Clinical trials: Thoracic Aneurysm
Coronary Artery Disease, Aortic Aneurysm
Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique
This is a prospective, controlled observational trial of patients undergoing clinically indicated cardiothoracic computed tomography (CT), including pulmonary or aortic angiography and coronary CT angiography (CCTA).
- Conditions
- Coronary Artery Disease, Aortic Aneurysm, Pulmonary Embolism
- Trial name
- CTDOSE (NCT01272453)
- Where
- 9 sites in United States, Saudi Arabia
- Volunteers
- 2,640 people
- Sponsor
- Gilbert L. Raff, MD
Thoracoabdominal Aortic Aneurysm, Ruptured Thoracic Aneurysm
Endovascular Aortic Repair of Free and Contained Ruptured Thoraco-Abdominal Aortic Aneurysm
Ruptured thoracoabdominal aortic aneurysm (TAAA) represents an emergency medical challenge that needs to be treated promptly. Over the past years different endovascular techniques have emerged such as fenestrated or branched…
- Conditions
- Thoracoabdominal Aortic Aneurysm, Ruptured Thoracic Aneurysm, Ruptured Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Ruptured
- Trial name
- REVAR-TAAA (NCT05956873)
- Testing
- REVAR
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
Thoracic Aortic Aneurysm
Transthoracic Ultrasound Evaluation of Thoracic Aortic Aneurysms
The Diagnosis of a thoracic Aortic Aneruysms usually made when imaging an abdominal aortic aneurysm which has reached threshold or as an incidental finding during a chest scan by computed tomography (CT) or magnetic resonance…
- Trial name
- NCT05137366
- Testing
- Transthoracic ultrasound scan
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Abdominal Aortic Aneurysm, Coronary Heart Disease NOS
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER Study
Study of heterogeneity in associations between social deprivation and the initial presentation of 12 cardiovascular diseases.
- Conditions
- Abdominal Aortic Aneurysm, Coronary Heart Disease NOS, Unheralded Corronary Death, Intracerebral Haemorrhage
- Trial name
- IP4 (NCT01937065)
- Testing
- No treatment
- Where
- United Kingdom
- Volunteers
- 1,937,360 people, healthy volunteers welcome
- Sponsor
- University College, London
Aortic Valve Regurgitation, Aortic Root Aneurysm
Clinical Evaluation of the Free Margin Cusp Sizer (CALIBRATE)
The objective of this study is to investigate safety and performance of the Free Margin Cusp sizer. The device will be used during aortic valve repair and sparing procedures as a caliper to measure the aortic valve free margin…
- Trial name
- CALIBRATE (NCT04797572)
- Testing
- Free Margin Cusp Sizer
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Marfan Syndrome
Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome
The purpose of this study is to evaluate if losartan limits aortic dilatation in patients with Marfan syndrome.
- Trial name
- MARFANSARTAN (NCT00763893)
- Testing
- Losartan
- Where
- France
- Volunteers
- 303 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aortic Aneurysm, Aortic Dissection
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
The Montalcino Aortic Consortium (MAC) will provide the infrastructure to assemble large cohorts of patients with mutations in known heritable thoracic aortic disease (H-TAD) genes, define the phenotype associated with these…
- Conditions
- Aortic Aneurysm, Aortic Dissection, Aortic Diseases
- Trial name
- MAC:H-TAD (NCT04005976)
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Thoracic Aortic Aneurysm
Valor II: The Valiant Thoracic Stent Graft System Clinical Study
This study was designed to study safety and effectiveness of the Valiant Thoracic Stent Graft to treat thoracic aortic aneurysms.
- Trial name
- NCT00413231
- Testing
- Valiant Thoracic Stent Graft System
- Where
- 26 sites in United States
- Volunteers
- 160 people
- Sponsor
- Medtronic Cardiovascular
Aortic Root Aneurysm, Aortic Root Dissection
Aortic Valve Sparing Root Replacement Versus Bentall
This study was designed to evaluate the hypothesis that the operative and midterm results of valve-sparing aortic root replacement are equivalent to those of the Bentall.
- Trial name
- NCT03604913
- Testing
- Aortic valve sparing operation, Bentall operation
- Where
- Egypt
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type A Aortic Dissection, Ascending Aortic Dissection
Outcomes of Aortic Dissection Repair
Type A aortic dissection (TAAD) is a potentially life-threatening pathology associated with significant risk of mortality and morbidity.
