Clinical trials: Third Molar Extraction
Pain
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940
The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth.
- Trial name
- NCT00659490
- Testing
- AZD1940, Naproxen
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Impacted Third Molar Tooth, Adverse Reaction to Other Local Anesthetics
Lower Third Molar Removal With 2% and 4% Articaine
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars.
- Trial name
- NCT02457325
- Testing
- Surgery with 2%Articaine first, then Surgery with 4% Articaine, Surgery with 4%Articaine first, then Surgery with 2% Articaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Third Molar Extraction
Analgesic Effect of Peripheral Dexmedetomidine
Dexmedetomidine is an alpha 2-adrenoreceptor agonist, which provides sedation, analgesia and anxiolysis in clinical practice (Cortinez et al., 2004,Hall et al., 2000).
- Trial name
- NCT00971178
- Testing
- local dexmedetomidine, Peripheral normal saline, IV dexmedetomidine
- Volunteers
- 105 people
- Sponsor
- The University of Hong Kong
Pain
Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain
This study will compare the pain relieving effect of a single-dose of a novel ibuprofen formulation to placebo and two formulations of standard ibuprofen in the treatment of post-surgical dental pain following "wisdom" tooth…
- Trial name
- NCT01098747
- Testing
- Novel Ibuprofen, Standard Ibuprofen
- Volunteers
- 335 people
- Sponsor
- Pfizer
Arnica, Third Molar Extraction
Efficacy of Arnica Montana in Reducing Postoperative Edema and Pain
This study is a prospective, randomized, double-blinded, controlled, clinical trial that evaluates the efficacy of using high potency homeopathic Arnica montana (SinEcch™) during the perioperative period for decreasing swelling…
- Trial name
- NCT03944629
- Testing
- SinEcch
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Tufts University
Dental Pain
Study of Long-Acting Acetaminophen in Postoperative Dental Pain
The purpose of the study is to evaluate the efficacy and safety of acetaminophen ER 1500 mg (two 750 mg tablets) over 10 to 12 hours in the dental pain model following third molar extraction(s) and to evaluate the…
- Trial name
- NCT01960114
- Testing
- Acetaminophen ER
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Post-operative Pain
Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study
The objective is to assess the efficacy and tolerability of a combination of 400 mg ibuprofen plus 1000 mg acetaminophen, 200 mg ibuprofen plus 500 mg acetaminophen compared with Nurofen Plus® and Panadeine® Extra.
- Trial name
- NCT01229449
- Testing
- Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®
- Where
- United States
- Volunteers
- 678 people
- Sponsor
- Reckitt Benckiser LLC
Tooth Extractions
A Randomized, Self Controlled Clinical Study of Hemostatic Efficacy of the HemCon Dental Dressing
The purpose of this study is to determine if the HemCon Dental Dressing is effective in stopping bleeding during dental surgeries.
- Trial name
- NCT00707486
- Testing
- Hemcon Dental Dressing, Gauze with Pressure and/or Gelfoam
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- HemCon Medical Technologies, Inc
Post Operative Pain
Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions
The most prevalent complaint after third molar extractions is pain. There have been many modalities and regimens developed to manage post-operative pain, such as modifications in surgical techniques, locally-applied medicaments…
- Trial name
- NCT05374499
- Testing
- Liposomal bupivacaine, 0.5% bupivacaine with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Postoperative Edema and Pain
Third Molar Extraction and Pulsed Electromagnetic FieldTherapy
This study is a prospective, randomized, double-blinded, controlled, clinical trial that evaluates the efficacy of using PEMF in the postoperative period in decreasing swelling and pain after extraction of impacted third molars.
- Trial name
- PEMF (NCT02376946)
- Testing
- ActiPatch(TM)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Tufts University
Pain
Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain
To evaluate efficacy and safety of additional dose of celecoxib, as compared to placebo, in patients with post lateral mandibular impacted third molar tooth extraction pain.
- Trial name
- NCT01062113
- Testing
- Celecoxib
- Where
- 22 sites in Japan
- Volunteers
- 255 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Dental Pain
Study of Naproxen Capsules to Treat Dental Pain
The purpose of the study is to determine whether Naproxen Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT01229228
- Testing
- Naproxen Test, Naprosyn
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Iroko Pharmaceuticals, LLC
Pain
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1386
The primary aim of this study is to investigate if AZD1386 can relieve the pain induced by the surgical removal of one lower wisdom-tooth.
- Trial name
- NCT00672646
- Testing
- AZD1386, Naproxen
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 75mg/ml in Treatment of Pain Following Dental Surgery
The present study is aimed at demonstrating the therapeutic equivalence of diclofenac HPBCD 75mg/1ml s.c. with the marketed reference product, Voltarol® 75mg/3ml i.m.
- Trial name
- NCT00943098
- Testing
- Diclofenac HPBCD s.c. 75mg/ml, Voltarol 75mg/3ml i.m.
- Where
- 3 sites in United Kingdom
- Volunteers
- 142 people
- Sponsor
- IBSA Institut Biochimique SA
Acute Pain
Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction
This study evaluated a new drug fixed-dose combination tablet (FDC) called tramadol/diclofenac at two different strengths (fixed doses of 25 milligrams [mg] of tramadol and of diclofenac or of 50 mg each).
- Trial name
- NCT03714672
- Testing
- Tramadol/Diclofenac 50/50, Tramadol/Diclofenac 25/25, Tramadol 50
- Where
- 8 sites in Mexico
- Volunteers
- 1,151 people
- Sponsor
- Grünenthal GmbH
Dental Crowding
Nicotine as an Adjuvant Analgesic for Third Molar Surgery
Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment.
- Trial name
- NCT00385216
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Pain
Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction
The purpose of this study was to evaluate analgesic efficacy and safety of hydrocodone/acetaminophen compared to placebo in moderate to severe pain following molar extraction.
- Trial name
- NCT00935311
- Testing
- ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release
- Where
- 3 sites in United States
- Volunteers
- 122 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Liposomal Bupivacaine
Exparel Versus Bupivacaine in Post-operative Pain Control
This is a prospective, randomized study to evaluate anaesthetic parameters, postoperative analgesia and oral analgesic consumption comparing exparel (liposomal bupivacaine) vs. standard bupivacaine
- Trial name
- NCT06547255
- Testing
- Bupivacaine liposome injectable suspension
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Pain, Post-Operative Pain
Ibuprofen Extended-Release Dental Pain Study
The purpose of this study is to evaluate the efficacy and safety of multiple doses of Ibuprofen 600 mg Extended-Release Tablets in a study of dental pain following extraction of third molar teeth.
- Conditions
- Pain, Post-Operative Pain, Third Molar Extraction
- Trial name
- NCT00707057
- Testing
- Ibuprofen 600 mg Extended-Release Tablets
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- SCOLR Pharma, Inc.
Dental Pain
Study of Diclofenac Capsules to Treat Dental Pain
The purpose of this study is to determine whether Diclofenac Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00985439
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib 400 mg
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Iroko Pharmaceuticals, LLC