Clinical trials: Thoracic Trauma
Small Cell Lung Cancer ( SCLC ), Brain Injury
Exploration of Whole-Brain Radiotherapy Combined With PD-1 Inhibitors on Brain Injury
The study aims to enroll the small cell lung cancer(SCLC) who meet the indications for prophylactic cranial irradiation (PCI): patients with limited-stage SCLC who have achieved complete or partial remission after first-line…
- Trial name
- NCT07905937
- Testing
- PD-1 Inhibitor + Chemotherapy+PCI, chemotherapy+PCI
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Guizhou Medical University
Pneumoconiosis
Evaluation of Pneumoconiosis High Risk Early Warning Models
Precaution of pneumoconiosis is more important than treatment. However, the current process can't early warn the high-risk dust exposed workers until they are diagnosed with pneumoconiosis.
- Trial name
- NCT04952675
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Lung Injury
Respiratory Variability and Postoperative Complications During Thoracic Lung Resection.
Postoperative respiratory complications (PRC) represent a major public health issue. Majority of PRCs occur once the patient leaves the post-interventional monitoring room.
- Trial name
- RESPIVARIA (NCT06133777)
- Testing
- Respiratory variability monitoring
- Where
- France
- Volunteers
- 60 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Radiation Induced Lung Injury (RILI)
Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation
The purpose of this work is to perform hyperpolarized (HP) 129Xe MRI in human subjects undergoing thoracic radiation therapy (RT), both before, during and following RT.
- Trial name
- RILI (NCT03431129)
- Testing
- Hyperpolarized gas and proton lung MRI
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- The Hospital for Sick Children
Pain, Postoperative, Cardiac Surgery
Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)
The main objective is to compare the effectiveness of LocoRegional Anesthesia (LRA) (bilateral transverse thoracic block or bilateral parasternal block) in addition to standard management compared to standard management alone…
- Trial name
- PABLOS (NCT05345639)
- Testing
- LRA Loco-regional anesthesia, Standardized post-operative analgesia protocol
- Where
- France
- Volunteers
- 254 people
- Sponsor
- University Hospital, Angers
Stroke, Silent Cerebral Infarction
Intervention With Cerebral Embolic Protection in TEVAR: Gaseous Protection
Vascular brain infarction (VBI) occurs in 67% of patients undergoing TEVAR. Overt stroke occurs in 13% of these patients and 88% of patients suffer from neurocognitive impairment.
- Conditions
- Stroke, Silent Cerebral Infarction, Neurocognitive Dysfunction, Vascular Brain Injury
- Trial name
- INTERCEPT:GP (NCT03886675)
- Testing
- CO2 flushing, Saline flushing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Rib Fractures, Rib Fracture Multiple
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death.
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
- Trial name
- UNPIN (NCT05865327)
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Rib Fractures
Continuous Intravenous Lidocaine Infusion Versus Placebo for Rib Fracture Analgesia
The current cornerstone of pain control for rib fractures is oral and intravenous opioids, especially in the form of patient-controlled analgesia (IV PCA), which are are associated with multiple adverse effects including…
- Trial name
- NCT04140396
- Testing
- Saline infusion, Lidocaine infusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Rib Fractures, Rib Trauma
Costal Fracture Assessment for Relief and Enhancement of Quality of Life
This study explores the impact of rib fractures on patient well-being and quality of life, aiming to identify effective interventions for pain relief and functional improvement.
- Trial name
- CARE (NCT06405841)
- Testing
- Survey, Pain management
- Where
- 4 sites in Italy
- Volunteers
- 950 people
- Sponsor
- Ospedali Riuniti Trieste
Rib Fractures
Sheffield Multiple Rib Fractures Study:
An observational study to derive clinically relevant and predictive rib fracture classification systems, based on retrospective and prospective cohorts, incorporating assessment of PROMs (Patient Reported Outcome Measures) and…
- Trial name
- SMuRFS (NCT02608541)
- Testing
- rib fracture fixation
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Abdominal Injuries, Thoracic Injuries
Robot-based Tele-echography II - A Comparative Study
The aim of this clinical trial is to evaluate the concordance of diagnosis of injuries in thoracoabdominal trauma using two different echographic methods.
- Conditions
- Abdominal Injuries, Thoracic Injuries, High Energy Trauma
- Trial name
- NCT00295438
- Testing
- Robot-Based Tele-Echography (TER), ultrasound method FAST
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Grenoble
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
Postoperative Pain, Postoperative Atelectasis
Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries
Pain management is important after coronary artery bypass graft (CABG) surgery. Intravenous morphine is the gold standard for pain relief, but its sedation, cough suppression and decreased bowel movements limit its use.
- Conditions
- Postoperative Pain, Postoperative Atelectasis, Analgesia
- Trial name
- NCT06267443
- Testing
- Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
Acute Traumatic Spinal Cord Injury
Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury
The main objective of the study is the evaluation of the safety and tolerability of FAB117-HC (a medicinal product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed with H2O2, HC016…
- Trial name
- SPINE (NCT02917291)
- Testing
- FAB117-HC, Control group
- Where
- 9 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Ferrer Internacional S.A.
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Aortic Dissection
Zenith® Dissection Clinical Trial
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT01568320
- Testing
- Endovascular Treatment (Zenith)
- Where
- 24 sites in United States, Japan
- Volunteers
- 73 people
- Sponsor
- Cook Research Incorporated
Pulmonary Fibrosis, Unspecified
68Ga-NOTA-PRGD2 PET/CT in Patients With Lung Injury and Pulmonary Fibrosis
This is an open-label positron emission tomography/computed tomography (PET/CT) study to investigate the diagnostic performance and evaluation efficacy of 68Ga-NOTA-PRGD2 in lung injury (LI) and pulmonary fibrosis (PF) patients.
- Trial name
- NCT02511197
- Testing
- 68Ga-NOTA-PRGD2, PET/CT
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
ARDS (Acute Respiratory Distress Syndrome), AI (Artificial Intelligence)
Exploration of Diagnosis and Treatment Strategies and Prognostic Prediction Models for Acute Respiratory Distress Syndrome Based on Radiographic Evaluations Assessed by Artificial Intelligence
By using multi-center chest CT data, an intelligent assessment model for the severity of ARDS was constructed. Based on CT quantitative features and clinical characteristics, a prediction model for short-term critical events…
- Trial name
- NCT07328997
- Testing
- CT scan
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
Intestines Cancer, Pulmonary Cancer
Main Postoperative Complications After COVID-19
To explore the relationship between SARS-CoV-2 infection in different time before operation and postoperative main complications (mortality, main pulmonary and cardiovascular complications) 30 days after operation; To determine…
- Conditions
- Intestines Cancer, Pulmonary Cancer, Liver Cancer, Trauma
- Trial name
- NCT05694949
- Volunteers
- 100,000 people
- Sponsor
- RenJi Hospital
Lung Injury, Remote Ischemic Preconditioning
Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery
During cardiac surgery with cardiopulmonary bypass , pulmonary dysfunction remains to be a problem complicating the postoperative course of the patients.Remote ischemic preconditioning(RIPC) with transient upper limb…
- Trial name
- NCT03016182
- Testing
- Remote Ischemic Preconditioning, Control
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuzhou Medical University