Clinical trials: Thrombophilia
Hepatic Disease, Surgery-Complications
Prolonged Hypercoagulability Following Major Liver Resection for Malignancy
This clinical trial will investigate the ability of thromboelastrogrpahy (TEG®) to detect hypercoagulability after liver surgery and will examine the effect of extended thromboprophylaxis (medical treatment to prevent the…
- Conditions
- Hepatic Disease, Surgery-Complications, Hypercoagulability, Thrombosis
- Trial name
- PRIORITY (NCT06153394)
- Testing
- Redesca (enoxaparin sodium for injection), Fragmin (dalteparin)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Acute Respiratory Failure, Hypercoagulability
Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure
Patients with coronavirus disease (COVID) and non-COVID acute respiratory failure (ARF) may be at an increased risk of thrombosis due to increased clot formation and decreased clot lysis.
- Conditions
- Acute Respiratory Failure, Hypercoagulability, Fibrinolysis Shutdown
- Trial name
- VETtiPAT-ARF (NCT05540834)
- Testing
- Alteplase
- Where
- Australia
- Volunteers
- 70 people
- Sponsor
- South West Sydney Local Health District
Thrombophilia
Thrombophilia Assessment Under DOAC: Effectiveness of Activated Charcoal
Direct oral anticoagulants (DOAC) are anticoagulant molecules that act either directly on factor Xa (Apixaban, Rivaroxaban) or on factor IIa (Dabigatran).
- Trial name
- DOAC-Stop (NCT06171984)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Menopause, Thrombophilia
Effect of DT56a (Femarelle) on the Coagulation System in the Treatment of Postmenopausal Women
The purpose of this study is to determine if Femeralle (DT56a) has an effect on the coagulation system, measured by platelet adhesion and aggregation, of normal and thrombophilic postmenopausal women.
- Trial name
- NCT00883272
- Testing
- DT56a (Femarelle) [Se-cure pharmaceuticals, Dalton, Israel]
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Livedoid Vasculitis
Livedoid Vasculopathy: Strong Association With Smoking, Weak Association With Thrombophilia
A screening of patient histories at the clinics of Dermatology of the universities of Zurich, Basel and Bern is performed in order to identify patients with a history of Livedoid vasculopathy.
- Trial name
- NCT05878327
- Testing
- Thrombophilia screening
- Where
- 3 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- University of Zurich
Ischemic Stroke, Stroke in the Young
Observational Dutch Young Symptomatic StrokE studY - nEXT
BACKGROUND: Worldwide, 2 million patients aged 18-50 years suffer an ischemic stroke each year with an increasing trend over the past decade due to yet unknown reasons.
- Conditions
- Ischemic Stroke, Stroke in the Young, Cardiovascular Diseases, Cerebrovascular Disorders
- Trial name
- ODYSSEY-nEXT (NCT05853796)
- Where
- 6 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Hypercoagulability, Obesity
Effect of Phototherapy With Exercise on Coagulation in Elderly
It is an interventional study in which 60 obese elderly patients (30 male \& 30 female) estimated to enroll according to random allocation and divided into two groups.
- Trial name
- NCT04503317
- Testing
- active acupuncture low level laser in addition to nasal laser irradiation, treadmill exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
COVID-19
Therapeutic Plasma Exchange for COVID-19-associated Hyperviscosity
Many patients with Coronavirus Disease 2019 (COVID-19) have atypical blood clots. These blood clots can occur in either veins or arteries and be large, like in stroke or heart attack, or very tiny, called microthrombi.
- Trial name
- NCT04441996
- Testing
- Therapeutic plasma exchange (TPE), Standard of care
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Covid19
Extracorporeal Blood Purification as a Treatment Modality for COVID-19
Several studies have suggested a potential clinical benefit of controlling hyper inflammation triggered by SARS-CoV-2/COVID-19. Blood purification, the removal of excessive proinflammatory mediators may control disease…
- Trial name
- NCT04478539
- Testing
- Extracorporeal blood purification using the oXiris® (AN69ST) hemofilter
- Where
- North Macedonia
- Volunteers
- 35 people
- Sponsor
- Zan Mitrev Clinic
IUGR, Thrombophilia
Thrombophilia Screening After Severe IUGR
This retrospective study aims to assess the input of thrombophilia screening in pregnant women with severe intra-uterine growth restricted babies.
