Clinical trials: Thromboembolic Disease
Arterial Thromboembolism
A PMCF Study to Confirm the Performance and Safety of the LeMaitre® TufTex Single Lumen Embolectomy Catheter
A post market clinical study to confirm the performance and safety of the LeMaitre® TufTex Single Lumen Embolectomy Catheter on patients undergoing surgical treatment for the removal of arterial emboli and/or thrombi
- Trial name
- SLC (NCT05386277)
- Testing
- TufTex Single Lumen Embolectomy Catheter
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 112 people
- Sponsor
- LeMaitre Vascular
Healthy, Heart Valves
Assessment of a Diagnostic Medical Device for the INR (International Normalized Ratio) Measurement
The purpose of this study is to assess the measurement conformity of an in vitro diagnostic device measuring the INR (International harmonized Ratio).
- Conditions
- Healthy, Heart Valves, Arrhythmias, Cardiac, Thromboembolism
- Trial name
- HEMOPTICS2 (NCT02779400)
- Testing
- Self testing INR device
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Venous Thromboembolism
Predicting Bleeding Risk on Anticoagulant Therapy for Venous Thromboembolism
The main objective of the study is to develop or validate a clinical prediction rule for major bleeding in patients on oral anticoagulant therapy who have been safely anticoagulated without bleeding or venous thromboembolism…
- Trial name
- NCT00788736
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 2,537 people
- Sponsor
- Ottawa Hospital Research Institute
Prosthesis; Cardiac, Heart, Functional Disturbance as Result
Rivaroxaban in Mechanical Valves: RMV Study
Anticoagulant treatment reduces the incidence of death and cardioembolic events in patients with atrial fibrillation or prosthetic heart valve and the incidence of death and recurrences in patients with VTE.
- Trial name
- RMV (NCT02894307)
- Testing
- Rivaroxaban
- Sponsor
- Hospital Ana Nery
Blood Loss, Surgical
Observational Cohort Study of TachoSil (TC-018-IN)
The purpose of this study is to collect information, after exposure to TachoSil ®, of all thromboembolic events, immunological events and drug interactions leading to thromboembolic events or major bleeding.
- Trial name
- NCT00285623
- Testing
- Fibrinogen (human) + thrombin (human) (TachoSil)
- Where
- Denmark
- Volunteers
- 3,000 people
- Sponsor
- Nycomed
Venous Thromboembolism
Can Thrombin Generation Measurement Predict the Risk of Venous Thromboembolism in Acute Ill Patients
Can thrombin generation measurement predict the risk of venous thromboembolism in acute ill patients Traditional coagulation tests do not assess the whole coagulation system.
- Trial name
- NCT01744431
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- HaEmek Medical Center, Israel
Severe Trauma Patient, Venous Thromboembolism
Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients: a Multicenter Double Blind Randomised Controlled Trial
Venous thromboembolism is a frequent issue in severe trauma patients. Guidelines for venous thromboembolism prevention include the use of pharmacological thromboprophylaxis, mainly with low-molecular-weight heparin, and/or…
- Trial name
- HEPTRAUMA (NCT07506473)
- Testing
- Enoxaparin standard dose, Enoxaparin intermediate dose
- Where
- 17 sites in France
- Volunteers
- 540 people
- Sponsor
- University Hospital, Grenoble
AORTIC VALVE DISEASES, Thromboembolism
Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement
This study evaluates the long-term anticoagulation with oral factor Xa inhibitor versus vitamin K antagonist in patients receiving a mechanical aortic valve replacement.
- Trial name
- RENOVATE (NCT04258488)
- Testing
- Rivaroxaban Oral Tablet, Vitamin K antagonist(warfarin)
- Where
- 16 sites in South Korea
- Volunteers
- 1,300 people
- Sponsor
- Joon Bum Kim
Respiratory Distress Syndrome, Adult, Extracorporeal Membrane Oxygenation
PGE1 as Additive Anticoagulant in ECMO-Therapy
Bleeding complications and thromboembolic complications are frequent during extracorporeal membrane oxygenation (ECMO). Retrospective data suggest that platelet inhibition using prostaglandins, in this case PGE1, may reduce…
- Trial name
- ECMO_PGE1 (NCT02895373)
- Testing
- Alprostadil, 0.9% sodium chloride solution
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Thomas Staudinger
Spinal Cord Injuries, Venous Thromboembolism
Apixaban For Thromboprophylaxis In Patients With Acute Spinal Cord Injury
Thromboprophylaxis options are limited for patients with acute spinal cord injury (SCI) and there are no studies on direct oral anticoagulants (DOACs) for thromboprophylaxis in this population.
