Clinical trials: Thoracic Trauma
Trauma Abdomen
Impact of Loco-regional Analgesia Following Placement of Erector Spinae Plane Catheter in Addition to Systemic Analgesia in Patients With Thoracic Trauma
The management of analgesia is the key issue in the management of a thoracic trauma patient to prevent respiratory complications.
- Trial name
- ERECTRAUTHO (NCT05288985)
- Testing
- Erector spinae plane catheter group in addition to Systemic Analgesia, Systemic Analgesia Only Group
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Abdominal Injury, Thoracic Diseases
A Post Market Study to Confirm the Safety and Performance of the Signia™ Stapling System.
The objectives of this prospective, two-arm, multicenter post-market study is to confirm safety and performance through the incidence of subjects reporting serious adverse device effects (ADEs) up to and including 30 days…
- Trial name
- NCT03515811
- Testing
- Signia™ Stapling System
- Where
- 11 sites in United States, Canada and 3 more
- Volunteers
- 136 people
- Sponsor
- Medtronic - MITG
Trauma, Flail Chest
Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma
The purpose of this prospective controlled study is to determine whether surgical management of unstable thoracic cage injuries and chest wall deformity in trauma reduces the need for and the time spent on ventilator compared to…
- Conditions
- Trauma, Flail Chest, Rib Fractures, Surgery
- Trial name
- NCT02132416
- Testing
- NSAID, Opioids, Thoracic Epidural anaesthesia
- Where
- 2 sites in Sweden
- Volunteers
- 92 people
- Sponsor
- Sahlgrenska University Hospital
Intercostal Nerve Injury
Evaluation of Intercostal Neuralgia in Patients With Chest Tube Insertion After Traumatic Rib Fracture
Traumatic rib fractures are common injuries following blunt chest trauma, often requiring chest tube insertion to manage complications such as pneumothorax or haemothorax.
- Trial name
- NCT07308587
- Testing
- Chest tube insertion
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Lung Cancer, Lung Metastases
Study to Evaluate the Efficacy and Safety of Nintedanib (BIBF 1120) + Prednisone Taper in Patients With Radiation Pneumonitis
The purpose of this study is to find out what effects, good and/or bad, the drug nintedanib in combination with steroids, has on the lungs. Furthermore, such treatments' side effects will be studied together with quality of life.
- Trial name
- NCT02496585
- Testing
- Nintedanib, Prednisone
- Where
- 12 sites in United States
- Volunteers
- 34 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Kidney Injury Following Open-Chest Cardiac Surgery
A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery
The goal of this clinical trial is to identify the optimal dose of RMC-035 for protection of long-term renal function in adult patients undergoing cardiac surgery who are at high risk of kidney injury.
- Trial name
- POINTER (NCT06475274)
- Testing
- RMC-035
- Where
- 19 sites in Canada, Czechia and 2 more
- Volunteers
- 170 people
- Sponsor
- Guard Therapeutics AB
Spinal Cord Injuries, Spinal Cord Diseases
Sub-study to Spinal Cord Stimulation to Restore Cough
Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00995215
- Testing
- Spinal Cord Stimulation, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- MetroHealth Medical Center
Lung Injury, Acute, Respiratory Distress Syndrome, Adult
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
The purpose of this study is to determine the effectiveness of etanercept in the treatment of patients with sub-acute lung injury following a bone marrow transplant.
- Conditions
- Lung Injury, Acute, Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
- Trial name
- NCT00141726
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center
Pneumothorax, Trauma
Suction Versus Water Seal for Initial Treatment of Traumatic Pneumothorax Trial
The goal of this clinical trial is to compare the effect of placing chest tubes to water seal versus suction initially, in patients with traumatic pneumothoraces, on overall chest tube duration.
- Trial name
- SEAL IT (NCT06688734)
- Testing
- Inital water seal, Initial suction
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Vanderbilt University Medical Center
Pneumothorax, Pulmonary Interstitial Emphysema
Surfactant Administration During Spontaneous Breathing
Spontaneous breathing supported by nasal continuous positive airway pressure (nCPAP) is thought to have some advantages compared with mechanical ventilation in premature infants.
- Conditions
- Pneumothorax, Pulmonary Interstitial Emphysema, Bronchopulmonary Dysplasia
- Trial name
- TAKE CARE (NCT01329432)
- Testing
- Take care, InSurE
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Thoracic Trauma
Feasibility of the Gamification of Incentive Spirometry in Trauma Patients
Gamification may be one solution that can increase the compliance in the use of devices like incentive spirometry.
- Trial name
- NCT06090279
- Testing
- OmniFlow Breathing Therapy BioFeeback System
- Sponsor
- Wake Forest University Health Sciences
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Spinal Cord Injury
A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries
This trial is a multi-center, open-label, dose-escalation study designed to evaluate the safety, tolerability and pharmacokinetics of Cethrin in two types of spinal cord injury patients: those with a complete cervical injury or a…
- Trial name
- NCT00500812
- Testing
- Cethrin
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Non-small Cell Lung Cancer, Older People
Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients
To observe the effect and toxicity of carbon ion radiotherapy on local advanced non-small cell lung cancer over 75 years old patients. Systemic therapy could be targeted therapy, chemotherapy or immunotherapy.
- Conditions
- Non-small Cell Lung Cancer, Older People, Carbon Ion Radiotherapy, Radiotherapy Side Effect
- Trial name
- NCT06311981
- Testing
- carbon ion radiotherapy, targeted therapy, single regimen chemotherapy in sequence with radiotherapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Jian Chen
Complex Regional Pain Syndromes
THORACIC MANIPULATION and COMPLEX REGIONAL PAIN SYNDROME
To compare the effect of combined thoracic manipulation (TM) and traditional physical therapy treatment (TPT) versus TPT treatment alone on pain severity at rest and functional disability in patients with type 1 complex regional…
- Trial name
- NCT04769128
- Testing
- Traditional physical therapy programe
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- South Valley University
Bronchopulmonary Dysplasia
Pragmatic Research on Diuretic Management in Early BPD Pilot
Babies who are born prematurely often develop a chronic lung disease called bronchopulmonary dysplasia (BPD). BPD puts babies at higher risk for problems with growth and development.
- Trial name
- PRIMED (NCT05898022)
- Testing
- Furosemide (plus potassium chloride)
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Infection, Alcohol Abuse
Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease.
- Conditions
- Infection, Alcohol Abuse, Drugs of Abuse, Lung Injury
- Trial name
- NCT02299921
- Testing
- Characterize alcohol and drug use
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as amifostine may protect normal cells from the side effects of chemotherapy and radiation…
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00003583
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Myocardial Injury, Lung Injury
Neurogenic Myocardial and Lung Injury in SAH Patients
Up to this day, little is known whether the extent of brain damage in patients with SAH correlates with the degree neurogenic myocardial injury and neurogenic lung injury.
- Conditions
- Myocardial Injury, Lung Injury, Subarachnoid Hemorrhage
- Trial name
- NCT05408988
- Testing
- hs-TnT (high-sensitive cardiac troponin T) plasma concentration, CK-MB (creatine kinase myocardial band) plasma concentration, CPK (creatine phosphokinase) plasma concentration
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
Hypotension, Kidney Injury
Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
The purpose of this study is to conduct a prospective, randomized, controlled trial comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients.
- Trial name
- NCT02135146
- Testing
- Plasmalyte 3ml/kg/hr group, Plasmalyte 6ml/kg/hr group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver