Clinical trials: Thromboembolic Disease
Deep Vein Thrombosis, Pulmonary Embolism
Prophylaxis of Thromboembolic Complications Trial: Thromboprophylaxis Needed in Below Knee Plaster Cast Immobilization for Ankle and Foot Fractures
Objective: The purpose of this study is to determine the need for thromboprophylaxis in patients with a fracture of the lower extremity being treated conservatively in a below-knee plaster cast and to assess if both of the two…
- Trial name
- PROTECT (NCT00881088)
- Testing
- Nadroparin, Fondaparinux
- Where
- 5 sites in Netherlands
- Volunteers
- 669 people
- Sponsor
- Red Cross Hospital Beverwijk
Advanced Cancer, Metastatic Cancer
Prevention of Venous and Arterial Thromboembolism, in Cancer Patients Undergoing Chemotherapy, With a Low Molecular Weight Heparin (Nadroparin Calcium)
In this phase III, multicenter study, 1200 patients with lung, breast, gastrointestinal (stomach, colon-rectum, pancreas), ovarian or head and neck cancer undergoing chemotherapy will be randomly assigned (at the beginning of…
- Trial name
- NCT00951574
- Testing
- Nadroparin calcium
- Where
- 46 sites in Italy
- Volunteers
- 1,166 people
- Sponsor
- Italfarmaco
Venous Thromboembolism
The Role of Platelet TLRs in Platelet Activation During VTE
Venous thromboembolic disease (VTE) is a frequent and potentially serious pathology. Therapeutic management has improved considerably over the last few decades, enabling the application of codified management in line with the…
- Trial name
- ROT-PLAT-VTE (NCT06257290)
- Testing
- blood sample
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Deep Venous Thrombosis
The Clinical Application of Infrared Thermal Imaging Detecting Venous Thromboembolism
The purpose of this study is to determine the effectiveness of infrared thermal imaging in adjunctive diagnostic screening for lower limb deep venous thrombosis (DVT).
- Trial name
- NCT02552420
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Hypertension, Pulmonary, Hypertension;Pulmonary;Primary
Endtidal Carbon Dioxide for Earlier Detection of Pulmonary Hypertension
Measurement of the endtidal carbon dioxide by capnography to exclude or to ensure the diagnosis pulmonary hypertension. The aim of the study is to obtain an endtidal carbon dioxide cut-off value for the diagnostic algorithm for…
- Conditions
- Hypertension, Pulmonary, Hypertension;Pulmonary;Primary, Chronic Thromboembolic Pulmonary Hypertension, Vascular Diseases
- Trial name
- EARLIER (NCT03388476)
- Testing
- Capnography
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Venous Thromboembolic Disease, Post Thrombotic Syndrome
Long-term Outcome After Edoxaban Versus Vitamin K Antagonists for Acute VTE
The HOKUSAI post VTE study contains of two different research questions; one on the long term outcomes of deep vein thrombosis and one on the long term effects of pulmonary embolism, post thrombotic syndrome (PTS) and chronic…
- Conditions
- Venous Thromboembolic Disease, Post Thrombotic Syndrome, Chronic Thromboembolic Pulmonary Hypertension, Quality of Life
- Trial name
- HOKUSAIpostVTE (NCT04007653)
- Testing
- Observation
- Where
- Netherlands
- Volunteers
- 1,200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cancer, Thrombosis
Anticoagulation Length in Cancer Associated Thrombosis
This is a two year, multicentre, mixed methods feasibility study including a randomised controlled two-arm interventional trial, a nested qualitative study, focus groups and a United Kingdom (UK) wide survey exercise.
- Conditions
- Cancer, Thrombosis, Venous Thromboembolism, Deep Vein Thrombosis
- Trial name
- ALICAT (NCT01817257)
- Testing
- Low Molecular Weight Heparin (LMWH)
- Where
- 5 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- Cardiff University
Venous Thromboembolism, Deep Vein Thrombosis
A Phase 2b Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty
The objective of this study is to assess the efficacy, safety and dose-response relationship of DU-176b compared with placebo for the prevention of venous thromboembolism in patients after elective total knee arthroplasty.
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Total Knee Arthroplasty
- Trial name
- NCT01203072
- Testing
- DU-176b
- Where
- 2 sites in Japan
- Volunteers
- 523 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
VTEval Project - Prospective Cohort Studies to Evaluate and Improve Diagnostics, Management Strategies and Risk Stratification in VTE
Venous thromboembolism (VTE) with its two clinical manifestations deep vein thrombosis (DVT) and pulmonary embolism (PE) is a life-threatening disease that is associated with considerable morbidity and mortality.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE)
- Trial name
- VTEval (NCT02156401)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Thrombosis
Clinical Assessment of Thrombosis in Children After Heart Surgery
Thromboembolic complications (TCs) are important causes of morbidity and mortality after pediatric cardiac surgery, resulting in longer hospital stay, increased risk of early and late post-surgical complications, early…
- Trial name
- CATCH (NCT01435473)
- Testing
- Cardiac Surgery
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- The Hospital for Sick Children
Venous Thromboembolic Disease
Observational Prospectif Monocentric Registry of Patients Suffering From VIE
Patients with an episode of VTE (DVT and / or PE) have a mortality rate of 16-21% at 1 year after diagnosis. Morbidity associated with VTE is marked by the risk of recurrence, estimated at 30% and estimated at 29% after 8 years…
- Trial name
- REMOTEV (NCT02188056)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Venous Thromboembolism, Risk Assessment
Multiple Algorithms System Of All Scores in Embolism (MOSE)
The aim of this study is to overcome the current limits of the scoring systems used to predict both the thrombotic (VTE) and hemorrhagic (BLD) risk for the patient.
