Clinical trials: Therapy Effect
Advanced Solid Tumors
A Phase I Study of NTQ1062 in Chinese Patients With Advanced Solid Tumors
This is an open-label, single-arm, phase 1 study to evaluate the safety, tolerability, pharmacokinetics, and preliminary pharmacodynamic effect of NTQ1062 in patients with advanced solid tumors.
- Trial name
- NCT06172309
- Testing
- NTQ1062
- Where
- 2 sites in China
- Volunteers
- 32 people
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
Functional Dyspepsia
Probiotics in Functional Dyspepsia
The goal of this clinical trial is to learn whether a multi-strain probiotic can reduce digestive symptoms and improve quality of life in adults with functional dyspepsia.
- Trial name
- ProPepsis (NCT07276009)
- Testing
- Lactobacillus
- Where
- Ukraine
- Volunteers
- 60 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Healthy Mouth Microbiome
Evaluation of the Mouthwash Effect on Maintaining Healthy Microbiome in Healthy Mouth.
The goal of this study is to learn if mouthwash works to maintain healthy microbiome in subjects with healthy mouth. It will also learn about its safety.
- Trial name
- NCT07844993
- Testing
- Mouthwash
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lacer S.A.
NSCLC
Drug-drug Interaction Study of Gefitinb on Apatinib in NSCLC Patients
The primary objective of the study was to assess the effect of gefitinib on the pharmacokinetics of apatinib mesylate in lung cancer patients.
- Trial name
- NCT04390984
- Testing
- Apatinib Mesylate, Gefitinib
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Diabetes Mellitus
Efficacy of Pioglitazone and Glimepiride Combination Therapy in Treating Subjects With Type 2 Diabetes Mellitus.
The purpose of this study is to determine the effect of pioglitazone, once daily (QD), and glimepiride combination therapy compared to glimepiride monotherapy in subjects with Type 2 Diabetes.
- Trial name
- NCT00770952
- Testing
- Pioglitazone and Glimepiride, Glimepiride
- Where
- 17 sites in Germany
- Volunteers
- 91 people
- Sponsor
- Takeda
Diabetic Foot Ulcer, Ulcer Foot
Resorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data on 2 commercially available SOC dressings treatments for Diabetic Foot Wounds
- Conditions
- Diabetic Foot Ulcer, Ulcer Foot, Diabetic Foot
- Trial name
- NCT03398538
- Testing
- Offloading, Additional (outer) Dressing Application, Mirragen Wound Matrix Dressing
- Where
- 5 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ETS Wound Care, LLC
Healthy
A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the Blood
The trial will be performed to assess the influence of BI 730357 on the pharmacokinetics of caffeine, warfarin, omeprazole and midazolam.
- Trial name
- NCT04679948
- Testing
- Percoffedrinol®, Coumadin®, Antra MUPS®
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
A Study To Evaluate The Effect Of Itraconazole On Pharmacokinetics Of PF-06463922 In Healthy Volunteers
The purpose of this study is to estimate the effect of itraconazole on the single dose pharmacokinetics of PF-06463922 in healthy volunteers in the fasted state.
- Trial name
- NCT02838264
- Testing
- PF-06463922, Itraconazole
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asthma
A Study to Evaluate the Effect of Repeat Doses of GW870086X in Mild to Moderate Asthmatics
This study will measure the effect of repeat inhaled doses of GW870086X on lung function.
- Trial name
- NCT00945932
- Testing
- GW870086X
- Where
- 8 sites in Germany
- Volunteers
- 37 people
- Sponsor
- GlaxoSmithKline
GI Issues, Bowel Movements
The Effect of Humiome® Post LB on Gut COMFort in healthY Adult Volunteers
The goal of this double-blind, randomized placebo-controlled study is to evaluate the effect of an 8-week supplementation of Humiome ® Post LB (170 mg) on bowel movements in healthy adult volunteers compared to Placebo adjusted…
- Conditions
- GI Issues, Bowel Movements, Gastrointestinal Symptoms
- Trial name
- NCT06937814
- Testing
- Humiome ® Post LB
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
PMS, Menstrual Discomfort
An Investigation of Premama Balance and Its Effects on Hormonal Imbalances
An investigation of the dietary supplement marketed as "Premama Balance" on markers of subjective wellbeing in trial participants such as common symptoms of PMS and menstrual symptoms, as well as its effects on aiding in…
- Conditions
- PMS, Menstrual Discomfort, Hormone Disturbance, Menstrual Pain
- Trial name
- NCT05518006
- Testing
- PreMama Balance
- Volunteers
- healthy volunteers welcome
- Sponsor
- Premama Inc.
