Clinical trials: Thyroid Diseases
B Thalassemia
Thyroid Function , HbA1c in Relation to Ferritin Level in Adullt Patient e B Thalassemia
to evaluate thyroid function ,HbA1C,\&lipid profile in thalassemic patient to correlate thyroid function , Hba1c , lipid profile e ferritin level in thalassemic patient
- Trial name
- NCT06377865
- Volunteers
- 72 people
- Sponsor
- Assiut University
Congenital Hypothyroidism, L-Thyroxine
Diagnosis and Follow-up of Patients With Subclinical Hypothyroidism
Long term follow-up of the patients with delayed TSH elevation or subclinical hypothyroidism has been seldom reported. The purpose of this study was to explore the diagnostic criteria for subclinical hypothyroidism and the…
- Conditions
- Congenital Hypothyroidism, L-Thyroxine, Follow-Up
- Trial name
- CHRO1 (NCT00497575)
- Sponsor
- Zhejiang University
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Therapeutic Procedural Complication
Compare a New Method and Formula as a Guide for the Intubation of a Left-sided Double-lumen Tube
One-lung ventilation (OLV) is required for the most of thoracic surgery to facilitate surgical visualization by collapsing the lung. The double-lumen tube (DLT) is the commonly used device for OLV.
- Trial name
- NCT03545737
- Testing
- Measurement, Formula
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Superior Laryngeal Nerve Block
Ultrasound-guided Thyroid Cartilage Plane Block for Awake Intubation
The goal of this clinical trial is to investigate the clinical effectiveness and safety of superior laryngeal nerve block through surface injection of local anesthetic solution on the thyroid cartilage in patients undergoing…
- Trial name
- NCT06065475
- Testing
- Ultrasound-guided bilateral Thyroid Cartilage Plane Block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma
Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery
This phase II trial studies how well sunitinib malate works in treating patients with thyroid cancer that did not respond to iodine I 131 (radioactive iodine) and cannot be removed by surgery.
- Conditions
- Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma, Stage III Thyroid Gland Follicular Carcinoma AJCC v7
- Trial name
- NCT00381641
- Testing
- Laboratory Biomarker Analysis, Pharmacogenomic Study, Sunitinib
- Where
- 17 sites in United States
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
Atypical Parkinsonism, Dementia With Lewy Bodies
Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism
The goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism.
- Conditions
- Atypical Parkinsonism, Dementia With Lewy Bodies, Multiple System Atrophy, MSA
- Trial name
- FUSAP (NCT06204575)
- Testing
- Data collection
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rambam Health Care Campus
Iodine Deficiency
Seaweed Iodine Delivered Via Food or Supplementation
In this project, the investigators propose an intervention design testing the efficacy of a food reformulated with seaweed as an ingredient in meal, capsules against placebo and no intervention controls.
- Trial name
- INNOVATE (NCT04875377)
- Testing
- Reformulated pizza, Control pizza, Seaweed capsule
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Differentiated Thyroid Cancer
Efficacy of Apatinib in Radioactive Iodine-refractory Differentiated Thyroid Cancer
Radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) is a great challenge in the treatment of thyroid cancer. Tyrosine kinase inhibitors (TKIs), like sorafenib and lenvatinib which have been approved by food and…
- Trial name
- NCT03048877
- Testing
- Apatinib Oral Tablet
- Where
- 2 sites in China
- Volunteers
- 118 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Neoplasms
Study of Anlotinib Hydrochloride Capsules in the Treatment of Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma
The study aims to observe and investigate the efficacy and safety of Anlotinib capsules in patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid carcinoma in the real world, and to summarize…
- Trial name
- NCT05994365
- Testing
- Anlotinib Hydrochloride Capsule
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Rrelapsed Graves' Disease
A Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Relapsed Graves' Disease
To evaluate the short-term efficiency and safety of HIFU treatment in the relapsed Graves' disease.
- Trial name
- HIFURGD (NCT02685514)
- Testing
- HIFU Graves
- Where
- Hong Kong
- Volunteers
- 22 people
- Sponsor
- The University of Hong Kong
Stage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer
Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer
This phase II trial studies how well thyroid gland removal with or without central lymph node dissection works in treating patients with thyroid cancer or suspected thyroid cancer that has not spread to the lymph nodes…
- Conditions
- Stage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer, Stage III Papillary Thyroid Cancer
- Trial name
- NCT02138214
- Testing
- Thyroidectomy, entral lymph node dissection (CLND), Quality-of-life assessment
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Wisconsin, Madison
Thyroid Nodule
Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules
Shear wave ultrasound elastography is a new technique of finding the softness or hardness in tissue by applying a "push" generated by the machine.
- Trial name
- NCT01757834
- Testing
- SWUS Elastography
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Washington
Thyroid Cancer
Efficacy of Radium 223 in Radioactive Iodine Refractory Bone Metastases From Differentiated Thyroid Cancer
The purpose of this Phase II single-arm study is to evaluate the efficacy of Radium-223 in treating bone lesions from differentiated thyroid cancer that are I-131 refractory.
- Trial name
- RAD-THYR (NCT02390934)
- Testing
- Radium 223
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Low Risk Differentiated Thyroid Cancer
Shared Care Thyroid Cancer Follow-up Utilizing Thyroid Cancer Assessment Reminder System (TCARS) Study - A Pilot Study.
This study aims to assess the feasibility of a shared-care model for low-risk differentiated thyroid cancer (DTC) patients, primary care practitioners (PCPs) and the tertiary care center utilizing a digital health-based thyroid…
- Trial name
- NCT05510934
- Testing
- Shared-care model
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Nova Scotia Health Authority
Hypocalcemia
Early Prediction of Hypocalcaemia Following Thyroid Surgery
150 patients divided into two groups.The experimental group was submitted at the assay of iPTH six hours after surgery whilst the control group was submitted to a daily assay of serum calcium and phosphorus.
- Trial name
- NCT02853721
- Testing
- iPTH, no dosage of iPTH
- Volunteers
- 150 people
- Sponsor
- University of Cagliari
DTC - Differentiated Thyroid Cancer
A Phase I Trial of Af-001 in Patients With Differentiated Thyroid Cancer
This trial consists of 2 parts, i.e., Part Ia and Ib. The Part Ia is to evaluate the safety and tolerability of a single intravenous dose of af-001 in patients with radically unresectable, recurrent, metastatic differentiated…
- Trial name
- NCT07287748
- Testing
- [211At]NaAt
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Alpha Fusion Inc.
Thyroid Diseases, Surgery
NerveTrend vs. i-IONM in Prevention of Recurrent Laryngeal Nerve Events During Bilateral Thyroid Surgery.
The aim of this study is to compare two distinct modes of NIM Vital application in thyroid surgery: i-IONM vs. NerveTrend mode with respect to prevalence of early postoperative RLN injury.
- Conditions
- Thyroid Diseases, Surgery, Recurrent Laryngeal Nerve Injuries
- Trial name
- NCT04794257
- Testing
- Neuromonitoring of the recurrent laryngeal nerves
- Where
- Poland
- Volunteers
- 264 people
- Sponsor
- Marcin Barczynski
Thyroid Cancers
Safety and Efficacy of Transoral Robotic Thyroidectomy Versus Traditional Open Thyroidectomy for Thyroid Cancer
In general, the utilization of the transoral vestibular approach in robotic surgery demonstrates efficacy comparable to that of traditional open surgery in the treatment of thyroid cancer.
- Trial name
- NCT06958601
- Testing
- surgical procedure
- Where
- China
- Volunteers
- 430 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Head and Neck Cancer
Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00100828
- Testing
- irinotecan hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins