Clinical trials: Thermal Burn
Chronic Pain Following Thermal Burn Injury
Vitamin D and n-3 Polyunsaturated Fatty Acids (PUFAs) to Prevent Chronic Pain Following Major Thermal Burn Injury
The goal of this study is to develop a safe, effective, and readily available treatment that will prevent chronic pain following Major Thermal Burn Injury (MThBI).
- Trial name
- NCT03313076
- Testing
- Omega-3 fatty acids (fish oil), Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Burns
Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group
The primary objective is to compare the effectiveness of treatment with Sulfamylon® solution as the initial topical moist dressing over meshed autografts following the initial graft procedure on preventing graft loss in a…
- Trial name
- NCT00634166
- Testing
- Sulfamylon® For 5 % Topical Solution, Topical Antimicrobial/Antifungal Medications
- Where
- 9 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mylan Inc.
Thermal Burns
Continuous Lidocaine Infusion for Management of Perioperative Burn Pain
Thermal injury results in one of the most intense and prolonged forms of pain the body can experience. Opioid narcotics are the most powerful drugs for acute and chronic pain, and their use in the perioperative period has been…
- Trial name
- NCT02059902
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- HealthPartners Institute
Burn, Thermal
StrataGraft® Skin Tissue in the Promotion of Autologous Skin Regeneration of Complex Skin Defects Due to Thermal Burns That Contain Intact Dermal Elements
About 70 participants will be enrolled. They will have complex skin defects because of burns caused by heat. The burns will: be on 3-49% of the participant's total body surface area (TBSA) require surgery for skin replacement…
- Trial name
- NCT03005106
- Testing
- StrataGraft Skin Tissue, Autograft
- Where
- 16 sites in United States
- Volunteers
- 71 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Thermal Burns
A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
This study will be a three-arms study intending to demonstrate superiority of NexoBrid treatment over the Gel Vehicle placebo control treatment and over SOC in thermal burn subjects. The study objectives are: 1.
- Trial name
- NCT02148705
- Testing
- NexoBrid, Standard of Care (SOC), Gel Vehicle
- Where
- 29 sites in United States, Belgium and 6 more
- Volunteers
- 175 people
- Sponsor
- MediWound Ltd
Deep Partial-thickness Burn
StrataGraft® Skin Tissue Expanded Access at Specific Study Sites ( StrataCAT )
An autograft is a piece of skin taken from a healthy area of the body to be used to treat severe burns on another part of the same body.
- Trial name
- NCT04123548
- Testing
- StrataGraft skin tissue
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Full Thickness Thermal Burn
StrataGraft Overlay of Meshed Autograft in Full-thickness Thermal Burns
Autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. Autografting is the usual treatment for full-thickness (FT) burns.
- Trial name
- StrataSOMA (NCT04765202)
- Testing
- AG Tx, SOMA Tx
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Thermal Burns
A Study to Evaluate the Efficacy and Safety of NexoBrid in Children With Thermal Burns Compared the Standard of Care
This study will be a two-arms study intending to demonstrate superiority of NexoBrid treatment over SOC in children with thermal burns.
- Trial name
- NCT02278718
- Testing
- NexoBrid, Standard of Care
- Where
- 36 sites in United States, Belgium and 12 more
- Volunteers
- 145 people
- Sponsor
- MediWound Ltd
Skin Wound, Burns
StrataGraft Safety, Tolerability and Efficacy in Pediatric Subjects
Autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. Autografting is the usual treatment for DPT burns.
- Conditions
- Skin Wound, Burns, Trauma-related Wound
- Trial name
- StrataSTEPS (NCT05517902)
- Testing
- StrataGraft
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Burns
Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants
This longitudinal, prospective study aims to establish the magnitude and time course of changes in intestinal permeability; establish the optimal method for assessment of intestinal permeability in thermally injured participants…
- Trial name
- NCT03242434
- Testing
- Lactulose and Mannitol solution, Sucralose
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Thermal Burn
Single-Stage Integra Reconstruction in Burns
This is a prospective, descriptive, pilot case series involving patients with significant burns who are candidates for reconstruction with Integra®.
- Trial name
- Integra (NCT03077087)
- Testing
- thin Integra® (125 cm2)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- HealthPartners Institute