Clinical trials: Thromboembolic Disorders
Primary Immune Deficiency Disorder
Octagam 5% Versus Comparator Post Marketing Trial
Study Design: This is a 2 arm non-interventional trial that will compare the occurrence of adverse drug reactions between Octagam 5% and other marketed IVIG infusion treatments.
- Trial name
- NCT01859754
- Testing
- Octagam 5%, Other marketed IVIG product
- Where
- 27 sites in United States
- Volunteers
- 623 people
- Sponsor
- Octapharma
Breast Cancer, Colorectal Cancer
Incidence of Blood Clots in Patients Undergoing Chemotherapy for Solid Tumors
RATIONALE: Chemotherapy may cause blood clots to form in the thigh, leg, and lung. This study may help doctors understand how often blood clots occur in patients undergoing chemotherapy.
- Conditions
- Breast Cancer, Colorectal Cancer, Gastric Cancer, Lung Cancer
- Trial name
- NCT00433602
- Testing
- clinical observation, management of therapy complications, ultrasound imaging
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Thromboembolic Disease Recurrent, Deep Vein Thrombosis
Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis (PREDICTORS)
Patients with a history of blood clots are at risk of developing additional clots in the future. Doctors use a tool called a clinical decision rule to tell them how likely it is that a patient has a blood clot and if they should…
- Conditions
- Thromboembolic Disease Recurrent, Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- PREDICTORS (NCT02297373)
- Where
- 9 sites in Canada, Netherlands and 1 more
- Volunteers
- 744 people
- Sponsor
- Ottawa Hospital Research Institute
Venous Thromboses, Thromboembolic Disease
Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)
Thrombo-embolic venous diseases are represented by deep venous thrombosis and/or pulmonary embolism. In some patients with repeated thrombosis or occurrence of thrombosis in unusual sites, the etiological workup remains negative…
- Conditions
- Venous Thromboses, Thromboembolic Disease, Neutrophil Extracellular Trap Formation, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- CLODETTE (NCT05711173)
- Testing
- Additional blood sampling
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Fetal Demise, Fetal Growth Restriction
Dose Adjusting Enoxaparin Thromboprophylaxis Dosage According to Anti-factor Xa Plasma Levels Improve Pregnancy Outcome
The risk of venous thromboembolism increases in pregnancy. Thrombophilia whether genetic or acquired, is a hypercoagulable disorder that may increase the risk of venous thromboembolic events.
- Conditions
- Fetal Demise, Fetal Growth Restriction, Preeclampsia, Abruptio Placentae
- Trial name
- NCT01068795
- Testing
- enoxaparin
- Where
- Israel
- Volunteers
- 144 people
- Sponsor
- HaEmek Medical Center, Israel
Stroke, Acute, Carotid Artery Diseases
Platelet Function and Neurological Events
Several studies have shown an association between platelet function and stroke in patients undergoing carotid thromboendarterectomy (TEA).
- Trial name
- MULTINEUR (NCT05572320)
- Testing
- Platelet Aggregometry Testing
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- Scientific Institute San Raffaele
Ischemic Stroke, Thromboembolic Stroke
Intracranial Rescue Stenting for Acute Ischemic Stroke, Predictors of Outcomes
The use of rescue intracranial stenting is thought to be associated with better outcomes than with patients received medical treatment only after failed thrombectomy as Reperfusion technique.
- Trial name
- NCT04987710
- Testing
- intracranial rescue stenting
- Volunteers
- 25 people
- Sponsor
- Assiut University
Pulmonary Embolism
Study on the Effect of a Physical Training Structured Program After a Pulmonary Thromboembolism
Exercise training, as the core component of a Pulmonary Rehabilitation program, may help restore arterial blood flow in the lungs of patients who had suffered Pulmonary Embolism (PE), stimulating and promoting vasodilator…
- Trial name
- TEP-RR (NCT04150003)
- Testing
- Pulmonary Rehabilitation program, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 144 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Women's Health, Blood Coagulation Disorders
The Effect of the Mini-pill on Blood Factors in Women at Increased Risk for Forming Blood Clots
We propose a prospective cohort study to assess the effect of the progesterone only contraceptive pill (minipill) on coagulation parameters known to be associated with risk of thrombosis (blood clots) in women who are at…
- Trial name
- NCT00580424
- Testing
- Norethindrone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia
Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia
This pilot clinical trial compares the safety of two different platelet transfusion "thresholds" among patients with blood cancer or treatment-induced thrombocytopenia whose condition requires anticoagulant medication (blood…
- Conditions
- Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma
- Trial name
- NCT03195010
- Testing
- Platelet Transfusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Fred Hutchinson Cancer Center
Venous Thromboembolic Disease
Cohort for Monitoring Patients With Venous Thromboembolic Disease
Venous thromboembolic disease is a common pathology in the general population (1.5/1000), the prognosis of which depends in particular on the risk of recurrence.
