Clinical trials: Thoracic Injuries
Rib Fractures, Rib Fracture Multiple
Prospective Study of Video-assisted Rib Planting in Chest Wall Stabilization
The purpose of this study is to compare the advantages and disadvantages of video-assisted rib planting and traditional internal fixation of rib fractures in chest wall stabilization.
- Trial name
- NCT05340517
- Testing
- video-assisted rib planting
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Weigang Zhao
Lung Injury, Extravascular Lung Water
Lung Ultrasound Score and Pediatric Intensive Care Outcomes (LUS-PICO)
Bedside lung ultrasonography helps to obtain reliable clinical information about lung aeration, that has been categorized by means of the so-called lung ultrasound score (LUS).
- Conditions
- Lung Injury, Extravascular Lung Water, Pulmonary Edema, Acute Respiratory Distress Syndrome
- Trial name
- LUS-PICO (NCT04660448)
- Testing
- Bedside lung ultrasound examination
- Where
- Spain
- Volunteers
- 650 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Muscular Diseases
The Role of Ischaemia-reperfusion Injury in the Pathogenesis of Muscle Wasting After Thoracic Aortic Surgery
Single-centre observational study over one year investigating the mechanisms of muscle homeostasis in patients with acute skeletal muscle atrophy following major aortic surgery
- Trial name
- RIMMAS (NCT03354767)
- Testing
- Aortic and aortic valve surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chest Trauma, Rib Fractures
Acupuncture for Blunt Chest Trauma
Introduction: Chest blunt trauma accounts in up to 65% of polytrauma patients. In patients with 0-2 rib fracture, the treatment is relatively limited to oral pain killer and breathing exercise.
- Trial name
- NCT04318496
- Testing
- Press Tack Acupuncture
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- China Medical University Hospital
Thoracic Injuries
Far Forward Battlefield Telemedicine: Evaluation of Handheld Ultrasound
The goal of this study is to improve survival of battlefield trauma through ultrasound telemedicine and remotely guided therapeutics.
- Trial name
- NCT00615979
- Testing
- Miniature echo machine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Neonatal Resuscitation, Apnea Neonatal
Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates
Many extremely premature infants require immediate help with breathing after birth. Positive pressure ventilation (PPV) using a device called a T-piece resuscitator is a common method.
- Trial name
- MVP (NCT06849596)
- Testing
- Ventilator derived positive pressure ventilation - V-PPV, T-piece resuscitator (TPR)
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 780 people
- Sponsor
- Michelle Baczynski
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Wounds and Injuries, Rib Fractures
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma.
- Trial name
- NCT02432456
- Testing
- Ketamine, Intercostal Nerve Block, Acetaminophen
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Medical College of Wisconsin
Chest Trauma
Erector Spinae Plane Block Versus Thoracic Epidural Block for Chest Trauma
Rib fractures are very common as a consequence of blunt chest trauma which is associated with severe pain, morbidity and mortality.
- Trial name
- NCT03797079
- Testing
- ESP block, TEA, Catheter insertion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sameh Fathy
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Abdominal Surgery, Thoracic Surgery
Collecting Interval Timed Incisional Epidermal and Dermal Tissue Samples During Surgical Procedures to Profile Temporal Response of Tissue After Noxious Stimuli
Background: Opioids are a class of drug that are often used to manage pain after a person has surgery. Because of the current opioid crisis, researchers want to improve ways to manage pain after surgery with fewer side effects.
- Conditions
- Abdominal Surgery, Thoracic Surgery, Urological Surgery
- Trial name
- NCT04224870
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Rib Fractures, Rib Fracture Multiple
Ketamine vs Lidocaine in Traumatic Rib Fractures
Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical…
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib Trauma
- Trial name
- NCT04781673
- Testing
- Ketamine, Lidocaine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Brittany Hoyte
Rib Fractures
RibFix Advantage™ Post-Market Follow-Up
To confirm safety, performance, and clinical benefits for the use of RibFix Advantage™ in the fixation, stabilization, and fusion of rib fractures and osteotomies of normal and osteoporotic bone
- Trial name
- ZB-PIONEER (NCT05179005)
- Testing
- RibFix Advantage
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Zimmer Biomet
Spinal Cord Injuries
Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients
The global prevalence of spinal cord injury is estimated between 236 to 4187/Million. A spontaneous recovery of the sense-motoric function is decreasing with the time after injury and is only seen sporadically after 1 to 2 years.
- Trial name
- NCT03399968
- Testing
- ESWT
- Where
- 2 sites in Austria
- Volunteers
- 25 people
- Sponsor
- AUVA Trauma Center Meidling
Trauma Chest, Mechanical Ventilation
Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study
This is a single-center, prospective, physiological study. The study will enroll the traumatic lung injury patient who has at least 2 rib fractures requiring mechanical ventilation being on partially assisted breathing mode and…
- Trial name
- VICTORY (NCT06196125)
- Testing
- Four body positions
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
Pain Management, Thoracic Trauma
Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine
This study is a multicenter clinical trial conducted in Vinnytsia, Rivne, and Lviv, Ukraine, focusing on the management of acute pain following thoracic injuries sustained during combat.
- Conditions
- Pain Management, Thoracic Trauma, Pulmonary Function, Quality of Life
- Trial name
- CMS-APT-UA (NCT07380789)
- Testing
- Cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Lviv National Medical University
Cardiovascular Disease, Surgical Site Infection
Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Cardiovascular Disease, Surgical Site Infection, Superficial Sternal Wound Infection, Mediastinitis
- Trial name
- NCT07507409
- Testing
- Knotless Barbed Sutures, Mesh-based Topical Skin Adhesive
- Volunteers
- 401 people
- Sponsor
- Unity Health Toronto
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate.
- Trial name
- NCT06313515
- Testing
- Transcutaneous Spinal Cord Stimulation, Arm-crank bike exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Thoracic Anesthesia, One Lung Ventillation (OLV)
Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)
This prospective single-group cohort study aims to investigate the association between the One-Lung Ventilation (OLV) technique and myocardial injury, as measured by postoperative Troponin T and Troponin I levels, in patients…
- Trial name
- OLVTIS (NCT07302243)
- Where
- Indonesia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitas Jenderal Soedirman
Lung Cancer, Lung Metastases
Study to Evaluate the Efficacy and Safety of Nintedanib (BIBF 1120) + Prednisone Taper in Patients With Radiation Pneumonitis
The purpose of this study is to find out what effects, good and/or bad, the drug nintedanib in combination with steroids, has on the lungs. Furthermore, such treatments' side effects will be studied together with quality of life.
- Trial name
- NCT02496585
- Testing
- Nintedanib, Prednisone
- Where
- 12 sites in United States
- Volunteers
- 34 people
- Sponsor
- Memorial Sloan Kettering Cancer Center