- Conditions
- IUGR, Thrombophilia, Pregnancy Complications
- Trial name
- NCT05551078
- Testing
- thrombophilia screening
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Infertility, Female, Thrombophilia
Effect of Prophylatic Use of Enoxaparin in Women Undergoing in Vitro Fertilization Treatment
Retrospective study designed to evaluate outcomes in patients undergoing assisted reproduction. Some of them had thrombophilia, and part of them was treated with enoxaparin, started on the day of embryo transfer, and the other…
- Conditions
- Infertility, Female, Thrombophilia, Fertilization in Vitro
- Trial name
- NCT05225155
- Testing
- Enoxaparin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Faculdade de Medicina do ABC
Cirrhosis
Rôle of the Soluble Endothelial Protein C Receptor in Cirrhosis-associated Hypercoagulability State (EXERCISE)
Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This damage is characterized by the replacement of normal liver tissue by scar tissue.
- Trial name
- EXERCISE (NCT03625726)
- Testing
- Thrombin generation assay (in vitro)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Anticoagulation, Atrial Fibrillation
AntiCoagulation Tracking InterVention and Evaluation
Anticoagulants are a leading cause of acute injury from adverse drug events, leading to ~20,000 serious injuries reported to the Food and Drug Administration per year and more than 220,000 emergency department visits annually.
- Conditions
- Anticoagulation, Atrial Fibrillation, Atrial Flutter, Pulmonary Embolus/Emboli
- Trial name
- ACTIVE (NCT04059965)
- Testing
- Panel Management for Anticoagulation Therapy, Usual Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Covid19, Corona Virus Infection
Effect of Prophylactic and Therapeutic Anticoagulants in Egyptian Patients With COVID-19
Since the end of 2019, Egypt and the whole world have been suffering from the Coronavirus Disease 2019 (COVID-19) pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Conditions
- Covid19, Corona Virus Infection, Hypercoagulability
- Trial name
- NCT04736901
- Testing
- Enoxaparin, Rivaroxaban, Apixaban
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Sickle Cell Disease, Vaso-occlusive Crisis
Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)
Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain.
- Trial name
- SCD-TGA (NCT05376046)
- Testing
- Erythrocytic parameters and thrombin generation assay measurement
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- BILLOIR
Thromboembolic Venous Disease
New Genetic Mutations in Thromboembolic Venous Disease Idiopathic. Study "FIT GENETIQUE".
Identify new genetic mutations predisposing to an increased risk of VTE by locating and / or identifying genes involved in subjects at high risk for thrombotic and in whom screening for detectable hereditary thrombophilia was…
- Trial name
- Fit-Génétique (NCT02841085)
- Testing
- Genetic sample
- Where
- France
- Volunteers
- 613 people
- Sponsor
- University Hospital, Brest
COVID-19 Pneumonia, Embolism
Embolism in COVID-19 Positive Patients
Covid-19 outbreak has caused death of millions of people because of not only the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection itself but also infection dependent complications.
- Conditions
- COVID-19 Pneumonia, Embolism, Genetic Predisposition
- Trial name
- NCT04910360
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis
Analysis of Neutrophil Extracellular Traps in Hypercoagulability and Portal Vein Thrombosis in Liver Cirrhosis Patients
The aim of this study was to investigate whether NETs markers can enhance procoagulant activity and predict portal vein thrombosis in patients with live cirrhosis, so as to establish a novel predictor to guide clinical…
- Conditions
- Neutrophil Extracellular Trap Formation, Portal Vein Thrombosis, Liver Cirrhosis
- Trial name
- NCT05012501
- Testing
- test NETs markers
- Where
- China
- Volunteers
- 79 people
- Sponsor
- The Affiliated Hospital of Qingdao University