Clinical trials: Thromboembolic Disease
Venous Thromboembolism, Pancreatic Cancer
Venous Thromboembolism in Primary Pancreatic Tumour Resection
This study will evaluate the development of venous thromboembolism (VTE) and possible determinants in patients with primary pancreatic cancer undergoing pancreatic cancer resection.
- Conditions
- Venous Thromboembolism, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
- Trial name
- PaTR-VTE (NCT05964621)
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- University of Thessaly
Venous Thromboembolism
Prevention of Venous Thromboembolic Events After Elective Orthopaedic Surgery in Patients Treated With PRADAXA
Observational cohort study on the prevention of venous thromboembolic events after elective orthopaedic surgery for Total Knee Replacement or Total Hip Replacement iin patients treated with PRADAXA to evaluate the efficacy ant…
- Trial name
- NCT01139658
- Where
- 53 sites in France
- Volunteers
- 1,676 people
- Sponsor
- Boehringer Ingelheim
Blood Clot, Trauma
PREVENTion of Clot in Orthopaedic Trauma
The purpose of this study is to compare aspirin versus low-molecular weight heparin (LMWH) (Enoxaparin) as a thromboprophylaxis in patients who sustain a fracture.
- Trial name
- PREVENT CLOT (NCT02984384)
- Testing
- Acetylsalicylic acid, Low Molecular Weight Heparin (LMWH)
- Where
- 21 sites in United States, Canada
- Volunteers
- 12,424 people
- Sponsor
- Major Extremity Trauma Research Consortium
Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension
cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment
- Conditions
- Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)
- Trial name
- CPETPH (NCT02061787)
- Testing
- balloon pulmonary angioplasty
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Thromboembolism
A Comparison of Certoparin and Unfractionated Heparin in the Prevention of Thromboembolic Events in Acutely Ill Medical Patients
This study is designed to provide efficacy and safety data for certoparin in the prophylaxis of venous thromboembolism in immobilized, acutely ill medical patients.
- Trial name
- NCT00451412
- Testing
- Certoparin, Unfractionated Heparin
- Where
- Germany
- Volunteers
- 3,254 people
- Sponsor
- Novartis
Arthritis, Osteoarthritis, Knee
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
The study will describe the short-term effects the study drug, rivaroxaban, has on the body when a patient is switched from enoxaparin injection (by needle) to oral rivaroxaban (by mouth) for the prevention of blood clotting in…
- Conditions
- Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
- Trial name
- NCT01094886
- Testing
- Rivaroxaban
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Venous Thromboembolism, Major Bleed
Direct Oral Anticoagulants and Venous Thromboembolism
The purpose of this study is to determine whether use of direct oral anticoagulants (DOACs) is associated with an increased risk of major bleeding compared to warfarin use, for the treatment of venous thromboembolism (VTE).
- Trial name
- NCT02833987
- Testing
- Apixaban (ATC B01AF02), Dabigatran (ATC B01AE07), Rivaroxaban (ATC B01AF01)
- Where
- Canada
- Volunteers
- 59,525 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Quality of Health Care
Prevention of Venous Thromboembolism Disease in Emergency Departments
The appropriate use of thromboprophylaxis in medical patients admitted to hospital can substantially reduce the overall burden of disease due to venous thromboembolism.
- Trial name
- PREVENU (NCT01212393)
- Testing
- reminders
- Where
- 23 sites in France
- Volunteers
- 20,000 people
- Sponsor
- University Hospital, Angers
Pulmonary Embolism (Diagnosis), Venous Thromboembolism (VTE)
3D-EIT for Diagnosis and Monitoring of Pulmonary Embolism
This prospective observational study aims to validate three-dimensional electrical impedance tomography (3D-EIT) as a non-invasive bedside tool for the diagnosis and longitudinal monitoring of pulmonary embolism (PE).
- Trial name
- TIDE-PE (NCT07560293)
- Volunteers
- 115 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPH
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are severe clinical conditions that, despite advances in therapeutics over the past 20 years, lead to serious morbidity and…
- Trial name
- NCT05618093
- Testing
- Non-invasive hemodynamic measurements
- Where
- United States
- Sponsor
- University of California, Los Angeles
Covid19, Venous Thromboembolism
Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE Trial
The Michelle trial is expected to provide high-quality evidence around the role of extended thromboprophylaxis in COVID-19 and will help guide medical decisions in clinical practice.
- Trial name
- MICHELLE (NCT04662684)
- Testing
- Rivaroxaban 10 MG
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- Science Valley Research Institute
Sinus Thrombosis, Intracranial
Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis
Background: Endovascular thrombolysis, with or without mechanical clot removal (ET), may be beneficial for a subgroup of patients with cerebral venous sinus thrombosis (CVT), who have a poor prognosis despite treatment with…
- Trial name
- TOACT (NCT01204333)
- Testing
- Endovascular thrombolysis, Heparin
- Where
- 15 sites in Canada, China and 4 more
- Volunteers
- 67 people
- Sponsor
- Jan Stam, MD, PhD
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Decision Aid for Anticoagulation Duration After Unprovoked Venous Thromboembolism
Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a common condition that is typically treated with blood thinners (anticoagulants).
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism
- Trial name
- DECIDE-VTE (NCT07659106)
- Testing
- DECIDE-VTE Patient Decision Aid
- Where
- 5 sites in Canada
- Volunteers
- 850 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Neoplasm, Venous Thromboembolism
Cancer Associated Thrombosis, a Pilot Treatment Study Using Rivaroxaban
The study will compare the efficacy and safety of oral rivaroxaban and subcutaneous dalteparin in patients with cancer associated thrombosis.
- Trial name
- CASTA-DIVA (NCT02746185)
- Testing
- rivaroxaban, Low-molecular-weight heparin
- Where
- 15 sites in France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prevention of Venous Thromboembolism
Efficacy And Safety Of Unfractionated Heparin In Patients With Cardiovascular Surgery Using Cardiopulmonary Bypass
The primary objective of this study is to verify, through a randomized, blinded, parallel clinical trial, the efficacy of bovine heparin from Bergamo Laboratory ACTIPARIN ® product when compared to porcine heparin APP…
- Trial name
- NCT01072747
- Testing
- bovine heparin, Porcine heparin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Azidus Brasil
Machine Learning, Chronic Obstructive Pulmonary Disease
Machine Learning-based Models in Prediction of DVT and PTE in AECOPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory system disease characterized by persistent respiratory symptoms and irreversible airflow restriction, which seriously endangers people's health.
- Conditions
- Machine Learning, Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease With Acute Exacerbation, Unspecified, Pulmonary Thromboembolisms
- Trial name
- NCT05905874
- Testing
- Machine learning-based prediction model
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- West China Hospital
Critical Illness, Therapeutic Drug Monitoring
Anti-Xa Level With Thromboprophylactic Dosage Nadroparin in Critically Ill COVID-19 and Non-COVID-19 Patients
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose…
- Conditions
- Critical Illness, Therapeutic Drug Monitoring, Venous Thromboembolism
- Trial name
- NADRO (NCT05926518)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Rijnstate Hospital
Chronic Thromboembolic Pulmonary Hypertension
Hemodynamic Effects of BPA at Rest and During Exercise in CTEPH
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of the pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular resistance (PVR), progressive pulmonary…
- Trial name
- EXPERT-BPA (NCT04052243)
- Testing
- Invasive exercise testing
- Where
- 3 sites in Denmark, Japan and 1 more
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Venous Thromboembolism, Deep Venous Thrombosis
Rate of Venous Thrombosis in Acutely Ill Patients Hospitalized in Internal Medicine Wards
After reports from observational studies suggesting an association between acutely ill medical patients and venous thromboembolism (VTE), interventional trials with anticoagulants drugs have demonstrated a significant reduction…
- Trial name
- AURELIO (NCT03157843)
- Testing
- low-molecular-weight heparin
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Corona Virus Infection, Thromboembolic Disease
Thrombosis Risk Assessment and Clinical Presentation of Covid-19 Pneumonia
Covid-19 mainly affects the respiratory system. Multiple organ dysfunction and a particularly progressive respiratory insufficiency along with a widespread coagulopathy presumed to be due to infection-associated inflammation and…
- Trial name
- Covid-19 (NCT04423315)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Nisantasi University
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