Clinical trials: Therapy Effect
Cancer
Bioavailability and Food Effect Study of Gelatin Formulation and Immediate Release Tablet Formulation of Afuresertib
This study is being conducted to measure the relative bioavailability of the original gelatin capsule formulation and a new formulation, immediate release (IR) tablet of Afuresertib (GSK2110183).
- Trial name
- NCT02040480
- Testing
- GSK2110183 Gelatin Capsule, GSK2110183 IR Tablet
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Abdominal Pain
Study to Evaluate Bioactive Peptides' Effect on Digestive Discomfort Symptoms of the Elderly
This trial will investigate the potential of a bioactive peptide to reduce symptoms of digestive discomfort in a generally healthy elderly population.
- Trial name
- Inflammaging (NCT04450979)
- Testing
- Bioactive hydrolysate
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Functional Bloating
Effect of Bacillus Subtilis ATCC 122264 Supplementation on Gas Symptoms and Quality of Life in Participants With Functional Bloating
A randomized, double blind, placebo-controlled, 2-arm parallel study to evaluate the efficacy of Bacillus subtillis in providing relief and improving quality of life in participants suffering from functional abdominal…
- Trial name
- NCT06308146
- Testing
- Bacillus subtilis ATCC 122264
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kerry Group P.L.C
Sepsis
To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053)
To collect clinical response data with the use of ertapenem in community acquired sepsis.
- Trial name
- NCT00397956
- Testing
- MK0826, ertapenem sodium / Duration of Treatment: 14 Days
- Volunteers
- 30 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Diseases
The Acute Effect of 2 Different Serving Regimens of Theobromine on Physiological Effects
The main aim of this study is to determine whether there is a difference in the physiological effects of theobromine when provided via a single serving compared to multiple servings adding up to the same amount of theobromine…
- Trial name
- NCT01544829
- Testing
- Theobromine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
COPD, Sepsis
Effect of Nebulized Bronchodilators on Heart Rate
The purpose of the study is to determine adverse events rates of nebulized albuterol versus levalbuterol among adult critically ill patients and determine if a differential exists in adverse events between the two drugs.
- Conditions
- COPD, Sepsis, Shock
- Trial name
- NCT01151579
- Testing
- Levalbuterol, Albuterol
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Fahim Khorfan, MD
Cervical Intraepithelial Neoplasia
Safety and Protective Effect Study of GSK Biologicals' Human Papillomavirus (Types 16, 18) Vaccine, Adsorbed (GSK580299) in Healthy Female Subjects From the HPV-039 Study
This study was designed to enable all subjects who received placebo in the HPV-039 study (NCT00779766), to also receive GSK Biologicals' Human Papillomavirus (Types 16, 18) Vaccine, Adsorbed.
- Trial name
- NCT03629886
- Testing
- HPV (Types 16, 18) Vaccine, Adsorbed
- Where
- 4 sites in China
- Volunteers
- 6,051 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diabetic Neuropathy
The Effect of Ruboxistaurin on Small Fiber Function
To determine the effect of Ruboxistaurin on small fiber function.
- Trial name
- NCT00190970
- Testing
- Ruboxistaurin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Chromaderm, Inc.
Metastatic/Recurrent Breast Cancer
Pharmacokinetic Study of Tesmilifene (YMB1002) Plus Epirubicin and Cyclophosphamide in Metastatic Breast Cancer
This is a Phase I, multi-centre, open-label, cross-over pharmacokinetic study designed to investigate whether the co-administration of a fixed dose of tesmilifene alters the plasma pharmacokinetics of a standard regimen of…
- Trial name
- NCT00364754
- Testing
- Tesmilifene (YMB 1002)
- Where
- 10 sites in Georgia, Russia and 1 more
- Volunteers
- 28 people
- Sponsor
- YM BioSciences
Symptomatic Neurogenic Orthostatic Hypotension
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH)…
- Trial name
- RESTORE (NCT02586623)
- Testing
- Droxidopa capsules
- Where
- 168 sites in United States
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Overweight, Obesity
Study of Gelesis100 on Body Weight in Overweight and Obese Subjects With and Without Type 2 Diabetes
This study will asses the decrease in body weight after repeated administration of Gelesis100 in overweight and obese subjects with and without Type 2 Diabetes.
- Trial name
- NCT02307279
- Testing
- Gelesis100
- Where
- 36 sites in United States, Canada and 4 more
- Volunteers
- 436 people
- Sponsor
- Gelesis, Inc.
Overactive Bladder, Pharmacokinetics
A Clinical Study to Determine the Effect of YM178 on the Pharmacokinetics of Warfarin in Healthy Subjects
This study investigates whether YM178 has an effect on the pharmacokinetics of warfarin, to exclude any drug-drug interaction between YM178 and warfarin, and evaluates the safety and tolerability of warfarin alone and combined…
- Trial name
- NCT00856570
- Testing
- warfarin, YM178
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy
A Study to Investigate How AZD4144 Affects the Pharmacokinetics of Rosuvastatin in Healthy Participants
The purpose of this study is to evaluate the pharmacokinetics (PK) of rosuvastatin when administered alone and in combination with single oral dose of AZD4144.
- Trial name
- NCT06925854
- Testing
- AZD4144, Rosuvastatin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Non-small-cell Lung Carcinoma
Study Investigating the Effect of Everolimus Monotherapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
This study will evaluate the efficacy and safety of everolimus treatment of patients with advanced NSCLC. The rationale for investigating everolimus in advanced NSCLC previously treated with chemotherapy or chemotherapy plus EGFR…
- Trial name
- NCT00124280
- Testing
- RAD001
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Novartis Pharmaceuticals
Obesity, Overweight
A Study of the Safety and Efficacy of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Overweight and Obese Subjects
The purpose of this study is to determine whether 2 doses of the combination of naltrexone SR and bupropion SR are safe and effective in the treatment of obesity.
- Trial name
- NCT00532779
- Testing
- Naltrexone SR 16 mg/Bupropion SR 360 mg /day, Naltrexone SR 32 mg/Bupropion SR 360 mg /day, Ancillary therapy
- Where
- 34 sites in United States
- Volunteers
- 1,742 people
- Sponsor
- Orexigen Therapeutics, Inc
Infectious Disease, Children, Only
Effect of Prebiotic Fructans to Reduce Number of Febrile Infections in Children
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on the reduction of the number of febrile infections diagnosed by the paediatrician in children.
- Conditions
- Infectious Disease, Children, Only, Diet Modification
- Trial name
- NCT03457688
- Testing
- prebiotic inulin-type fructans
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Hepatitis C
VX-950-TiDP24-C136 - A Trial to Evaluate the Effect of Telaprevir (TVR) on the Results of Electrocardiograms (Electric Recording of the Heart) in Healthy Volunteers
The purpose of this study is to evaluate the effect of telaprevir on the results of electrocardiograms in healthy volunteers. An electrocardiogram is an electric recording of the heart.
- Trial name
- NCT00973388
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Healthy
Evaluate the Effects of Food on the Pharmacokinetics of Fadanafil in Healthy Subjects
The purpose of this study is to evaluate the effect of high fat meal on the pharmacokinetics of single oral fadanafil tablet 100mg in healthy subjects. Fadanafil is a selective phosphodiesterase (PDE5) inhibitor.
- Trial name
- NCT04467203
- Testing
- Fadanafil
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sihuan Pharmaceutical Holdings Group Ltd.
Cognitive Ability, General
The Effect of Feeding Infant Formula With Enriched Protein Fractions
This study is intended to evaluate the nutritive effects of study formulas on growth and cognitive outcomes.
- Trial name
- NCT02274883
- Testing
- Enriched Protein Fractions, Protein Fractions
- Where
- 3 sites in China
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Diabetic Peripheral Neuropathy
Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study
To determine if pulsed electric field therapy reduces lower leg and foot pain associated with diabetic neuropathy and lessens the need for medication.
- Trial name
- DPN (NCT00614341)
- Testing
- MedRelief SE 55
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- MedRelief
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