Clinical trials: Therapy, Directly Observed
Hepatitis C, Medication Adherence
Patient-Centered Models of HCV Care for People Who Inject Drugs
People who inject drugs (PWID) have higher rates of hepatitis C virus (HCV) than do other groups. Effective, safe new treatments called direct-acting antiviral agents (DAAs) have been developed recently.
- Trial name
- HERO (NCT02824640)
- Testing
- Patient Navigation, modified Directly Observed Therapy
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- Prisma Health-Upstate
Dementia, Alzheimer's Disease and Related Dementias
HomeCare Medication Management for People With Dementia
This study will evaluate whether the HomeCare medication management system can improve medication adherence and related outcomes for adults age 65 and older living with dementia, Alzheimer's disease, or related dementias.
- Trial name
- NCT07872072
- Testing
- HomeCare
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- HiDO Technologies
Depression, Hemodialysis-Induced Symptom
Identifying and Treating Depression in Hemodialysis Patients
Depression is present in about 20-30% of hemodialysis patients and is associated with morbidity and mortality. However, depression is inadequately diagnosed and treated among dialysis patients.
- Trial name
- NCT03390933
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MetroHealth Medical Center
Medication Adherence, Liver Transplant
A Pilot Study of mDOT for Immunosuppressant Adherence in Adult Liver Transplant Recipients
The investigators are interested in whether or not the use of a mobile health (mHealth) application increases the rate of immunosuppressant medication adherence among adult liver transplant recipients.
- Trial name
- NCT03515330
- Testing
- mHealth Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Sickle Cell Anaemia
Mobile-Directly Observed Therapy on Adherence to Hydroxyurea
To examine the effect of mobile-directly observed therapy (mDOT) on adherence to HU (mDOT-HuA) adults with SCA at Muhimbili National Hospital (MNH) in Tanzania.
- Trial name
- mDOT (NCT02844673)
- Testing
- Hydroxyurea, Mobile Directly Observed Therapy
- Where
- Tanzania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Muhimbili University of Health and Allied Sciences
HIV/AIDS, Substance Abuse
Directly Observed Antiretroviral Therapy Among Active Drug Users
The goal of this randomized, controlled trial is to compare the effectiveness of a community-based program of providing supervised antiretroviral therapy to HIV-positive drug users, compared to having the patients take the…
- Trial name
- NCT00367172
- Testing
- Directly Administered Antiretroviral Therapy
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Yale University
NIDDM
APAD2: Effects of Rehabilitation Programme in Adapted Physical Activity (APA) Among Type 2 Diabetics
The principal objective is to assess and analyze the effects of a six month programme in Adapted Physical Activity (APA) on physical activity, compliance, and insulin resistance among type 2 diabetics.
- Trial name
- NCT00234273
- Testing
- Rehabilitation programme in Adapted Physical Activity (APA), Therapeutic education primarily focused on dietary
- Where
- 4 sites in France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Directly Observed Therapy, HIV Infections
Directly Observed Therapy in High Risk Populations in Newark, NJ
30 patients with poor antiretroviral therapy compliance will be identified from our pool of patients at Saint Michael's Medical Center and be given Directly observed therapy.
- Trial name
- NCT00285883
- Testing
- Invirase, Norvir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Michael's Medical Center
HIV Infections, Depression
Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy
This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression.
- Trial name
- NCT00338767
- Testing
- Directly Observed Therapy (DOT), Fluoxetine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
Anti-HIV drug therapy works best when the drugs are taken exactly as prescribed by a doctor. Because anti-HIV therapy often involves multiple drugs, some people have difficulty taking them all correctly.
- Trial name
- NCT00036452
- Testing
- lopinavir/ritonavir, emtricitabine, stavudine
- Where
- 29 sites in United States, Puerto Rico and 1 more
- Volunteers
- 402 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetic Foot Ulcer, Therapy, Directly Observed
Nocardia Cell Wall Skeleton for the Treatment of Diabetic Foot Ulcer Wounds
This study was to investigate the efficacy and safety of Nocardia rubra Cell Wall Skeleton (NCWS) in the treatment of diabetic foot ulcer wounds. The study was a prospective, randomized, controlled, multicentre study .