- Trial name
- CoMTEV (NCT07016542)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Rouen
Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension
the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension
cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment
- Conditions
- Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)
- Trial name
- CPETPH (NCT02061787)
- Testing
- balloon pulmonary angioplasty
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Atherosclerotic Vascular Disease, Coronary Arterial Disease (CAD)
Genetic Testing of CYP2C19 in Prognostic Evaluation of Long-Term Major Adverse Cardiac and Vascular Events
Several studies have shown that the efficacy of clopidogrel for secondary prevention of major adverse cardiovascular events (MACE), including acute coronary syndrome, depends on the polymorphism of the CYP2C19 gene.
- Conditions
- Atherosclerotic Vascular Disease, Coronary Arterial Disease (CAD), Atherosclerosis of Coronary Artery, Atherosclerosis of Arteries of the Extremities, Unspecified
- Trial name
- UF-GENOTYPE (NCT06855394)
- Where
- 2 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- University of Florida
Atrial Fibrillation, Stroke
Galectin-3 for Thromboembolic Formation in Patients With Atrial Fibrillation CHA₂DS₂-VASc Scoring
Atrial Fibrillation is considered as one of a common cardiac arrhythmia that presented with rapid and irregular rhythm and has an increased incidence.There are different types of atrial fibrillation one of these is paroxysmal…
- Trial name
- NCT03413072
- Volunteers
- 140 people
- Sponsor
- Assiut University
Coronary Artery Disease, Valvular Heart Disease
Prehabilitation for Patients Undergoing Elective Cardiac Surgery
The objective of this clinical trial is to develop a novel rehabilitation model that, through the PRECICA program, will help to reduce perioperative and postoperative complications in the care process prior to planned cardiac…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Chronic Thromboembolic Pulmonary Hypertension, Aortic Diseases
- Trial name
- PRECICA (NCT07704086)
- Testing
- Physical exercise, Educational program and respiration physiotherapy
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Hospital Universitario 12 de Octubre
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Dapagliflozin in Pulmonary Arterial Hypertension
The purpose of this study is to investigate the effects of dapagliflozin on exercise capacity and hemodynamics in patients with pulmonary arterial hypertension
- Trial name
- DAPAH (NCT05179356)
- Testing
- Dapagliflozin 10 MG [Farxiga]
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- Mads Ersbøll
Polycythemia Vera
Study to Identify and Describe Predictive Factors for Thromboembolic Events in Patients With High-risk Polycythemia Vera
This is a prospective observational study that will enroll patients with high-risk Polycythemia Vera (PV) with at least one Thromboembolic Event (TE) after diagnosis or up to 2 years prior to diagnosis.
- Trial name
- Prospero (NCT05548062)
- Testing
- Hydroxyurea, Ruxolitinib
- Where
- 33 sites in Italy
- Volunteers
- 242 people
- Sponsor
- Novartis Pharmaceuticals
Atrial Fibrillation
Non-pharmacological Prevention of Stroke in Patients With Non-valvular Atrial Fibrillation
Left atrial appendage (LAA) occlude devices are used for over ten years. According to current data efficiency and safety of this approach at least comparable with pharmacological prevention of stroke in patients with non-valvular…
- Trial name
- NCT03867227
- Testing
- left atrial appendage occluder implantation
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- National Research Center for Preventive Medicine
Venous Thromboembolism
Venous Thromboembolic Event (VTE) Prophylaxis in Medically Ill Patients
This study will evaluate if extended therapy with oral rivaroxaban can prevent blood clots in the leg and lung that can occur with patients hospitalized for acute medical illness, and compare these results with those of the…
- Trial name
- MAGELLAN (NCT00571649)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Enoxaparin
- Where
- 676 sites in United States, Argentina and 51 more
- Volunteers
- 8,101 people
- Sponsor
- Bayer
Critical Illness, Sepsis
Neuromuscular Stimulation Versus Intermittent Compression for Venous Thromboembolism Prophylaxis in Critical Care
In this prospective, randomised, open-label, parallel group, feasibility trial; the investigators will objectively assess whether it is feasible to apply the Geko device to critically ill adults for the prevention of venous…
- Conditions
- Critical Illness, Sepsis, Acute Illness, Venous Thromboembolism
- Trial name
- ENSARIA (NCT05208216)
- Testing
- Geko device, Flowtron DVT
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Manchester University NHS Foundation Trust