Clinical trials: Thermal Burn
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Burns
The Effects of Viscoelastometry Guided Resuscitation During Burn Excision on Post Resuscitation Infections
This is a randomized controlled trial to compare viscoelastometric (VE) guided transfusion to standard practice transfusion in severe thermal injury burn excision on the utilization of blood products, effects on coagulation and…
- Trial name
- NCT03730415
- Testing
- Viscoelastic (VE) Guided Transfusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Pain
Reducing Brief Thermal and Electrical Pain (Four Study Days)
Ultimately, the purpose of the present study is to help improve pain control in burn patients during wound care and physical therapy, where pain levels with opioids alone are often excessively high.
- Trial name
- 4DO (NCT00682682)
- Testing
- Virtual Reality video distraction, Virtual Reality video game
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Washington
Erythema
Efficacy of Dexpanthenol in Thermic Erythema
The study focuses to prove the equivalent efficacy of two different Dexpanthenol formulations.
- Trial name
- NCT00839462
- Testing
- Dexpanthenol foam spray, new formulation, Dexpanthenol foam spray, old formulation
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Bayer
Burns, Electric Burns
Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns
Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue.
- Trial name
- NCT00812513
- Testing
- R-Pdf/Gbb 0.01% gel
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- American Scitech International
Burns Second Degree
Thermal Imaging and Pediatric Burns
The need to cover a burn with a skin graft is determined primarily by its depth. In fact only burns of the second deep degree or the third degree are likely to be grafted.
- Trial name
- FLIRPED (NCT03702972)
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Inflammation
Hyperbaric Oxygen Therapy Attenuates Central Sensitization Induced by a Thermal Injury in Human Volunteers (HBO)
The hypothesis of this investigation is to observe if HBO have an anti-inflammatory effect in humans induced by tonic heat stimulation.
- Conditions
- Pain, Inflammation, Hyperalgesia
- Trial name
- NCT02025686
- Testing
- Hyperbaric Oxygen, Normal ambient conditions
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Per Rotbøll Nielsen
Thermal Hyperalgesia, Anxiety
A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients
Burn-related pain is severe and often difficult to manage. Healthcare workers struggle with keeping burn patients comfortable, especially when these patients undergo dressing changes of their burn wounds of their skin since these…
- Conditions
- Thermal Hyperalgesia, Anxiety, Pain
- Trial name
- NCT02336308
- Testing
- Ketamine
- Where
- United States
- Sponsor
- University of Colorado, Denver
Stress, Burn Out
Effects of a Thermal Spa Short Residential Program for Prevention of Work-related Stress / Burn-out on Biomarkers of Stress - A Proof of Concept Study
Work-related stress is a public health issue. Among the multiple physical and psychological consequences of stress, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Stress, Burn Out, Heart Rate Variability
- Trial name
- ThermStress (NCT03536624)
- Testing
- 6 days spa residential program
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Thermal Burn
Feasibility of Obtaining ADRCs From Discarded Thermal Burn Eschar Tissue Using Investigational Celution® System
The objective of the study is to assess the logistical and biological feasibility of preparing ADRCs from adipose tissue excised during standard-of-care burn wound excision using the Celution® System for autologous, same-day…
- Trial name
- NCT02362386
- Testing
- Celution Device
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cytori Therapeutics
Thermal Burns
A Safety, Tolerability and Pharmacokinetic Study of cP12 in Adults With Up To 10% Total Body Surface Area Burns
This is a Phase 2a, open-label, single-dose study to evaluate the safety, tolerability, and PK profile of cP12 in 6 male and female subjects with thermal burns of up to and including 10% TBSA.
- Trial name
- NCT06814717
- Testing
- cP12
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Neomatrix Therapeutics, Inc.
Burns
The RE-ENERGIZE Study: RandomizEd Trial of ENtERal Glutamine to minimIZE Thermal Injury
The purpose of this study is to test the following hypotheses: 1. Enteral glutamine administration decreases in-hospital mortality in adult patients with severe thermal burn injuries. 2.
- Trial name
- RE-ENERGIZE (NCT00985205)
- Testing
- Enteral Glutamine
- Where
- 53 sites in United States, Austria and 12 more
- Volunteers
- 1,201 people
- Sponsor
- Daren K. Heyland
Inhalation Injury
Wii Aerobic Training in Inhalation-injury Children Post-thermal Burn
Inhalation injury is a composite of multiple insults including: supra glottic thermal injury, subglottic airway and alveolar poisoning, and systemic poisoning from absorbed small molecule toxins.
- Trial name
- NCT06326593
- Testing
- Wii aerobic training, conservative chest care
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- MTI University
Thermal Burns
A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
This study will be a three-arms study intending to demonstrate superiority of NexoBrid treatment over the Gel Vehicle placebo control treatment and over SOC in thermal burn subjects. The study objectives are: 1.
- Trial name
- NCT02148705
- Testing
- NexoBrid, Standard of Care (SOC), Gel Vehicle
- Where
- 29 sites in United States, Belgium and 6 more
- Volunteers
- 175 people
- Sponsor
- MediWound Ltd
Burns, Skin Burn Requiring Skin Graft
Study of Low Adherent Dressing Versus the Standard of Care for the Management of Skin Grafts Over Thermal Burns
The purpose of this study is to evaluate the P6 Low Adherent Study Dressing relative to the Standard of Care (SOC, Mafenide Acetate 5% Solution) for the management of skin grafts in burn wounds resulting from thermal burn…
- Trial name
- NCT01654094
- Testing
- P6 Low Adherent Dressing, Standard of Care (SOC)
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Milliken Healthcare Products, LLC
Burn, Chronic Pain Following Thermal Burn Injury
VR-PMR for Post-Burn Symptoms
The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep…
- Conditions
- Burn, Chronic Pain Following Thermal Burn Injury, Non-Pharmacological Interventions, Virtual Reality
- Trial name
- VIBE (NCT07317271)
- Testing
- Virtual Reality-Enhanced Progressive Muscle Relaxation, Standard Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Deep Partial-thickness Burn
StrataGraft® Skin Tissue Expanded Access at Specific Study Sites ( StrataCAT )
An autograft is a piece of skin taken from a healthy area of the body to be used to treat severe burns on another part of the same body.
- Trial name
- NCT04123548
- Testing
- StrataGraft skin tissue
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Shock, Thermal Burn
VItamin C in Thermal injuRY: The VICToRY Trial
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery.
- Trial name
- VICToRY (NCT04138394)
- Testing
- Ascorbic Acid
- Where
- 33 sites in United States, Belgium and 7 more
- Volunteers
- 666 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Acute Thermal Burns
The Effects of Hyperbaric Oxygen Therapy (HBOT) on Acute Thermal Burns
The blinded RCTstudy aims to: Determine the effects of HBOT on burns conversion for patients who have fresh thermal burns injury using the LDI.
- Trial name
- NCT00824551
- Testing
- Hyperbaric Oxygen Therapy, Standard care
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Singapore General Hospital
Burn Injury, Thermal Burn
Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial
The Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) trial will be a 5-year (3-year enrollment), open label, phase-3, multi-center, early in-hospital phase randomized trial…
- Trial name
- PREEVEnT (NCT07212998)
- Testing
- Plasma, Standard care
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Jason Sperry