- Conditions
- Venous Thromboembolism, Risk Assessment, Risk Management
- Trial name
- MOSE (NCT02911012)
- Where
- 2 sites in Italy
- Volunteers
- 15,208 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Atrial Fibrillation
Cerebral Embolism (CE) in Catheter Ablation of Atrial Fibrillation (AF)
Radiofrequency catheter ablation of atrial fibrillation (AF) induces a procoagulant state, which leads to an acute risk for symptomatic cerebral embolism (CE) of approximately 1%.
- Trial name
- CE-AF (NCT01361295)
- Testing
- PVI with PVAC gold, PVI with Cooled-RF
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Serge A. Trines
Heavy Menstrual Bleeding
Prospective Comparison of Incidence of Heavy Menstrual Bleeding in Women Treated With Direct Oral Anticoagulants
Prospective comparison of the incidence of heavy menstrual bleeding (HMB) in women of reproductive age treated with direct oral anticoagulants (DOACs)
- Trial name
- NCT04477837
- Testing
- Apixaban 5 MG, Rivaroxaban 20 MG, Edoxaban 60 MG
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Thrombosis
A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagonist (VKA) or Low Molecular Weight Heparin (LMWH) in Pediatric Subjects With Congenital or Acquired Heart Disease Requiring Anticoagulation
To investigate the safety and pharmacokinetics of apixaban in children with congenital or acquired heart disease who have a need for anticoagulation.
- Trial name
- NCT02981472
- Testing
- Apixaban, Vitamin K Antagonist (VKA), Low Molecular Weight Heparin (LMWH)
- Where
- 46 sites in United States, Argentina and 12 more
- Volunteers
- 192 people
- Sponsor
- Bristol-Myers Squibb
Deep Vein Thrombosis (DVT), Thrombus in the Peripheral Venous Vasculature
Cleaner Long-tErm Assessment Registry - Venous Insights and Efficacy With eXtended Tracking
The primary objective of this clinical investigation is to evaluate the safety and effectiveness of the Cleaner Vac® Thrombectomy System for the treatment of thrombus in patients with lower extremity proximal deep vein thrombosis…
- Conditions
- Deep Vein Thrombosis (DVT), Thrombus in the Peripheral Venous Vasculature, Venous Embolism, Thrombus in the Central and Peripheral Circulatory System, Including Saphenous Vein Grafts
- Trial name
- CLEAR-VIEW XT (NCT07102160)
- Testing
- Aspiration thrombectomy system
- Where
- 4 sites in United States
- Volunteers
- 185 people
- Sponsor
- Argon Medical Devices
Covid19, Thromboembolism
Dosing of Thromboprophylaxis and Mortality in Critically Ill COVID-19 Patients
The aim of the study is to associate dose of thromboprophylaxis with outcome in critically ill COVID-19 patients. This will be done by associating dose of thromboprophylaxis with 28-day mortality, survival outside ICU…
- Trial name
- NCT04593654
- Testing
- Dose of tinzaparin or dalteparin
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Karolinska Institutet
Atrial Fibrillation, Cancer
Atrial Fibrillation and Cancer: a Nationwide French Cohort Study
Atrial fibrillation (AF) is a common complication associated with cancer but the risk of AF according to the cancer localization and status as well as the risk of thromboembolisms, bleedings and mortality are poorly known.
- Conditions
- Atrial Fibrillation, Cancer, Thromboembolism, Bleeding
- Trial name
- NCT05563883
- Testing
- event occurence
- Where
- France
- Volunteers
- 5,000,000 people
- Sponsor
- University Hospital, Caen
Venous Thromboembolism, Atrial Fibrillation
Observatory of Invasive Procedures and Bleeding in Patients Treated With New Oral Anticoagulants
The arrival on the market of direct oral factor Xa and factor IIa inhibitors (dabigatran (Pradaxa®), rivaroxaban (Xarelto®), apixaban (Eliquis®) and others soon to come) raises novel questions among clinicians confronted with the…
- Trial name
- GIHP-NACO (NCT02185027)
- Testing
- complications and compliance with GIHP recommendations
- Where
- 41 sites in Belgium, France
- Volunteers
- 1,166 people
- Sponsor
- University Hospital, Grenoble
Venous Thromboembolism
Efficacy and Safety of TAK-442 in Subjects Undergoing Total Knee Replacement
The purpose of this study is to determine if TAK-442, once daily (QD) or twice daily (BID), is as safe and effective as enoxaparin in preventing the development of blood clots after knee replacement surgery.
- Trial name
- NCT00641732
- Testing
- TAK-442, Enoxaparin
- Where
- 64 sites in United States, Canada
- Volunteers
- 1,045 people
- Sponsor
- Takeda
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