19 sites in Austria, Belgium and 3 more
- Volunteers
- 157 people
- Sponsor
- Boehringer Ingelheim
Heart Failure
The Effects of DVD Education on Physical Activity and Self Management of Heart Failure
The purpose of this research is to determine if there is a greater behaviour change in self management of heart failure following reinforced multimedia education focusing on physical activity as compared to standard care.
- Trial name
- NCT01622010
- Testing
- Allied Health Education Class Option, Physiotherapy treatment intervention on referral, Keeping the Beat with Physiotherapy: Heart Failure edition
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Hand Osteoarthritis, Wrist Osteoarthritis
Effects of 12-week Digital Treatment in Patients With Hand OA on Pain and Function
The purpose of this study is to evaluate the effect of a 12 week digital treatment program for patients with hand osteoarthritis.
- Conditions
- Hand Osteoarthritis, Wrist Osteoarthritis, Thumb Osteoarthritis, Finger Osteoarthritis
- Trial name
- NCT05499559
- Testing
- Joint Academy digital treatment
- Where
- Sweden
- Volunteers
- 846 people
- Sponsor
- Joint Academy
Knee Osteoarthritis
Tai Chi and Physical Therapy for Knee Osteoarthritis
We will conduct a large randomized controlled trial comparing the effectiveness and cost-effectiveness of Tai Chi mind-body exercise and standard-of-care Physical Therapy for Knee Osteoarthritis.
- Trial name
- TCPT (NCT01258985)
- Testing
- Tai Chi, Physical Therapy
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Tufts Medical Center
Type 2 Diabetes Mellitus
Double-blind Sitagliptin Add-on Study in Japanese Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Ipragliflozin (MK-0431J-842)
This is a study to assess the safety and efficacy of the addition of sitagliptin in Japanese participants with Type 2 diabetes mellitus (T2DM) who have inadequate glycemic control on ipragliflozin, diet, and exercise therapy.
- Trial name
- NCT02577016
- Testing
- Sitagliptin, Ipragliflozin
- Volunteers
- 141 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Cancer, Peripheral Neuropathy, Secondary to Drugs or Chemicals
Chemotherapy Induced Peripheral Neuropathy. Could Physical Therapy Help Treat Symptoms?
The cause of Chemotherapy-Induced Peripheral Neuropathy (CIPN) is still unknown. An estimated 55-60% of patients will experience lasting symptoms affecting function for years post-treatment.
- Trial name
- NCT02239601
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- CancerCare Manitoba
Type 2 Diabetes Mellitus
Metformin Add-on Regimen Comparison Study in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431A-136)
This study will evaluate the effect of the addition of metformin once daily (q.d.) or twice daily (b.i.d.) to sitagliptin monotherapy in Japanese participants with Type 2 diabetes mellitus (T2DM) who have inadequate glycemic…
- Trial name
- NCT01545388
- Testing
- Sitagliptin, Metformin
- Volunteers
- 337 people
- Sponsor
- Merck Sharp & Dohme LLC
Anxiety Disorder, Cognitive/Functional Effects
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical…
- Conditions
- Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression
- Trial name
- CHALLENGE (NCT00819208)
- Testing
- exercise intervention, counseling intervention, educational intervention
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 889 people
- Sponsor
- Canadian Cancer Trials Group