Hypercholesterolemia, Cardiovascular Disease
Effect of the Plantago Ovata Husk on the Lipid Profile of Patients With Hypercholesterolemia
The hypothesis of this study is that soluble fibre may contribute to a reduction of the low density lipoprotein cholesterol (LDL-c), and the combined effect with a statin may achieve an optimisation of the cholesterol-lowering…
- Trial name
- NCT00502047
- Testing
- Plantago ovata husk
- Where
- Spain
- Volunteers
- 255 people
- Sponsor
- Rottapharm Spain
Type2 Diabetes Mellitus
Safety and Efficacy of Bexagliflozin in Subjects With Moderate Hepatic Impairment
The purpose of this study is to examine the drug exposure and drug effects on subjects with moderate hepatic impairment after a single oral dose of bexagliflozin tablets, 20mg.
- Trial name
- NCT03557658
- Testing
- Bexagliflozin
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Theracos
Diabetes, Diabetes Mellitus, Type 2
Influence on the Effect of an Oral Contraceptive Drug After Administration of Liraglutide in Postmenopausal Women
This trial is conducted in Europe. The aim of this trial is to investigate if liraglutide changes AUC (area under the curve) of ethinylestradiol and levonorgestrel administered as a combination contraceptive drug (Neovletta®).
- Trial name
- NCT01508858
- Testing
- liraglutide, levonorgestrel / ethinylestradiol
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Novo Nordisk A/S
Stroke Gait Rehabilitation
The Effect of Cupping on Spasticity and Function of the Lower Extremity During Rehabilitation After Stroke
Physical therapists use dry static cupping for the treatment of many conditions, including spasticity for patients post-stroke. While research better describes the effects of dry static cupping for patients with orthopedic…
- Trial name
- NCT06653855
- Testing
- Dry Static Cupping, Standard physical therapy treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scott Getsoian
Dengue
Study to Examine the Effects of Oral Fenretinide
This randomized, placebo controlled single center study examines the extent to which 600 mg/m2/day of orally administered ISLA101 (fenretinide), given prophylactically or therapeutically, may reduce or eliminate signs and…
- Trial name
- PROTECT (NCT06528457)
- Testing
- ISLA101, Dengue 1 Live Virus Human Challenge (DENV-1-LVHC)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Island Pharmaceuticals
Huntington's Disease
A Open-label Food Effect Study With SEN0014196 in Subjects With Huntington Disease
The primary purpose of this study is to assess the effect of food upon the pharmacokinetics (PK) of SEN0014196 in subjects with Huntington disease (HD).
- Trial name
- NCT01485965
- Testing
- SEN0014196
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Siena Biotech S.p.A.
Healthy Subject
A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects
The study will investigate the effect of rifampicin on the uptake and breakdown of ACT-246475 in healthy subjects
- Trial name
- NCT03814200
- Testing
- Saline, ACT-246475, Rifampicin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Type 2 Diabetes Mellitus
A Study to Assess the Long-term Safety and Efficacy of ASP1941 in Japanese Diabetic Patients
The primary objective of this study is to evaluate the long-term safety of ASP1941 in patients with type 2 diabetes mellitus. The second objectives are to compare the efficacy and pharmacokinetics of ASP1941 administered before…
- Trial name
- NCT01054092
- Testing
- ipragliflozin
- Where
- 7 sites in Japan
- Volunteers
- 182 people
- Sponsor
- Astellas Pharma Inc
Healthy
Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Metabolism of a Single Dose of Licarbazepine
This study will assess the influence of moderate hepatic impairment on the pharmacokinetics of licarbazepine after single oral administration in healthy subjects and in subjects with stable impaired hepatic function.
- Trial name
- NCT00424671
- Testing
- Licarbazepine
- Where
- Czechia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis
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