- Trial name
- NCT05368142
- Testing
- Nocardia rubra Cell Wall Skeleton, Silver ions dressing
- Volunteers
- 116 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Electrode Site Reaction, Therapy, Directly Observed
Improvement of Motor Imaginative Ability Through Functional Electrical Stimulation
This is a experimental, randomised, parallel-group, clinical study. A sample of university students will be divided into 4 groups, where one of them will act as a control group (no intervention), and the other three will undergo…
- Trial name
- NCT06109025
- Testing
- FESIA GRASP, VIRTUAL REHAB, GLOBUS ELITE
- Where
- Spain
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Hepatitis C, Chronic
Directly Observed Therapy for HCV in Chennai, India
The primary objective of this pilot trial is to evaluate the feasibility of 12 weeks vs. 24 weeks of field-based directly observed therapy (DOT) for HCV therapy in a resource-limited setting.
- Trial name
- C-DOT (NCT02541409)
- Testing
- Sofosbuvir, Pegylated Interferon alfa-2a, Ribavirin
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hepatitis C, Medication Adherence
Intensive Models of HCV Care for Injection Drug Users
Injection drug users (IDUs) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). HCV treatment leading to sustained viral response (SVR) is associated with increased survival.
- Trial name
- NCT01857245
- Testing
- Intensive Models (mDOT and CGT) of HCV Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Tuberculosis, Pulmonary
Cost-effectiveness of Two Forms of DOTS in a Demonstration Area of the DOTS Strategy in Colombia
Tuberculosis ( TB ) remains a major global public health problems and actions to ensure the diagnosis and complete treatment of all cases is the priority for the control of this disease.
- Trial name
- DOTS (NCT01945905)
- Testing
- Intramural, Extramural
- Where
- Colombia
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Fundación FES
Parkinson Disease, Gait Analysis
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients
Consistent evidence suggests that mitochondrial dysfunction plays a crucial role in Parkinson¿s disease pathogenesis. Inhibition of complex I of the mitochondrial electron transport chain is sufficient to reproduce biochemical…
- Conditions
- Parkinson Disease, Gait Analysis, Therapy, Directly Observed, Metabolic Disease
- Trial name
- NCT05855577
- Testing
- Terazosin
- Volunteers
- 50 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Stroke
Using Artificial Intelligence to Measure and Optimize Adherence in Patients on Anticoagulation Therapy.
AiCure uses artificial intelligence and visual recognition technology to confirm medication ingestion. The software is available as an app and downloaded onto a smart phone.
- Trial name
- NCT02599259
- Testing
- Monitored (M+)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- AiCure
Tuberculosis
Wirelessly Observed Therapy in Comparison to Directly Observed Therapy for the Treatment of Tuberculosis
This study uses an ingestion sensor and a wearable sensor (worn as a patch on the skin), which are new Proteus Digital Health (PDH) technologies approved by the FDA, to collect information about patients taking their TB…
- Trial name
- NCT01960257
- Testing
- Digital Health Feedback System, SOC DOT
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of California, San Diego
Latent Tuberculosis Infection
Study 33: Adherence to Latent Tuberculosis Infection Treatment 3HP SAT Versus 3HP DOT
The study is an open label, multicenter, randomized (three arms: DOT (standard control), SAT, SAT with SMS reminders) controlled clinical trial.
- Trial name
- iAdhere (NCT01582711)
- Testing
- Self Administered Therapy (SAT), SMS reminders, isoniazid and rifapentine
- Where
- 12 sites in United States, China and 2 more
- Volunteers
- 1,002 people
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections
Determining the Effects of Observed and Self-Administered Drug Regimens in HIV Infected Adults
Highly active antiretroviral therapy (HAART) has led to better health and survival rates among people with HIV/AIDS. The purpose of this study was to measure the effect of trained partner supervision when taking medication versus…
- Trial name
- NCT00608569
- Testing
- Lopinavir/ritonavir, Emtricitabine/Tenofovir disoproxil fumarate, Tenofovir disoproxil fumarate
- Where
- 9 sites in Botswana, Brazil and 6 more
- Volunteers
- 529 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections