Clinical trials: Therapy Effect
Hamstring Injury, Muscle Rupture
Effect of NMES+ on Hamstring Lesion (3a/3b)
The goal of this clinical trial is to analyze the effect of the electrical stimulation superimposed onto movement in healthy semi-professional athletes who sustained a type 3a/3b hamstring strain injury.
- Conditions
- Hamstring Injury, Muscle Rupture, Hamstring Sprain
- Trial name
- NCT05786300
- Testing
- NMES+, Rehab
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
Core Stabilization, Respiration
Core Stabilization Training on Chest Expansion, Functional Capacity, Trunk Muscle Endurance in Hearing-Impaired Children
Children's motor skills and physical performance increase with age due to the development of neuromuscular and cardiorespiratory systems.
- Conditions
- Core Stabilization, Respiration, Functional Capacity, Endurance
- Trial name
- NCT06354400
- Testing
- Core stabilization training
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Bezmialem Vakif University
Colon Cancer, Rectum Cancer
The Effect of Art Therapy in Patients Undergoing Colorectal Cancer
With the development of modern techniques, art has become important in the provision of health services and has enabled individuals to better recognise themselves and their surroundings.
- Trial name
- NCT07137000
- Testing
- Art therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Saglik Bilimleri Universitesi
Gestational Diabetes, Continuous Glucose Monitoring
The Effect of Continuous Glucose Monitoring on Glycemic Control and Pregnancy Outcomes in Gestational Diabetes Mellitus
The purpose of this study is to determine if Continuous glucose monitoring improves glycemic control and pregnancy outcomes of Gestational Diabetes Mellitus
- Trial name
- NCT03955107
- Testing
- Continuous Glucose Monitoring System
- Where
- China
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Open-Heart Surgery
Development of Delirium in Patients Undergoing Open-Heart Surgery
Malnutrition is a prevalent issue among patients undergoing cardiac surgery. This can lead to delirium risk factors, including postoperative functional and cognitive impairment.
- Trial name
- NCT06195592
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubra Gunes
Idiopathic Dilated Cardiomyopathy
Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart
The primary goal of the study is to measure in the intact human heart, the alterations in gene expression over time that are associated with reverse remodeling in response to β-blockade.
- Trial name
- BORG (NCT01798992)
- Testing
- Carvedilol, Metoprolol succinate, Metoprolol succinate + doxazosin
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes
The Effect of Januvia (Sitagliptin) on Oxidative Stress in Obese Type 2 Diabetic Subjects
Sitagliptin is a new oral hypoglycemic anti-diabetic drug used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus.
- Trial name
- 1928 (NCT00659711)
- Testing
- Januvia (Sitagliptin) 100 mg
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University at Buffalo
Intradialytic Hypotension, Hemodialysis
Effect of Breathing Exercise on Intradialytic Hypotension in Hemodialysis Patients
Intradialytic hypotension is a common complication of hemodialysis that may adversely affect patient safety and treatment tolerance.
- Trial name
- NCT07773311
- Testing
- Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Yasemin Çelik
Healthy Participants
Evaluate the Effects of Food on the Pharmacokinetics of SIM0270
This is a randomized, open label, single dose, two-period, crossover trial phase I study. The purpose of this study is to evaluate the food effect on the pharmacokinetics（PK） of SIM0270 after oral administration under fasted…
- Trial name
- NCT06536036
- Testing
- SIM0270
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Kidney Transplantation
Effect of Privigen Against Graft Loss
The principal objective of this pilot study is to determine whether the progression of chronic antibody-mediated rejection (ABMR) could be minimized by the post-transplant administration of high dose of Intravenous…
- Trial name
- InAuGuRAL (NCT02374736)
- Testing
- Privigen (Human normal immunoglobulin G (IgG > 98 % purity))
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Subjects
Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects
This was a single-center study using induced blood stage malaria infection to characterize the activity of ACT-451840 against early Plasmodium falciparum blood stage infection
- Trial name
- NCT02223871
- Testing
- ACT-451840:, Plasmodium falciparum-infected human erythrocytes:, Artemether 20 mg and lumefantrine 120mg combination tablet:
- Where
- Australia
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
End Stage Renal Disease (ESRD)
Effect of Medium Cut-Off Hemodialysis on Protein Energy Wasting: The EMCOPEW Study
In patients on maintenance hemodialysis (HD), protein energy wasting (PEW) defined as loss of muscle mass and fuel reserves of the body is frequent and associated with severe morbidity and mortality.
