Clinical trials: Thyroid Cancer Patients
Melanoma, Non-small Sell Lung Cancer (NSCLC)
Phase I/II Study of PDR001 in Patients With Advanced Malignancies
The purpose of this "first-in-human" study of PDR001 was to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of PDR001 administered i.v.
- Conditions
- Melanoma, Non-small Sell Lung Cancer (NSCLC), Triple Negative Breast Cancer, Anaplastic Thyroid Cancer
- Trial name
- NCT02404441
- Testing
- PDR001
- Where
- 41 sites in United States, Canada and 12 more
- Volunteers
- 319 people
- Sponsor
- Novartis Pharmaceuticals
Thyroid Cancer
Focus on Values to Stimulate Shared Decisions
Most patients with non-medullary thyroid carcinoma (TC) achieve remission after primary treatment. Nonetheless, 30% develop recurrent disease and/or distant metastases resulting in worse survival.
- Trial name
- NCT03905369
- Testing
- Decision aid and SDM booster, Deliberation training
- Where
- 11 sites in Netherlands
- Volunteers
- 128 people
- Sponsor
- Radboud University Medical Center
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Head and Neck Cancer
Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer
RATIONALE: Combretastatin A4 phosphate may stop the growth of anaplastic thyroid cancer by stopping blood flow to the tumor. PURPOSE: This phase II trial is studying how well combretastatin A4 phosphate works in treating patients…
- Trial name
- NCT00060242
- Testing
- fosbretabulin disodium
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Thyroid Carcinoma, Thyroid Papillary Carcinoma
Malignancy Predictors, Bethesda and TI-RADS Scores Correlated With Final Histopathology in Thyroid Diseases
In the last decades, thyroid cancer incidence has continuously increased all over the world, almost exclusively due to a sharp rise in the incidence of the papillary histologic subtype, which has the highest incidence of…
- Conditions
- Thyroid Carcinoma, Thyroid Papillary Carcinoma, Multinodular Goiter, Adolescent, Solitary Thyroid Nodule
- Trial name
- NCT04411290
- Testing
- Total thyroidectomy (TT)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Umraniye Education and Research Hospital
Thyroid Cancer, Active Surveillance
Patients With a Single, Small (2 cm or Less) Cancer Nodule in the Thyroid Gland Will be Offered Active Surveillance Initially for 5 Years. In Case of Cancer Growth or Changes in Ultrasonographic Appearance, Further Treatment Will be Offered.
Patients with a single, small (less than 2 cm) cancer nodule in the thyroid gland will be offered active surveillance initially for 5 years.
- Trial name
- NCT07822217
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Anaplastic Thyroid Cancers
A Trial of Adalimumab Combined to Chemotherapy and Radiotherapy in Patients With Anaplastic Thyroid Cancers
The hypothesis is that the particular richness of ATC's microenvironment in TAMs creates a unique opportunity for using Tumor Necrosis Factor blockade during chemotherapy and radiotherapy in order to counteract tumor resistance…
- Trial name
- TAM-RT (NCT02516774)
- Testing
- Adalimumab
- Where
- France
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Thyroid Gland Anaplastic Carcinoma
Intensity-Modulated Radiation Therapy and Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Anaplastic Thyroid Cancer
This randomized phase II trial studies the side effects and how well intensity-modulated radiation therapy (IMRT) and paclitaxel with or without pazopanib hydrochloride works in treating patients with anaplastic thyroid cancer.
- Trial name
- NCT01236547
- Testing
- Intensity-Modulated Radiation Therapy, Paclitaxel, Pazopanib Hydrochloride
- Where
- 130 sites in United States
- Volunteers
- 123 people
- Sponsor
- National Cancer Institute (NCI)
Head and Neck Cancer, Head and Neck Neoplasms
Cell-free Tumor DNA in Head and Neck Cancer Patients
This study investigates if head and neck squamous cell carcinoma can be tracked with cell-free tumor DNA, RNA or HPV-DNA, in blood samples from patients referred with suspicion of cancer, and if it can be used in detecting…
- Conditions
- Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer
- Trial name
- NCT03942380
- Testing
- Liquid biopsy
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Christian von Buchwald
Thyroid Cancer
UPCC 36315 A Phase II Study Of Everolimus (RAD001) And Lenvatinib (E7080) In Patients With Metastatic Differentiated Thyroid Cancer Who Have Progressed on Lenvatinib Alone
This is a Phase 2 Study of Everolimus and Lenvatinib in patients with metastatic differentiated thyroid cancer who have progressed on lenvatinib alone. Patient will have imaging, lab test and physical exams
- Trial name
- NCT03139747
- Testing
- Lenvatinib, Everolimus
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Thomas Jefferson University
Malignant Neoplasm of Bone and Articular Cartilage, Malignant Neoplasms of Female Genital Organs
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this clinical research study is to find the highest tolerable dose of gemcitabine that can be given by…
- Conditions
- Malignant Neoplasm of Bone and Articular Cartilage, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Independent (Primary) Multiple Sites, Malignant Neoplasms of Lip Oral Cavity and Pharynx
- Trial name
- NCT03093909
- Testing
- Gemcitabine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Carcinoma, Nonmedullary
Effects of Radioactive Iodine on the Immune System in Thyroid Cancer
Blood will be drawn 1 month before and 2 month after regular radioactive iodine treatment. Monocytes will be isolated. The three main outcomes are whole blood counts, cytokine production upon in vitro stimulation of monocytes and…
- Trial name
- SCIMITAR (NCT05989555)
- Testing
- Blood drawing
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Radiofrequency Ablation in Treating Patients Who Are Undergoing Surgery for Thyroid Cancer
RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Ultrasound-guided radiofrequency ablation may be effective treatment for thyroid cancer.
- Trial name
- NCT00103155
- Testing
- conventional surgery, radiofrequency ablation
- Where
- United States
- Sponsor
- University of California, San Francisco
Medullary Thyroid Cancer
Prospective Study Evaluating the Medullary Thyroid Cancer Management's Care Using PET F-DOPA in Patients With a High Level of Postoperative Residual Thyrocalcitonin
The aim of the trial is to study a radiating diagnosis agent used in post surgery when the biological assessment highlighted a residual disease.
- Trial name
- CMTpostopFDOPA (NCT02856347)
- Testing
- 18F-DOPA
- Where
- 5 sites in France
- Volunteers
- 24 people
- Sponsor
- Institut Claudius Regaud
Medullary Thyroid Carcinoma
ImmunoTEP for Patients With Medullary Thyroid Carcinoma.
The aim of this study is to optimize pretargeting parameters using pharmacokinetic and imaging data for immuno-PET using anti-CEA x anti-HSG TF2 BsMAb and 150 MBq of 68Ga-IMP-288 peptide in MTC patients with abnormal Ct serum…
- Trial name
- iTEP-CMT (NCT01730638)
- Testing
- • TF2 and 68 Ga-IMP-288
- Where
- 3 sites in France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Thyroid Cancer, Tyrosine Kinase Inhibitor
HRQOL in Locally Advanced Thyroid Carcinoma
The purpose of this study was to explore the changes of health-related quality of life (HRQOL) in patients with locally advanced thyroid cancer (LATC) receiving TKI drugs (anlotinib, lenvatinib, etc.).
- Conditions
- Thyroid Cancer, Tyrosine Kinase Inhibitor, Health Related Quality of Life
- Trial name
- LATCQOL (NCT05824312)
- Testing
- Tyrosine kinase inhibitor drugs.
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fujian Cancer Hospital
Hypothyroidism; Irradiation
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
To offer the possibility of a treatment that could achieve a meaningful reduction in the incidence of post-radiation therapy hypothyroidism.
- Trial name
- WIN-HYPO2021 (NCT05316922)
- Testing
- Levothyroxine
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Thyroid Cancer
Psycho-oncological Intervention Through Counselling in Patients With Differentiated Thyroid Cancer in Treatment With Radioiodine
Diagnosis and treatment of differentiated thyroid carcinomas cause anxiety and depression. Additionally, these patients suffer hormonal alterations, associated with psychological symptoms (changes in mood, emotional instability…
- Trial name
- COUNTHY (NCT05054634)
- Testing
- Psycho-oncological Intervention Based on Counselling (PIBC)
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Quironsalud
Thyroid Cancer
The Effects of Preoperative Prayer on Postoperative Quality of Recovery in Patients Undergoing Thyroidectomy
physiological end-point, incidence of adverse events, and changes in psychological status. In the past, physiological goals, major morbidity and mortality were used as indicators of recovery after surgery.
- Trial name
- NCT03375931
- Testing
- Prayer, non-prayer
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Yonsei University
Differentiated Thyroid Cancer
A Phase 3 Study of Donafenib in Patients With Radioiodine-refractory Differentiated Thyroid Cancer
This is a multicenter, randomized, double-blind, placebo-controlled Phase 3 study to compare the progression free survival, overall response rate (ORR) and safety of participants treated with Donafenib 0.3g Bid by continuous oral…
- Trial name
- DTC (NCT03602495)
- Testing
- Donafenib
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd