Clinical trials: Third Molar
Stem Cell, Third Molar
Effect of Dental Pulp Stem Cells and L-PRF After Impacted Third Molar Extraction
The purpose of this study is to compare the clinical and radiographic effectiveness of Leukocyte-Platelet Rich Fibrin (L-PRF) and L-PRF combined with dental pulp stem cell (DPSC) application to the extraction socket of mandibular…
- Conditions
- Stem Cell, Third Molar, Periodontal Pocket
- Trial name
- NCT04641533
- Testing
- L-PRF + DPSC, L-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Baskent University
Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.
- Trial name
- NCT06713733
- Testing
- Dexamethasone, Chymotrypsin
- Where
- Nepal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Postsurgical Pain, Third Molar Extraction
Efficacy and Safety of APSCTC for the Treatment of Postsurgical Pain Due to Third Molar Extraction
The purpose of this study is to evaluate the efficacy of APSCTC compared to two active drugs in acute pain relief.
- Trial name
- CARLOTA (NCT04647435)
- Testing
- APSCTC, Toragesic®, Tramal®
- Where
- Brazil
- Volunteers
- 396 people, healthy volunteers welcome
- Sponsor
- Apsen Farmaceutica S.A.
Impacted Third Molar
Comparative Effects of CGF and PRP in Impacted Third Molar Surgery
This study evaluates the effects of two different blood products obtained from the patient's own blood (Concentrated Growth Factor [CGF] and Platelet-Rich Plasma [PRP]) on healing after wisdom tooth extraction.
- Trial name
- NCT07320170
- Testing
- Concentrated Growth Factor (CGF), Platelet-Rich Plasma (PRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Recep Tayyip Erdogan University
Dry Socket
Prevention of Dry Socket by Means of Single Preoperative Antibiotics Compared to Conventional Therapy
Background: One of the commonest post-operative complications after tooth extraction is dry socket; it can be defined as postoperative pain in and around the tooth extraction site, which increases in severity at any time between…
- Trial name
- NCT03992144
- Testing
- Amoxicillin 500 Mg, metronidazole 400mg, metronidazol 400mg and amoxicillin 500mg
- Where
- Pakistan
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Oral Health Care
The Effect of Supplementary Foods Containing Trypsin, Chymotrypsin and Serratia Peptidase on Healing After Impacted Wisdom Tooth Surgery
Introduction: The aim of this study was to determine the effects of a dietary supplement containing trypsin, chymotrypsin, and serratia peptidase (Tripser Forte N30, Incir Pharma, Turkey) on postoperative healing and to determine…
- Trial name
- Trypsin (NCT07269171)
- Testing
- Pain Assessment, Number of Analgesics Needed, Edema Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Pain and Sensation Disorder, Pain, Postoperative
Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing…
- Trial name
- NCT04860141
- Testing
- Gabapentin 600mg
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Pericoronitis
Evaluation of Photodynamic Therapy in Pericoronitis
In order to reduce the chances of systemic dissemination of the infection and the use of antibiotics, it is mandatory to test effective treatments in the initial phase of pericoronitis aiming to avoid the evolution of the…
- Trial name
- pdt (NCT03576105)
- Testing
- irrigation /sterile saline, Conventional methylene blue as photosensitizer, Methylene blue for oral use as photosensitizer
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Impacted Third Molar Tooth
Effect of Using Irrigations at Different Temperatures on Postoperative Period During the Extraction of Impacted Mandibular Molars
An Evaluation of the Effect of Using Irrigations at Different Temperatures on Pain, Edema, and Trismus During the Extraction of Bilateral Impacted Mandibular Third Molars: A Randomized Split-Mouth Clinical Trial
- Trial name
- NCT06020053
- Testing
- saline irrigation at various temperatures (4°C, 25°C)
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Firat University
Healthy, Inflammation
Cyclooxygenase Levels Following Surgery to Remove Third Molars (Wisdom Teeth)
This study will measure levels of an enzyme called cyclooxygenase in gum tissue following third molar (wisdom tooth) extraction. Cyclooxygenase is thought to contribute to pain that normally follows tissue injury or surgery.
- Trial name
- NCT00006175
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Third Molar Surgery, Impacted Third Molar Tooth
Impact of 3D Intraoral Scanning on Postsurgical Evaluation of Mandibular Third Molar Surgery
The aim of this study was to analyze the effectiveness of piezoelectric surgery and traditional rotating device in reducing perioperative sequelae after impacted mandibular third molar surgery in 56 subjects.