- Trial name
- EMCOPEW (NCT05309109)
- Testing
- Hemodialysis sessions
- Where
- 2 sites in France
- Volunteers
- 65 people
- Sponsor
- Poitiers University Hospital
Healthy
Safety, Tolerability and Pharmacokinetics of Oral BIBP 5371 CL in Healthy Male and Female Volunteers
Safety, tolerability and pharmacokinetics (including comparisons of different formulations and investigation of food effect)
- Trial name
- NCT02256709
- Testing
- BIBP 5371 CL tablet, BIBP 5371 CL solution, High fat, high caloric breakfast
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Gingival Recession, Platelet Derived Growth Factor
Recombinant Human Platelet-derived Growth Factor in Combination With Collagen Matrix
The present randomized clinical trial is aimed at evaluating the efficacy of recombinant human platelet-derived growth factor in combination with collagen matrix for the treatment of multiple adjacent gingival recessions
- Trial name
- NCT04462237
- Testing
- Root coverage procedures
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Aortic Valve Stenosis, Aortic Diseases
PENG Block forTranscatheter Aortic Valve Implantation
Pericapsular nerve group (PENG block) is a new fascial block defined by Arango et al. This block aims to block the femoral nerve and the accessory obturator nerve by injecting local anesthetic between the pubic ramus and psoas…
- Trial name
- NCT05904912
- Testing
- Postoperative analgesia management, PENG-Bupivacaine, Local infiltration-Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Healthy
Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volunteers Receiving Delayed-release Dimethyl Fumarate
The primary objective of the study is to evaluate whether premedication with 325 mg microcoated aspirin (ASA) tablet or a slow-titration dosing schedule of BG00012 reduces the incidence and severity of flushing and GI events…
- Trial name
- NCT01568112
- Testing
- BG00012 (dimethyl fumarate), ASA
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Biogen
Postmenopausal Osteoporosis
Pravastatin Reduces Acute Phase Response of Zoledronic Acid
Acute phase response (APR) is one of the most common adverse events in osteoporosis with zoledronic acid treatment. It's reported that this reaction is related to the blockade of the mevalonate pathway, leading to isopentenyl…
- Trial name
- NCT04719481
- Testing
- Pravastatin Sodium 80 MG
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Mild Cognitive Impairment
Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography)
A six month, placebo-controlled, parallel group project in which MCI participants will receive 30 g/day of a custom-made MCT-based ketogenic supplement or a matching placebo.
- Trial name
- BENEFIC (NCT02551419)
- Testing
- ketogenic drink
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Université de Sherbrooke
Allergic Asthma
Efficacy of Omalizumab in Adults (18-60 Years of Age) With Moderate-Severe, Persistent Allergic Asthma, Despite Receiving Inhaled Corticosteroids and Long Acting Beta-agonists
This study aims to investigate the effect of omalizumab on the number of tissue eosinophils and other markers of airway inflammation and remodeling, including thickness of the lamina reticularis, in moderate to severe asthmatics…
- Trial name
- eXplore (NCT00670930)
- Testing
- omalizumab at a dose of 0.016mg/kg/IU/mL
- Where
- 16 sites in United States, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Novartis Pharmaceuticals
Stress Related Disorder, Musculoskeletal Pain
Immediate Effect of Energy Alignment and Mantra on Stress Related Pain in Adolescents
Psychiatrists have expressed concern at the emergence of education as a serious source of stress for school-going children - causing high incidence of deaths by suicide.
- Conditions
- Stress Related Disorder, Musculoskeletal Pain, Headache
- Trial name
- NCT03308630
- Testing
- Yoga based Energy Alignment and Mantra
- Where
- India
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- NMP Medical Research Institute
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