- Trial name
- NCT03200613
- Testing
- Apixaban, Low molecular weight heparin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Venous Thromboembolism, Deep Vein Thrombosis
Inter-observer Reliability of the TRiP(Cast) Score in Patients With Trauma to a Lower Limb Requiring Immobilisation
The aim of the study isto evaluate the inter-observer reliability of the assessment of venous thromboembolic risk using the TRiP(cast) score in patients presenting with trauma to a lower limb requiring immobilisation, and of the…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism, Thromboprophylaxis
- Trial name
- CCASTING (NCT06416280)
- Testing
- Assessment of the TRiP(cast) score
- Where
- France
- Volunteers
- 302 people
- Sponsor
- University Hospital, Angers
Polycythemia Vera, Essential Thrombocythemia
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms
Philadelphia-negative myeloproliferative neoplasms (MPN) are frequent and chronic myeloid malignancies including Polycythemia Vera (PV), essential thrombocythemia (ET), Primary Myelofibrosis (PMF) and Prefibrotic myelofibrosis…
- Conditions
- Polycythemia Vera, Essential Thrombocythemia, Prefibrotic/Early Primary Myelofibrosis, JAK2 V617F
- Trial name
- AVAJAK (NCT05198960)
- Testing
- Direct Oral Anticoagulants, Low-dose aspirin
- Where
- 42 sites in France
- Volunteers
- 1,308 people
- Sponsor
- University Hospital, Brest
Treatment of Venous Thromboembolism in Cancer Patients
A Study to Gather Information About Rivaroxaban in Patients in the United Kingdom Who Have Cancer and Thrombosis (OSCAR-UK)
Patients with cancer are more likely than those without cancer to develop blood clots (deep vein thrombosis and pulmonary embolism), which are treated using blood thinners (anticoagulants).
- Trial name
- NCT05112666
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), other DOACs, LMWH
- Where
- United Kingdom
- Volunteers
- 2,601 people
- Sponsor
- Bayer
Postpartum Hemorrhage, Systemic Autoimmune Diseases
Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage
Postpartum hemorrhage (PPH) is the most significant leading cause of pregnancy-related mortality in high-risk cesarean delivery women.
- Trial name
- NCT06754371
- Testing
- tranexamic acid, normal saline
- Where
- China
- Volunteers
- 276 people
- Sponsor
- RenJi Hospital
Venous Thromboembolism (VTE)
Evaluation of the Predictive Value of the Microvesicle Coagulo-lytic Balance in the Recurrence of Venous Thrombosis
Venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) affects about 1,200,000 individuals each year in Europe.
- Trial name
- MICROREVE (NCT03265054)
- Testing
- Analysis of plasma samples
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pulmonary Embolism
Reduced Dose Thrombolytic in Intermediate/High Risk Pulmonary Thromboembolism
Pulmonary Embolism(PE) requires multidisciplinary approach as a highly morbid and mortal disease. This multidisciplinary approach creates clinical benefits in diagnostic and therapeutic process.
- Trial name
- NCT05512702
- Testing
- Tissue Plasminogen Activator, Alteplase, Low-molecular weight heparin
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ege University
Venous Thromboembolism
Rivaroxaban (10mg) Given Once Daily in Patients Undergoing Total Hip Replacement Compared to Enoxaparin
The purpose of this study is to assess if 10 mg BAY 59-7939, taken once daily as a tablet, is safe and prevent blood clot which may form after total hip replacement operation.
- Trial name
- NCT00329628
- Testing
- Rivaroxaban (BAY59-7939), Enoxaparin
- Where
- 215 sites in United States, Argentina and 26 more
- Volunteers
- 4,541 people
- Sponsor
- Bayer
Venous Thromboembolism, Brain Tumors
The Roles of Tissue Factor in Malignant Gliomas
To explore the relationship between tissue factor levels, tumour progression, activation of blood coagulation and venous thromboembolism with malignant glioma
- Trial name
- NCT00201903
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Bradyarrhythmias, Arrhythmias
Thromboembolic Complications After Pacemaker or Implantable Cardioverter-Defibrillator Procedures
This is a large prospective registry of patients submitted to cardiac electronic devices implantation designed to investigate the incidence, risk factors and prognostic of thromboembolic complications associated with transvenous…
- Conditions
- Bradyarrhythmias, Arrhythmias, Cardiovascular Disease, Venous Thrombosis
- Trial name
- NCT01717495
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- University of Sao Paulo
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