- Conditions
- Type A Aortic Dissection, Ascending Aortic Dissection, Aortic Diseases, Aortic Arch
- Trial name
- STAAD (NCT05927090)
- Testing
- Conservative Root- Sparing Aortic Valve Resuspension with or without Hemiarch Repair, Extensive Ascending Aorta Replacement (AAR) with Aortic Root Replacement (ARR), Extensive Ascending Aorta Replacement (AAR) with Total Arch Replacement (TARP)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Cardiologique du Nord
Aortic Arch Aneurysm
Simulation of Stent-graft Deployment in Aortic Arch Aneurysms
Total endovascular repair of the aortic arch represents a promising option for patients ineligible to open surgery. Custom-made design of stent-grafts (SG), such as the Terumo Aortic® RelayBranch device (DB), requires complex…
- Trial name
- NCT04244188
- Testing
- Collection of datas
- Where
- 2 sites in France, Netherlands
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
Assessment of Risk in Thoracic Aortopathy Using 18F-Sodium Fluoride
Patients with bicuspid aortic valve-related aortopathy are at increased risk of aortic dilatation, dissection and rupture. Currently, risk stratification is largely based on aortic diameter measurements, with those deemed high…
- Conditions
- Bicuspid Aortic Valve, Thoracic Aortic Aneurysm, Aortic Dissection
- Trial name
- AoRTAS (NCT04083118)
- Testing
- clinical evaluation, blood markers, pulse wave analysis, 18F sodium fluoride PET/CT and PET/MRI, Repeat 18F sodium fluoride PET/MRI
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aortic Aneurysm, Thoracic
Detection of Hypoxia in Human Thoracic Aorta Using Pimonidazole Hydrochloride
This is a prospective study designed to determine the safety and value of Hypoxyprobe-1 (pimonidazole hydrochloride (-HCl)) to detect levels of tissue hypoxia in patients presenting with ascending aortic aneurysm.
- Trial name
- NCT03410420
- Testing
- Pimonidazole hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Gleason
Aortic Aneurysm
ATLANTIS:Extensive Type A Dissections and Thoracic/ Thoraco-Abdominal Aneurysms Repair With LupiAe Hybrid TechNique
To prospectively evaluate the safety and efficacy of the LUPIAE hybrid technique for the treatment of thoracic or thoraco-abdominal aortic aneurysms thoracic aortic type A dissections 2.
- Trial name
- ATLANTIS (NCT01107366)
- Testing
- lupiae technique
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Thoracic Aortic Aneurysm
Effects of Exercise on Thoracic Aneurysms
Thoracic aneurysm incidence is estimated to 4.5 cases per 100 000. The manifestation as well as natural history of thoracic aneurysm depend on many factors such as its localisation, its diameter, presence of collagen disease and…
- Trial name
- EXTRA (NCT04197648)
- Testing
- Exercise group
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Thoracic Aortic Aneurysm
ENTRUST - TAArget® Thoracic Stent Graft Clinical Trial
Evaluate the safety and effectiveness of endovascular repair with the LeMaitre TAArget thoracic stent graft as an alternative to open surgical repair.
- Trial name
- NCT01033214
- Testing
- Endovascular repair of TAA in the descending Thoracic Aorta
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke Vascular, Inc.
Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic
Endovascular Treatment of TAAA and Aortic Arch Aneurysms Using Fenestrated and Branched Stent Grafts
Prospective, nonrandomized, single-center, two-arm study to assess the feasibility and safety and to evaluate clinical outcomes of endovascular repair of complex aortic aneurysms (thoracoabdominal aortic aneurysms and aortic arch…
- Conditions
- Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Thoracic, Aortic Dissection, Thoracoabdominal
- Trial name
- NCT02323581
- Testing
- Endovascular treatment of Thoracoabdominal Aortic Aneurysm, Endovascular treatment of Aortic Arch Aneurysms
- Where
- 2 sites in United States
- Volunteers
- 520 people
- Sponsor
- Darren Schneider, M.D.
Aortic Aneurysm, Postoperative Nausea and Vomiting
AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair
The aim of this randomized trial is to assess the efficacy of analgesia using either thoracic epidural or intravenous infusions for open lumbar infrarenal aortic aneurys repair and compare Numerical Rating Scale (NRS) with…
- Conditions
- Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain, Haemodynamic Stability
- Trial name
- AoA-AAA (NCT06609993)
- Testing
- intravenous rescue opioid analgesia using fentanyl, intravenous rescue atropine administration, intravenous rescue urapidil administration
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Michał Stasiowski
Genetic Predisposition, Paraganglioma
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Given the expansion of indications for genetic testing and our understanding of conditions for which the results change medical management, it is imperative to consider novel ways to deliver care beyond the traditional genetic…
- Conditions
- Genetic Predisposition, Paraganglioma, Pheochromocytoma, ALS
- Trial name
- NCT06377033
- Testing
- Behavioral nudge
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania