Clinical trials: Thoracic Aortic Diseases
Aortic Arch Aneurysm
Homemade Fenestrated Physician-modified Stent-grafts for Arch Aortic Degenerative Aneurysm
The aim was to evaluate early and medium-term outcomes of single and double fenestrated physician-modified endovascular grafts (PMEGs) for endovascular aortic arch degenerative aneursym repair.
- Trial name
- NCT04809896
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation
ECG and CXR for Predicting Cardiovascular Diseases
This retrospective multicenter cohort study aims to develop and validate an artificial intelligence model integrating electrocardiography (ECG) and chest radiography (CXR) to predict future progression of regurgitant valvular…
- Conditions
- Valvular Heart Diseases, Valvular Heart Disease Stenosis and Regurgitation, Regurgitation, Aortic Valve, Regurgitation, Mitral
- Trial name
- NCT07573852
- Where
- China
- Volunteers
- 116,380 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Aortic Dissection
Zenith® Dissection Endovascular System in the Treatment of Patients With Aortic Dissections
The Zenith® Dissection extended study is to collect confirmatory safety and effectiveness data on the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT02464943
- Testing
- Endovascular Treatment (Zenith)
- Where
- 3 sites in United States
- Sponsor
- Cook Research Incorporated
Dissection of Thoracic Aorta
Incidence and Risk Factors of Acute Kidney Injury After Thoracic Aortic Surgery Due to Dissection
Acute kidney injury (AKI) is one of the most frequently encountered and prognostically significant complications after cardiovascular surgery.
- Trial name
- NCT02190487
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Trauma Chest
Transesophageal Echocardiography To Diagnose Blunt Traumatic Aortic Injury Traumatic Aortic Injury
To determine test performance of transesophageal echocardiography performed by emergency physician ultrasound for the identification of blunt traumatic aortic injury in chest trauma.
- Trial name
- NCT05226858
- Testing
- Transesophageal echocardiography (TEE)
- Where
- 6 sites in Malaysia
- Volunteers
- 56 people
- Sponsor
- Hospital Raja Permaisuri Bainun
Pneumonia, Lung Cancer
On Dose Efficiency of Modern CT-scanners in Chest Scans
CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases.
- Conditions
- Pneumonia, Lung Cancer, Pulmonary Embolism, Pulmonary Disease
- Trial name
- NCT04996693
- Testing
- Imaging on Scanner with Spectral Imaging Capabilities, CT Scan using an Energy-Integrating Detector CT (128 slice MDCT), CT Scan using an Energy-Integrating Detector CT (20-slice MDCT)
- Where
- Germany
- Volunteers
- 958 people
- Sponsor
- University Hospital Augsburg
Thoracic Aorta Dilatation, Marfan Syndrome
Thoracic Aortic Dilatation Syndromes
Aortic dilatation syndromes are comprised by a group of different syndromes, of which Marfan syndrome is the best described. Many of the aorta dilatation associated syndromes are heritable connective tissue disorders but some…
- Trial name
- NCT02111668
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Bicuspid Aortic Valve, Thoracic Aortic Aneurysm
The Effect of Losartan in Bicuspid Aortic Valve Patients
The specific aims of this study are to: Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm.
- Trial name
- NCT01390181
- Testing
- Cozaar
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Michigan
Thoracic Aortic Aneurysms
Post-Approval Clinical Study of the Talent Thoracic Stent Graft to Treat Thoracic Aortic Aneurysms (THRIVE)
The purpose of this study is to evaluate the long-term safety and effectiveness of the Talent Thoracic Stent Graft System for treatment of descending thoracic aneurysms (DTA)following U.S. market approval.
- Trial name
- THRIVE (NCT00805948)
- Testing
- Talent Thoracic Stent Graft System
- Where
- 26 sites in United States
- Volunteers
- 349 people
- Sponsor
- Medtronic Cardiovascular
Aortic Aneurysm, Thoracic
Minimally Invasive Aortic Root and Aorta surGery rEgistry
Minimally invasive aortic valve (AV) surgery has become widely accepted alternative to standard sternotomy. Despite possible reduction in morbidity, this approach is not routinely performed for aortic surgery.
- Trial name
- MIRAGE (NCT04814238)
- Testing
- Aortic Root Surgery
- Where
- Poland
- Volunteers
- 2,000 people
- Sponsor
- Nicolaus Copernicus University
Aortic Aneurysm, Thoracic
The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized CardioLink-3 Trial
The ACE trial is a multicentre, randomized controlled trial comparing axillary vs. innominate artery cannulation for established antegrade cerebral perfusion in patients having aortic surgery (thoracic and aortic arch) requiring…
- Trial name
- NCT02554032
- Testing
- Axillary artery cannulation, Innominate artery cannulation
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm
Terumo Aortic Global Endovascular Registry
Multi-arm, multi-center, open label, prospective observational registry designed to obtain safety and performance data on the use of CE marked and custom Terumo Aortic endovascular grafts.
- Conditions
- Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
- Trial name
- TiGER (NCT04246463)
- Testing
- Thoracic, Abdominal, Custom Device
- Where
- 58 sites in United States, Belgium and 8 more
- Volunteers
- 1,000 people
- Sponsor
- Vascutek Ltd.
Aortic Aneurysm, Thoracic, Aortic Aneurysm, Abdominal
Development of Ultra-Low Dose CT Based Screening for Aortic Aneurysms
The primary objective of this research project is development and validation of a new, non-contrast gated aortic (NCGA) computer tomography scan algorithm for screening of aortic aneurysm in the chest and abdomen in at risk…
- Trial name
- NCT03479164
- Testing
- Ultra Low-Dose CT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Aortic Aneurysm, Thoracic
Feasibility Study for GORE® TAG® Thoracic Branch Endoprosthesis to Treat Proximal Descending Thoracic Aortic Aneurysms
The purpose of this study is to assess the feasibility of the use of the GORE® TAG® Thoracic Branch Endoprosthesis to treat aneurysms involving the proximal Descending Thoracic Aorta (DTA)
- Trial name
- NCT02021812
- Testing
- GORE® TAG® Thoracic Branch Endoprosthesis
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- W.L.Gore & Associates
Thoracic Aortic Aneurysm
Genes Modulating the Severity of Aortic Aneurysms (MSF1-TGFBR2)
This project concerns a population at risk of sudden death by dissection of the thoracic aorta. Its interest is to make it possible to recognize the genes that protect or worsen the evolution of aneurysms, to better understand…
- Trial name
- MSF1-TGFBR2 (NCT05146375)
- Testing
- TGFBR2
- Where
- France
- Volunteers
- 17 people
- Sponsor
- French Cardiology Society
Cardiac Arrythmias, Unstable Angina
CardioSenseSystem Compared Study Regarding Efficacy and Safety in the Monitoring of ECG
This is a prospective, controlled, comparative clinical trial of a new ECG monitoring system CardioSenseSystem prior CE marking.
- Conditions
- Cardiac Arrythmias, Unstable Angina, Heart Valve Disorders, Disorder of Aorta
- Trial name
- NCT03610529
- Testing
- CardioSenseSystem, Philips Intellivue
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Novosense AB
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Aortic Dissection
Zenith® Dissection Clinical Trial
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT01568320
- Testing
- Endovascular Treatment (Zenith)
- Where
- 24 sites in United States, Japan
- Volunteers
- 73 people
- Sponsor
- Cook Research Incorporated
Aneurysm, Dissecting, Aortic Aneurysm, Thoracic
To Evaluate the Safety and Efficacy for GORE TAG Thoracic Endoprosthesis in the Treatment of Thoracic Aortic Disease
PURPOSE OF RESEARCH: Endovascular stent-graft repair of aortic pathologies is a minimally-invasive alternative to open surgery that may decrease morbidity and mortality, particularly in high risk patients.
- Trial name
- NCT00757003
- Testing
- Endovascular Stent-graft repair of descending thoracic aorta
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Aortic Rupture
In Vivo Evaluation of Growth and Risk of Rupture of Dilated Ascending Aorta Using 4D Cardiac Magnetic Resonance
Ascending aorta aneurysmal disease is common and can be complicated by dissection or rupture. There is substantial variation in individual aneurysm progression: established risk factors for an accelerated aneurysm growth rate…
- Trial name
- NCT03172390
- Testing
- 4D Cardiac Magnetic Resonance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne