Clinical trials: Thermogenesis
Obesity
Effects of Estrogen Deficiency on Energy Expenditure
Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to produce heat.
- Trial name
- NCT01846728
- Testing
- Estrogen suppression
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity
Effect on Energy Metabolism at Cellular Level of Diet Plus Treatment With Ephedrine and Caffeine in Obesity
Brief Summary This trial was part of a sub-project targeted to diet, thermogenesis and obesity of a larger multicentre study named "Interaction between nutritional, social-behavioral and metabolic factors for prevention of…
- Trial name
- NCT02048215
- Testing
- Caffeine, Ephedrine, Hypocaloric diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Istituto Auxologico Italiano
Metabolic Rate, Plasma Glucose
Acute Effects of Different Macronutrient Compositions and Meal Distributions of the Food
About thirty participants, of varying degrees of obesity or being non-obese, without serious concomitant diseases consume either a high- or a low- carbohydrate beverage.
- Conditions
- Metabolic Rate, Plasma Glucose, Serum Insulin, Serum Triglycerides
- Trial name
- DIT2 (NCT02622490)
- Testing
- two test meals with two different macronutrient compositions
- Where
- Sweden
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Healthy
Effects of a Specific Spice on Energy Metabolism
The objective of this study is to examine whether a specific spice is capable of affecting energy metabolism. Since chili and other spices have been shown to increase energy expenditure and in some cases also affect energy…
- Trial name
- NCT00841893
- Testing
- Mustard (dijon)
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Polycystic Ovary Syndrome (PCOS)
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT07896642
- Testing
- inositol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Overweight, Obesity
Role of Dietary Protein on Satiety, Food Intake and Thermic Effect of Food
Objectives: To determine the effect of protein content of familiar breakfast meals on subjective appetite, food intake (FI), glycemic response and Thermic Effect of Food (TEF) in normal weight (NW) and overweight (OW)/obese (OB)…
- Trial name
- NCT02200796
- Testing
- Control Meal, Low Protein Meal, Moderate Protein Meal
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Brown Adipose Tissue
Short Term Effect of Glucocorticoids on Brown Adipose Tissue Thermogenesis in Humans
Interventional, Placebo controlled cross-over study to investigate the short-term effects of glucocorticoids (prednisone) on human brown adipose tissue.
- Trial name
- GlucoBAT (NCT03269747)
- Testing
- Prednisone
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Metabolic Disease
mTORC1 and Autophagy in Human Brown Adipocytes
The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults.
- Trial name
- mTORHBFC (NCT04206124)
- Testing
- Brown Fat Harvest During Anterior Neck Surgery
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Background: Changes in how a person's body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate.
- Trial name
- NCT01950520
- Testing
- Propranolol, Pindolol, Dantrolene
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight, Obesity
NEAT - Prevention and Treatment of Overweight and Obesity.
This study will investigate the effect on Non-exercise Activity Thermogenesis (NEAT) when implementing active workstation at offices compared to conventional office work.
- Trial name
- InphactUm (NCT01997970)
- Testing
- Treadmill workstation, Health talk
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Umeå University
Cold Exposure
The Effect of Cold Exposure on Energy Expenditure
Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health.
- Trial name
- NCT05107570
- Testing
- Cold exposure
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Obese Adults
Evaluation of the Effects of Systemic Vibration Therapy on Thermogenesis, Cardiovascular Parameters, Endocrine-inflammatory Markers, and Physical-functional Performance in Adults With Obesity.
The goal of this clinical trial was to evaluate the effects of Systemic Vibration Therapy (SVT) on thermogenesis, cardiovascular health, endocrine-inflammatory markers, and physical performance in adults (men and women, aged…
- Trial name
- SVT (NCT07729215)
- Testing
- Systemic vibratory therapy, Systemic vibration therapy
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Laboratorio de Vibraçoes Mecanicas e Praticas Integrativas
Overweight
Whey Protein Micelles and Thermogenesis in Overweight Subjects
The main objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels. It will be a randomized crossover double-blind design conducted in 20 subjects.
- Trial name
- Thermowhey (NCT02303080)
- Testing
- Control (WPM 0), WPM 30, WPM 50
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Thermoregulation Impairment
Glucocorticoid Long-term Administration: Effect on Cold Induced Energy Expenditure and Resting Metabolic Rate
The aim of the study is to investigate whether treatment with glucocorticoids leads to a change in heat production of the human body at mild cold conditions.
- Trial name
- GLACIER (NCT03949361)
- Testing
- Indirect calorimetry, Skin Temperature, Dual energy X-ray Absorptiometry (DXA)
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Overweight/Obese
Shivering and Glucose Homeostasis
The purpose of this study is to investigate the effect of prolonged shivering thermogenesis on glucose homeostasis in overweight/obese humans.
- Trial name
- NCT04516018
- Testing
- Cold exposure
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University
Imbalance of Constituents of Food Intake, Healthy
The Effect of Phosphorus on Diet Induced Thermogenesis
The aim of the trial is to investigate the effect of ingestion of 75g of glucose (with or without phosphorus) on diet induced thermogenesis (using indirect calorimetry) and appetite (using visual analogue scales) in lean and…
- Trial name
- NCT02594787
- Testing
- Phosphorus
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lebanese American University
Overweight, Obesity
Energy Expenditure and Substrate Oxidation in a Whole Room Calorimeter
The investigators aim to establish a protocol for metabolic rate measurements obtained using continuous monitoring of oxygen consumption and carbon dioxide production in a whole room calorimeter setting.
- Conditions
- Overweight, Obesity, Body Weight
- Trial name
- NCT04061369
- Testing
- Low fat meal, Moderate fat meal, High fat meal
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diet Induced Thermogenesis
Effect of Allulose on Diet-induced Thermogenesis
The objective of this study is to investigate the dose-response effect of allulose on diet-induced thermogenesis, substrate oxidation, glycemic response, and subjective appetite in healthy normal weight adults.
- Trial name
- NCT06515340
- Testing
- Allulose Dose 1, Allulose Dose 2, Allulose Dose 3
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Obesity, Weight
Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate
A 4 week intake of drug to find a natural substance that may modify energy balance and may enhance health in combination with lifestyle changes with possible decrease in body weight.
- Trial name
- CAPSPAL (NCT00999297)
- Testing
- Dihydrocapsiate
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity and Overweight
How Metabolism Affects Weight Loss and Gain
This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight.
- Trial name
- NCT06860776
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein