Clinical trials: Thoracic Trauma
Osteoporosis, Interstitial Lung Disease
Opportunistic Screening for Osteoporotic Vertebral Fractures in Patients With Diffuse Interstitial Lung Disease
It is well known that some chronic respiratory pathologies such as asthma or chronic obstructive pulmonary disease (COPD) are associated with an increased risk of osteoporosis, due to the pathology itself and the therapies…
- Conditions
- Osteoporosis, Interstitial Lung Disease, Vertebral Fracture
- Trial name
- NCT05714787
- Testing
- Chest CT Scan examination
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
NSCLC
Echocardiography for RILI Prediction
Severe radiation-induced lung injury (RILI) occurs in approximately 20% of the lung cancer patients, who are treated with curative chemoradiation.
- Trial name
- NCT02501707
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht Radiation Oncology
Blunt Injury of Thorax, Multiple Rib Fractures, Involving Three Ribs
Low Dose Ketamine for Blunt Thoracic Trauma
The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures.
- Trial name
- NCT06236113
- Testing
- Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Memorial Health Care
Premature Birth, Obstructive Lung Disease
Pulmonary Outcomes of Bronchopulmonary Dysplasia in Young Adulthood
Preterm birth alters the normal sequence of lung development with lasting respiratory consequences. It is still unclear whether observed respiratory morbidities in preterm born individuals reflect sequelae from a non-progressive…
- Conditions
- Premature Birth, Obstructive Lung Disease, Bronchopulmonary Dysplasia
- Trial name
- NCT02820818
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Blunt Thoracic Injury, Lung Ultrasound Score
High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients
This prospective randomized controlled study was conducted in the emergency intensive care units (EICU) of the second affiliated hospital Zhejiang university school of medicine, a large tertiary university hospital in HangZhou…
- Trial name
- NCT03430258
- Testing
- high-flow nasal cannula, Conventional oxygen therapy
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Trauma Chest, Mechanical Ventilation
Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study
This is a single-center, prospective, physiological study. The study will enroll the traumatic lung injury patient who has at least 2 rib fractures requiring mechanical ventilation being on partially assisted breathing mode and…
- Trial name
- VICTORY (NCT06196125)
- Testing
- Four body positions
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Unity Health Toronto
ARDS, COVID-19
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS)…
- Conditions
- ARDS, COVID-19, Mechanical Ventilation Pressure High, Ventilator-Induced Lung Injury
- Trial name
- NCT06093958
- Testing
- Manual loading of the chest wall
- Where
- United States
- Sponsor
- HealthPartners Institute
Lung Cancer, Radiation Toxicity
Flaxseed Supplement in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Undergoing Chemotherapy and Radiation Therapy
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Flaxseed may help protect normal cells from the side effects of radiation therapy.
- Trial name
- NCT00955942
- Testing
- flaxseed
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Rib Fractures
Analgesic Techniques for Rib Fractures
This study will be a 3-arm, parallel-group, randomized controlled trial comparing three analgesic techniques for rib fractures with a sample size of 24 patients (8 per group).
- Trial name
- NCT06519929
- Testing
- ESP block with catheter using ropivacaine (bolus followed by continuous infusion), Lidocaine bolus (1 mg/kg) and infusion starting at 1 mg/kg/h
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Flail Chest
MatrixRIB Implants for Surgical Stabilization of Flail Chest Injuries: A Registry
The purpose of this observational study is to document the treatment of serial rib fractures with MatrixRIB implants in a registry.
