Clinical trials: Thrombophilia
Beta Thalassemia Major Anemia
Thrombin Generation in Beta-thalassemia Major
This study aims to evaluate the persistence of a hypercoagulable state in chronically-transfused patients with beta thalassemia major, by using the thrombin generation test (performed in whole blood and plasma).
- Trial name
- TG-THAL (NCT04962984)
- Testing
- blood sampling
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications
Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial
Hospitalization in pregnancy and childbirth greatly increases the thromboembolic risk of these patients. The application of a protocol for assessing the risk of VTE reduces mortality and morbidity of these phenomena.
- Conditions
- Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications, Venous Thrombosis, Pulmonary Embolism
- Trial name
- NCT02600260
- Testing
- Enoxaparin, No intervention
- Where
- Brazil
- Volunteers
- 7,212 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Acute Coronary Syndrome, Myocardial Infarction
Cardiac Structure, Function, and Clinical Manifestations in MINOCA
The purpose of this study is to improve the differential diagnosis and clinical outcomes of acute coronary syndrome with non-obstructive coronary arteries, to investigate the relationship between the structural and functional…
- Trial name
- MINOCA (NCT03572023)
- Testing
- Integrative characterization of MINOCA patients, Characterization of MI patients with coronary obstruction
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
COVID-19, Hypercoagulability
Heparins for Thromboprophylaxis in COVID-19 Patients: HETHICO Study in Veneto
The HETHICO study aims to collect retrospectively documented clinical information on patients hospitalized in Veneto Region (Italy) for SARS-COVID-2 infection in 2 types of settings, medical environment (COORTE MED), and…
- Trial name
- HETHICO (NCT04393805)
- Testing
- Low Molecular Weight Heparin
- Where
- Italy
- Volunteers
- 744 people
- Sponsor
- Quovadis Associazione
Coagulopathy
COVID-19 Associated Coagulopathy in Egypt
Coagulopathy is one of the most significant prognostic factors in patients with COVID-19 and is associated with increased mortality and admission to critical care.
- Trial name
- NCT04507230
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Assiut University
Idiopathic SSNHL, Age Over 18
Blood Markers in Adult Patients With Sudden Sensorineural Hearing Loss (SSNHL)
The roles of thrombophilia and cardiovascular risk factors in sudden sensorineural hearing loss (SSNHL) remain controversial. Cochlear micro-thrombosis has been hypothesized as a possible pathogenic mechanism of SSNHL.
- Trial name
- SSNHL (NCT03919474)
- Testing
- microvascular markers
- Where
- France
- Volunteers
- 394 people
- Sponsor
- Hopital Lariboisière
Covid19, Hypercoagulable States Nec
Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a pandemic, which has affected approximately 4 lakhs individuals and claimed 16,362 deaths till now.
- Trial name
- COVID-19 (NCT04668404)
- Testing
- Sonoclot
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Covid19, Corona Virus Infection
Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events
An estimated 22% of the global population is at an increased risk of a severe form of COVID-19, while one in four coronavirus patients admitted to intensive care unit will develop a pulmonary embolism.
- Conditions
- Covid19, Corona Virus Infection, Thrombosis, ARDS
- Trial name
- iGenes-COVID19 (NCT04519398)
- Testing
- Complete thrombophilic profile testing by multiplex PCR
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Migraine, Thrombophilia
Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine
Acute Migraine attacks can be related to vascular or coagulation activation. Previous studies found relative high incidence of prothrombotic events in Migraine.
- Trial name
- NCT01905748
- Testing
- Laboratory tests
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- HaEmek Medical Center, Israel
Ovarian Hyperstimulation Syndrome, Hypercoagulability
Ovarian Hyperstimulation Syndrome in Patients Triggered by GnRH Agonist for Excessive Follicular Response
In the literature, the risk of moderate to severe OHSS is 3 to 6% and reaches 31% in high risk populations 9 days after oocyte triggering with hCG.
