Clinical trials: Thrombosis
Venous Thrombosis
JETi Lower Extremity Venous Thrombosis
The JETi Registry is a prospective, single-arm, multicenter study to collect real-world data on the safety, performance, and clinical benefits of the JETi System for the treatment of acute and subacute thrombosis in the…
- Trial name
- JETiRegistry (NCT07027878)
- Testing
- JETi lower extremity venous thrombosis
- Where
- 30 sites in United States, Australia and 2 more
- Volunteers
- 121 people
- Sponsor
- Abbott Medical Devices
Splanchnic Vein Thrombosis
Evaluation of Safety and Efficacy of Anticoagulation Treatment in Patients With Splanchnic Vein Thrombosis: SAPIENT Study
Prospective single-centre, observational study with medical products. Patients with a medical history of SVT will be observed for at least 24 months after inclusion.
- Trial name
- SAPIENT (NCT06262750)
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Left Ventricular Thrombosis
Apixaban Versus Warfarin in Patients With Left Ventricular Thrombus
The purpose of this study is to compare the novel oral anticoagulant apixaban with the standard therapy of warfarin on the size reduction or resolution of left ventricular thrombus over 3 months.
- Trial name
- NCT02982590
- Testing
- Apixaban 5 MG Oral Tablet [ELIQUIS], Warfarin Sodium
- Where
- Malaysia
- Volunteers
- 27 people
- Sponsor
- Universiti Sains Malaysia
Venous Thromboembolism
Thromboprophylaxis in Critically Ill Patients
Intensive care patients are at high risk to develop deep venous thrombosis and pulmonary embolism. Despite anticoagulation with heparin 7% of ICU patients suffer from this serious complication.
- Trial name
- NCT00437697
- Testing
- dalteparin
- Where
- Austria
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement
Dual AntiPlatelet Therapies for Prevention of Periinterventional Embolic Events in TAVI
TAVI is increasingly adopted as standard treatment for many subgroups of patients with aortic stenosis. However, due to a lack of data there is yet no TAVI-specific guidance regarding the optimum periinterventional drug regimen.
- Conditions
- Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement, Intracranial Embolism
- Trial name
- DAPT-TAVI (NCT03001960)
- Testing
- Preloading before TAVI, Postloading after TAVI
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Hepatocellular Carcinoma (HCC)
Immune Checkpoint Inhibitors and Anti-vascular Endothelial Growth Factor Antibody/Tyrosine Kinase Inhibitors With or Without HAIC for Unresectable HCC With Portal Vein Tumor Thrombosis
Anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors (VEGF/TKI-ICI) plus Immune checkpoint inhibitors (ICIs) are recommended for patients with unresectable hepatocellular carcinoma (HCC) with PVTT in China.
- Trial name
- NCT06881433
- Where
- China
- Volunteers
- 1,649 people
- Sponsor
- Zhongda Hospital
Myocardial Infarction, Occlusive Thrombus
Thrombus Aspiration for OcLuded Coronary Artery Enhanced With Distal Injection Of Abciximab
Aims: (to prove that) The distal injection of IIb IIIa platelet receptor blocker to the thrombus occlusion is better than normal injection during primary percutaneous intervention (PCI) for the treatment of acute myocardial…
- Trial name
- TOLEDO1 (NCT01383785)
- Testing
- Intracoronary direct injection, Intracoronary and distal injection by aspiration device, Intracoronary distal injection by aspiration catheter device
- Where
- Spain
- Volunteers
- 186 people
- Sponsor
- Hospital Virgen de la Salud
Venous Thromboembolism
A Study in Europe Based on Medical Records That Looks at the Safety of Dabigatran in Children Below 2 Years of Age Who Have Had a Blood Clot and Are at Risk of Developing Another Blood Clot
The study is designed to collect and evaluate Dabigatran Etexilate (DE) safety in the context of routine anticoagulation care provided in the European Union (EU)/European Economic Area (EEA) for children under 2 years of age.
- Trial name
- DaPaR (NCT05536791)
- Testing
- Dabigatran Etexilate (DE)
- Where
- 6 sites in Germany, Netherlands and 2 more
- Sponsor
- Boehringer Ingelheim
Venous Thromboembolism, Cancer
Rivaroxaban in the Treatment of Venous Thromboembolism (VTE) in Cancer Patients
The purpose of this study is to show feasibility (efficacy and safety) of Rivaroxaban in the treatment of VTE in cancer patients in comparison to the standard treatment with low molecular weight heparin (LMWH).
- Trial name
- NCT02583191
- Testing
- Rivaroxaban, low-molecular heparine
- Where
- Germany
- Volunteers
- 246 people
- Sponsor
- AIO-Studien-gGmbH
Pancreatic Cancer, Thromboembolism
Gemcitabine With or Without Dalteparin in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00462852
- Testing
- dalteparin, gemcitabine hydrochloride, diagnostic laboratory biomarker analysis
- Where
- 8 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Acute Cardiac Syndrome, Stent Thrombosis
REsponsiveness to CLOpidogrel and Stent-related Events in Acute Coronary Syndromes (RECLOSE 2 - ACS)
The main objective of the project is to assess the long-term prognostic impact of residual platelet reactivity after optimal antiplatelet therapy in a large cohort of patients with acute coronary syndrome undergoing invasive…
- Conditions
- Acute Cardiac Syndrome, Stent Thrombosis, Platelet Function, Antiplatelet Therapy
- Trial name
- RECLOSE2-ACS (NCT01231035)
- Where
- Italy
- Volunteers
- 1,789 people
- Sponsor
- Careggi Hospital
Acute Myocardial Infarction
POST-dilatation to Improve Outcomes in Acute STEMI Patients Undergoing Primary With OCT Assessment
To evaluate the effective and safety of post-dilatation in patients with acute ST segment elevated myocardial infarction undergoing primary percutaneous intervention after thrombus aspiration assessed by optical coherence…
- Trial name
- POST-STEMI (NCT02121223)
- Testing
- post-dilatation with a Quantum Maverick balloon, manual thrombus aspiration + Promus Element stent implant
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Venous Malformation, Low Flow, Venous Malformations
Acetylsalicylic Acid Versus Placebo as an add-on Treatment to Local Non-steroidal Anti-inflammatory Drug for the Management of Thrombotic Episodes in Superficial Venous Malformations in Children Aged 6 to 17 Years.
Superficial venous malformations (SVMs) are rare congenital anomalies that present as bluish masses. These masses may be focal, with limited skin involvement, or segmental, with more extensive involvement.
- Trial name
- ASPIRIN (NCT07663825)
- Testing
- AAS at anti-inflammatory doses from 3 days to 14 days., Application of Diclofenac gel 1% twice a day
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Tours
Heparin-Induced Thrombocytopenia
The HIT-TRAP Trial
Randomised, double blind trial in non-intensive care trauma patients comparing unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) in heparin-induced thrombocytopenia (HIT).
- Trial name
- NCT00196417
- Testing
- Standard heparin (UFH) versus certoparin (LMWH)
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University Medicine Greifswald
End Stage Renal Failure on Dialysis, Complication of Dialysis
A Prospective Study of Airless Tubing in an Inpatient Acute Hemodialysis Unit in Hospitalized Patients
The introduction of unfractionated heparin (UFH), which prevents clotting of the extracorporal circuit, was one of the key advances that led to the rapid development and expansion of hemodialysis services.
- Conditions
- End Stage Renal Failure on Dialysis, Complication of Dialysis, Blood Coagulation Disorders
- Trial name
- NCT02086682
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Marie Hogan
Post Thrombotic Syndrome
Angioplasty-stenting vs Optimal Medical Treatment on Post-thrombotic Syndrome Reduction
The project will highlight the potential benefit of endovascular therapy on post thrombotic syndrome reduction after proximal iliac DVT. There is actually not real standard of care for the treatment of this pathology.
- Trial name
- EndoPTS (NCT04250025)
- Testing
- 60 patients benefit from immediate venous angioplasty stenting plus medical treatment, i.e. elastic compression and anticoagulation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Anticoagulants; Circulating, Hemorrhagic Disorder
MEdication Counselling Models for Outpatient oRal antIcoaguLation
The goal of this clinical trial is to investigate whether telepharmacy-led counselling can improve medication adherence, knowledge, and hospitalisation/mortality compared with pharmacist-led counselling in adult outpatients…
- Trial name
- MEMORIAL (NCT06290440)
- Testing
- Telepharmacy-led counselling, Pharmacist-led counselling
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Gia Dinh People Hospital
Cerebral Venous Sinus Thrombosis
The Dedicated Venous Sinus Thrombectomy Stent for Endovascular Treatment of Cerebral Venous Sinus Thrombosis.
A prospective, single-center, open-label,randomized, controlled,non-inferiority clinical trial will be conducted to evaluate the safety and efficacy of a dedicated venous sinus thrombectomy stent for endovascular treatment of…
- Trial name
- NCT05291585
- Testing
- the dedicated venous sinus thrombectomy stent, balloon catheter thrombectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ji Xunming,MD,PhD
Branch Retinal Vein Occlusion
601 Versus Ranibizumab in Patients With Branch Retinal Vein Occlusion (BRVO)
To evaluate the safety and efficacy of intravitreal recombinant humanized anti-VEGF monoclonal antibody in patients with visual impairment due to macular edema secondary to BRVO
- Trial name
- NCT04667897
- Testing
- 601 1.25mg, Ranibizuman 0.5 mg
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Aorta Aneurysm
Graft Thrombosis After Endovascular Aortic Repair - a Single Center Experience With the Cook Zenith Alpha Spiral-Z®
The purpose of this study is to assess the extent of thrombosis in the Zenith Alpha Spiral-Z® stent graft.
- Trial name
- NCT04564560
- Testing
- Endovascular aortic repair with Zenith Alpha Spiral-Z®
- Where
- Norway
- Volunteers
- 161 people
- Sponsor
- St. Olavs Hospital