Clinical trials: Thoracic Trauma
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Patients Undergoing Cardiothoracic Surgery
Limiting IV Chloride to Reduce AKI After Cardiac Surgery
This primary aim of this study is to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery.
- Trial name
- LICRA (NCT02020538)
- Testing
- Low-chloride perioperative intravenous fluid strategy, High-chloride perioperative intravenous fluid strategy
- Where
- Australia
- Volunteers
- 1,298 people
- Sponsor
- Bayside Health
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Lung Cancer
Evaluation of Chronic Pain After Nerve Section During Thoracotomy
The purpose of this study is to investigate if controlled nerve section reduces chronic pain after thoracotomy.
- Trial name
- NCT00653367
- Testing
- Nerve section
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Stimulation to Restore Cough
The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Paralysis, Central Nervous System Diseases
- Trial name
- NCT00116337
- Testing
- Spinal Cord Stimulation to restore cough, Expiratory Muscle Stimulator
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MetroHealth Medical Center
Rib Fracture Multiple, Trauma Chest
Lidocaine Infusions for Rib Fractures
Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study.
- Conditions
- Rib Fracture Multiple, Trauma Chest, Pain, Acute
- Trial name
- Lidocare (NCT03571919)
- Testing
- Lidocaine infusion, Saline infusion
- Where
- United States
- Sponsor
- Stanford University
Pain, Acute, Rib Fractures
Mid-point to Pleura Transverse Process Block Versus Thoracic Intervertebral Foramen Block
The analgesic effect of continuous mid-point to pleura transverse process block compared to the analgesic effect of continuous thoracic intervertebral foramen block, in patients with multiple rib fractures.
- Conditions
- Pain, Acute, Rib Fractures, Polytrauma
- Trial name
- NCT05348330
- Testing
- Thoracic intervertebral foramen block, Mid-point to pleura transverse process block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Lung Contusion
Respiratory Function Monitoring of Mechanical Ventilation in Patients With Chest Blunt Injury
The goal of this observational study is to learn about EIT in observing the application of lung protective ventilation strategies in patients with pulmonary contusion, particularly the impact on pulmonary ventilation blood flow…
- Trial name
- NCT06386120
- Testing
- PEEP setting strategy
- Volunteers
- 80 people
- Sponsor
- Peking University People's Hospital
Cardiotoxicity, Thoracic Radiotherapy
Optimizing Radiation Dose and Utilizing Wearable Devices to Reduce Arrhythmia Risk in Patients Undergoing Thoracic Radiotherapy: A Prospective Cohort Study
This prospective observational cohort study aims to assess the risk of radiation-induced cardiotoxicity in patients undergoing thoracic radiotherapy by integrating real-time arrhythmia monitoring using wearable cardiac…
- Conditions
- Cardiotoxicity, Thoracic Radiotherapy, Wearable Electronic Devices, Thoracic Neoplasms
- Trial name
- NCT06897189
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Yonsei University
Breast Cancer, Lung Cancer (Non-Small Cell)
Cardiac MRI Biomarker Testing (GCC 1618)
This research study can help understand how cardiac changes may occur with radiation therapy to the heart based off measurements obtained through biomarkers and cardiac imaging.
- Conditions
- Breast Cancer, Lung Cancer (Non-Small Cell), Thoracic Cancer, Thymic Cancer
- Trial name
- NCT02688166
- Testing
- Complete Cardiac Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Maryland, Baltimore
Hypotension, Spinal Cord Injury
Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males
To address the effect of tadalafil (Cialis) on the cardiovascular system of men with complete spinal cord injury at T-6 and above. The hypothesis is that tadalafil will cause significant hypotension in people with tetraplegia.
- Trial name
- NCT01067391
- Testing
- tadalafil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Acute Hypoxemic Respiratory Failure, Diaphragm Injury
Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
This is a single-center proof-of-concept clinical trial designed to establish the feasibility of transvenous phrenic-nerve stimulation (PNS) to maintain diaphragm activation over the first 24 hours and for up to seven days of…
- Conditions
- Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
- Trial name
- STIMULUS (NCT05465083)
- Testing
- Lungpacer AeroPace Protect System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Spine Trauma (Thoracic and Lumbar)
3D Printing in Preoperative Planning in Thoracic and Lumbar Spine Trauma
Case series of 16 patients with lower lumbar or lower thoracic traumatic injuries treated with pedicle screw fixation. Patients were divided into two groups (n≈8 per group).
- Trial name
- NCT07727161
- Testing
- Spine stabilization using CT planning, Spine stabilization using 3D-printed model planning
- Where
- Czechia
- Volunteers
- 16 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Chest Trauma
Thorax Trauma Severity Score in Chest Trauma: A Study in Iraq
This prospective observational study aims to evaluate the predictive utility of the Thorax Trauma Severity Score (TTSS) in determining morbidity and mortality in patients presenting with chest trauma at a tertiary hospital in…
- Trial name
- TTSS-Iraq (NCT06744959)
- Where
- Iraq
- Volunteers
- 166 people
- Sponsor
- Al-Nahrain University
Lung Disease, Wrist Fracture
Tomosynthesis of Pathologies of the Chest and Skeletal Structures in Comparison to CT
The investigators propose tomosynthesis as a imaging method in between of x-ray and CT. The expected value of this project is the definition of proven indications for tomosynthesis, which allow replacing CT.
- Trial name
- NCT02464280
- Testing
- Tomosythesis scan of the lung or the wrist, CT scan of the lung or the wrist, conventional X-ray of the lung or the wrist
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Sever Chest Trauma, Mechanical Ventilation
Driving Pressure in Trauma
Traumatic chest injuries are responsible for significant morbidity and the cause of trauma-related death in 20%-25% of cases. Thoracic trauma can include multiple injuries, mainly osseous (ribs, sternal fractures, flail chest)…
- Trial name
- NCT03367442
- Testing
- no intervention
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Chest Trauma
Erector Spinae Plane Block Versus Thoracic Epidural Block for Chest Trauma
Rib fractures are very common as a consequence of blunt chest trauma which is associated with severe pain, morbidity and mortality.
- Trial name
- NCT03797079
- Testing
- ESP block, TEA, Catheter insertion
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sameh Fathy
Chest Wall Injury
Infuence of Kinesiotaping on Pulmonary Function Improvement in Multiple Rib Fracture
Elastic tapes, named "kinesiotapes" have a limited, but proven influence on pain reduction, improvement in muscular strength and joint function.
- Trial name
- NCT05753982
- Testing
- Kinesiotape placement
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Covid19, Lung Injury
Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19
COVID-19 is impacting on health systems in Brazil and worldwide. Reducing the risk of clinical deterioration and prolonged disease duration in hospitalized patients with COVID-19 may alleviate the burden caused by the pandemic.
- Trial name
- NCT04470297
- Testing
- Ramelteon 8mg
- Volunteers
- 100 people
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Depression, Anxiety
Monoamine Oxidase A PET/CT in Various MAO-A-Related Disease
To evaluate the potential usefulness of 18F-AIPF-1026 positron emission tomography/ computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-A-related disease patients.
- Conditions
- Depression, Anxiety, Heart Injuries
- Trial name
- NCT07685860
- Testing
- Diagnostic Test: 18F-AIPFA-1026
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University