- Trial name
- COAGO (NCT02701452)
- Testing
- COAGO
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Birth Rate, Embryo Implantation
EFFects of Thrombophilia on the Outcomes of Assisted Reproduction Technologies
Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle…
- Conditions
- Birth Rate, Embryo Implantation, Reproductive Techniques, Thrombophilia
- Trial name
- NCT02407730
- Where
- Italy
- Volunteers
- 687 people
- Sponsor
- G. d'Annunzio University
Pregnancy, Obesity
Detecting Hypercoagulability in Morbidly Obese and Non Obese Parturients Following Cesarean Section Delivery
Investigators hypothesized that the impact of surgery in terms of inducing a hypercoagulable state is more evident in morbidly obese pregnant women as opposed to their non-obese counterparts.
- Conditions
- Pregnancy, Obesity, Hypercoagulability
- Trial name
- NCT02718924
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Corniche Hospital
Healthy Blood Donors, Moli-sani Subjects
Hypercoagulation Screening in Cancer
There is a complex, mutual relationship between cancer and thrombosis. Indeed, the tumor has the capacity to activate the hemostatic system and this leads to an increased thrombotic risk in cancer patients.
- Conditions
- Healthy Blood Donors, Moli-sani Subjects, Cancer Patients
- Trial name
- HYPERCAN (NCT02622815)
- Where
- 8 sites in Italy
- Volunteers
- 16,000 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Contraception, Hypercoagulability
Comparison of Coagulation Profiles Between Zoely and Minidoz: RCT
The purpose of this study is to compare the effects of Zoely® and Minidoz® on hemostatic profiles
- Trial name
- NCT03531437
- Testing
- 1.5 mg estradiol and 2.5 mg nomegestrol acetate, 15 µg ethinylestradiol and 60 µg gestodene
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Thrombophilia
Thrombin Generation and Gestational Outcome
In total 120 pregnant women's with history of recurrent miscarriages, are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant.
- Trial name
- NCT02139670
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- HaEmek Medical Center, Israel
Thrombophilia
A Comparison of Sequential Compression Devices and Foot Pumps in the Obstetric Population
The researchers at Johns Hopkins University believe that the foot pump will be superior to sequential compression devices in comfort and patient compliance which may increase provider efforts to prevent deep vein thrombosis (DVT)…
- Trial name
- NCT00356434
- Testing
- Kendall A-V foot impulse pump, model 6060, Kendall sequential compression device, model 9525
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Abnormalities, Blood Coagulation Disorder
Study of Abnormal Blood Clotting in Children With Stroke
Effective treatment and prevention strategies for childhood stroke and porencephaly can only be developed once the causes are understood.
- Conditions
- Abnormalities, Blood Coagulation Disorder, Brain Disease, Cerebrovascular Accident
- Trial name
- NCT00001927
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pseudotumor Cerebri, Cystinosis
The Role of Susceptibility to Thrombosis in the Pseudotumor Cerebri of Nephropathic Cystinosis: A Case-Control Study
This study will examine whether the tendency to have thrombosis, or the formation of blood clots inside blood vessels, has a role in the development of pseudotumor cerebri (PTC).
- Trial name
- NCT00071903
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Venous Thromboembolism
Frankfurt Thrombophilia Registry
Consecutive patients with acute or previous venous thromboembolism are enrolled in this registry. Using a standardized questionnaire, clinical data detailing venous thromboembolism and contributing VTE risk factors are recorded.
- Trial name
- NCT00683397
- Testing
- Blood sampling
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
Antiphospholipid Syndrome, Thrombophilia Due to Antiphospholipid Antibody
Effect of HCQ on AnxA5 Resistance Assay in Antiphospholipid (aPL) Positive Patients With and Without Systemic Lupus Erythematosus (SLE)
This 12 week study will observe patients with and without systemic lupus erythematosus who have persistent antiphospholipid antibodies in the blood who are starting a medicine called hydroxychloroquine.
- Conditions
- Antiphospholipid Syndrome, Thrombophilia Due to Antiphospholipid Antibody, Systemic Lupus Erythematosus
- Trial name
- NCT01475149
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Hospital for Special Surgery, New York