- Trial name
- NCT05684601
- Testing
- Third molar surgery
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Catania
Impacted Third Molar Tooth, PAIN
An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery
Randomised control clinical trial to compare which combination of analgesics in effective in pain management after third molar extraction of wisdom teeth.
- Trial name
- NCT04874675
- Testing
- diclofenac / acetaminophen /codeine, ibuprofen/acetaminophen/codeine
- Where
- Zimbabwe
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Pain, Post-Operative Pain
Ibuprofen Extended-Release Dental Pain Study
The purpose of this study is to evaluate the efficacy and safety of multiple doses of Ibuprofen 600 mg Extended-Release Tablets in a study of dental pain following extraction of third molar teeth.
- Conditions
- Pain, Post-Operative Pain, Third Molar Extraction
- Trial name
- NCT00707057
- Testing
- Ibuprofen 600 mg Extended-Release Tablets
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- SCOLR Pharma, Inc.
Post Operative Pain
Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third Molars
1. To compare the postoperative pain between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 2.
- Trial name
- NCT05681312
- Testing
- systemic proteolytic enzyme (Tibrolin), Amoxicillin 500mg+metronidazole 500mg+ doliprane 100mg
- Where
- Iraq
- Volunteers
- 55 people
- Sponsor
- University of Baghdad
Impacted Mandibular Third Molar, Postoperative Wound Healing
Soft Tissue Healing and Bacterial Load With Triclosan-Coated Sutures After Impacted Mandibular Third Molar Surgery
The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the…
- Trial name
- NCT07386366
- Testing
- Triclosan-coated Polyglactin 910 suture, Non-coated polyglactin 910 suture
- Where
- Vietnam
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Inferior Alveolar Nerve Injuries
Orthodontic Extrusion of High Risk Impacted Mandibular Third Molar
The goal of this clinical trial is to investigate the usage of maxillary miniscrew and cross-arch elastics for the orthodontic traction of the impacted mandibular third molar in close proximity to the inferior alveolar nerve to…
- Trial name
- NCT06538688
- Testing
- Orthodontic extrusion of the impacted mandibular third molar by using the maxillary miniscrew and cross arch elastic power chain as a temporary anchorage device before extraction
- Where
- 3 sites in Egypt
- Volunteers
- 9 people
- Sponsor
- Alexandria University
Trismus, Swelling
Efficacy Evaluation of the (Serodase 5 mg Tablet) in the Treatment of Inflammation After Third Molar Surgery
The purpose of this study is to examine the efficacy of dose regimen of serratiopeptidase (serodase 5 mg) as a prospective, randomized, parallel, double blind Placebo- controlled study.
- Conditions
- Trismus, Swelling, Inflammation
- Trial name
- NCT02493179
- Testing
- Serodase 5 mg
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Hayat Pharmaceutical Co. PLC
Facial Swelling, Tooth Position Anomalies
Platelet-Rich Fibrin as an Antibiotic Delivery Vehicle in Mandibular Third Molar Surgery
The present study aims to evaluate the effect of platelet-rich fibrin (PRF) used as a local antibiotic delivery vehicle on postoperative outcomes, including facial swelling, trismus, and pain, following mandibular third molar…
- Conditions
- Facial Swelling, Tooth Position Anomalies, Tooth, Impacted, Tooth Extraction Status Nos
- Trial name
- NCT07764757
- Testing
- Antibiotic-enriched Platelet-Rich Fibrin (PRF), Platelet-Rich Fibrin (PRF)
- Where
- Italy
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Amerigo Giudice
Impacted Third Molar Tooth
The Effect of Melatonin Application Following Removal of Impacted Third Molar
In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic…
- Trial name
- NCT04424875
- Testing
- 3 mg melatonin
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Fayoum University
Impact Molar
Clinical and Radiographic Evaluation of Local Application of Melatonin on Postoperative Outcomes After Surgical Removal of Impacted Mandibular Third Molar
Clinical and Radiographic Evaluation of Local Application of Melatonin on Postoperative Outcomes after Surgical Removal of Impacted Mandibular Third Molar: A Randomized Controlled Study
- Trial name
- NCT07374536
- Testing
- Control, Melatonin gel
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University