- Trial name
- MatrixRIB (NCT00810251)
- Testing
- MatrixRIB (FDA Approval # K081623)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Legacy Biomechanics Laboratory
Rib Fracture
Ibuprofen Versus Dexketoprofen in Rib Fractures
The purpose of this study is to compare the pain-relieving effects of two different nonsteroidal anti-inflammatory drugs (NSAIDs), intravenous ibuprofen and intravenous dexketoprofen, in adults who present to the emergency…
- Trial name
- NCT07859631
- Testing
- Ibuprofen 800 mg, Dexketoprofen 50 mg
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara City Hospital Bilkent
Thoracic Injuries, Rib Fractures
Serratus Plane Block With Parenteral Opioid Analgesia Versus Patient Controlled Analgesia in Rib Fractures
In this multicentre randomised controlled trial, adult patients with isolated chest trauma and two or more unilateral rib fractures will be randomised to either serratus plane block and patient controlled analgesia or patient…
- Conditions
- Thoracic Injuries, Rib Fractures, Anaesthesia, Local, Levobupivacaine
- Trial name
- COPE (NCT03919916)
- Testing
- Serratus plane block, Patient controlled analgesia
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Rib Fractures, Pain, Acute
Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial
Blunt chest trauma is the second most common form of unintentional trauma in the US and is associated with significant morbidity and mortality. Thoracic injuries are the third most common cause of death in trauma patients.
- Trial name
- NCT05321121
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Irvine
Rib Fractures, Pain, Acute
A Retrospective Review of Rib Fracture Pain Management at a London Major Trauma Centre
Thoracic epidural analgesia (TEA) is widely considered to be the current gold standard treatment for rib fracture pain and is used in the Imperial invasive treatment pathway for rib fractures.
- Trial name
- NCT04863807
- Testing
- Regional Anaesthesia
- Where
- United Kingdom
- Volunteers
- 389 people
- Sponsor
- Imperial College Healthcare NHS Trust
Myocardial Injury, Lung Injury
Neurogenic Myocardial and Lung Injury in SAH Patients
Up to this day, little is known whether the extent of brain damage in patients with SAH correlates with the degree neurogenic myocardial injury and neurogenic lung injury.
- Conditions
- Myocardial Injury, Lung Injury, Subarachnoid Hemorrhage
- Trial name
- NCT05408988
- Testing
- hs-TnT (high-sensitive cardiac troponin T) plasma concentration, CK-MB (creatine kinase myocardial band) plasma concentration, CPK (creatine phosphokinase) plasma concentration
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
Endotracheal Intubation, Pediatric
Pediatric Intubation During Emergency Conditions
The effectiveness of endotracheal intubation in pre-hospital conditions is insufficient - especially in the context of pediatric patients.
- Conditions
- Endotracheal Intubation, Pediatric, Cardiac Arrest, Injuries
- Trial name
- NCT03602183
- Testing
- Macintosh laryngoscope, Miller laryngoscope, McGrath MAC EMS
- Where
- Poland
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Lazarski University
Small Cell Lung Cancer, Limited Stage, Stage III Non-small Cell Lung Cancer
Image-Guided Functional Lung Avoidance Thoracic Radiotherapy for Lung Cancer: A Single-Blind Randomized Trial
Thoracic radiotherapy (TRT) is a standard curative treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC) and limited stage small cell lung cancer (SCLC).
- Trial name
- NCT03077854
- Testing
- Functional Lung Avoidance Thoracic Radiotherapy, Standard Thoracic Radiotherapy
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan University Hospital
Rib Fracture, Rib Fracture Multiple
Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma
Thoracic trauma frequently involve rib fractures which can be very painful for 2-3 months. Unfortunately, pain is not simply a "symptom" of the injuries, but a significant cause of additional medical problems: pain causes people…
- Trial name
- NCT06069154
- Testing
- Cryoneurolysis, Local anesthetic peripheral nerve block
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Rib Fractures
Suzetrigine for Acute Pain Control in Patients With Multiple Rib Fractures
Rib fractures cause a significant amount of pain and are associated with an increased risk of lung infections, long hospitalization, and increased cost.
- Trial name
- NCT07145346
- Testing
- Suzetrigine (SUZ)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Irvine
Acute Lung Injury, Pulmonary Injury
Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury
This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death.
- Conditions
- Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
- Trial name
- ENDALI (NCT05316727)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh