Clinical trials: Thyroid Disorders
Thyroid Nodule
Comparison of Anesthesia Effects of Sevoflurane and Propofol Combined With Dexmedetomidine in Intraoperative Neuromonitoring During Thyroidectomy
According to the previous studies, it is reported that the use of sevoflurane in the maintenance of anesthesia may lead to delayed occurrence of positive electromyographic (EMG) signal and lower obtained signal amplitude.
- Trial name
- NCT04680650
- Testing
- Anesthesia was maintained with sevoflurane, Anesthesia was maintained with propofol
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Anaplastic Thyroid Cancer, Insular Thyroid Cancer
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer
This phase I trial is studying the side effects of gefitinib in treating patients with metastatic or unresectable head and neck cancer or non-small cell lung cancer.
- Conditions
- Anaplastic Thyroid Cancer, Insular Thyroid Cancer, Metastatic Parathyroid Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
- Trial name
- NCT00068497
- Testing
- gefitinib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Medullary Thyroid Cancer, Recurrent Thyroid Gland Medullary Carcinoma
GFRα4 CAR T Cells in MTC Patients
This is an open-label phase 1 study to assess the safety and feasibility of autologous T cells expressing a single-chain scFv targeting GFRα4 with tandem TCR/CD3ζ and 4-1BB (TCRζ/4-1BB) co-stimulatory domains (referred to as…
- Trial name
- NCT04877613
- Testing
- single dose of CART-GFRa4 cells, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Head and Neck Cancer
High Dose vs Low Dose I 131 +/- rhTSH for Differentiated Thyroid Cancer
RATIONALE: Radioactive iodine uses radiation to kill tumor cells. Giving iodine I 131 with or without thyroid-stimulating hormone after surgery may kill any tumor cells that remain after surgery.
- Trial name
- HiLo (NCT00415233)
- Testing
- recombinant thyroid-stimulating hormone, Radiodine ablation without rhTSH
- Where
- 25 sites in United Kingdom
- Volunteers
- 438 people
- Sponsor
- University College, London
Subacute Thyroiditis, SARS CoV 2 Infection
Subacute Thyroiditis in the SARS-CoV-2 Era
Many cases of subacute thyroiditis (SAT) have been described related to SARS-CoV-2 infection, but no prospective data about follow-up is known.
- Conditions
- Subacute Thyroiditis, SARS CoV 2 Infection, Thyrotoxicosis
- Trial name
- SAT-COVID-19 (NCT06391515)
- Testing
- Blood sample, CRF, thyroid ultrasound
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- University of Modena and Reggio Emilia
Hypothyroidism; Surgery, Head and Neck Cancer
Wound Complications in Head and Neck Surgery
This is a prospective observational study evaluating wound complications following head and neck surgery. Patients undergoing major head and neck surgery will be included in the study.
- Conditions
- Hypothyroidism; Surgery, Head and Neck Cancer, Wound Heal, Laryngeal Cancer
- Trial name
- NCT03134976
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Cardiovascular Diseases, Coronary Disease
Immunogenetic Factors of Coronary Heart Disease
To assess the association of immunogenetic factors with onset of coronary heart disease and the interrelationship of these factors with standard coronary heart disease risk factors.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005184
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lymph Node Dissection, Lymph Node Metastases
Significance of Contralateral Central Lymph Node Dissection in Unilateral cN0 Differentiated Thyroid Carcinoma.
There are so many contradictions over central lymph node dissection in unilateral cN0(Clinically N0) differentiated thyroid carcinoma.In order to provides a new theoretical basis for the operation of central lymph node in…
- Conditions
- Lymph Node Dissection, Lymph Node Metastases, Differentiated Thyroid Carcinoma
- Trial name
- NCT03845647
- Testing
- contralateral central lymph node dissection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Healthy
Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone
The purpose of this study is to correlate in an elderly population (≥ 65 years), the different levels of serum TSH, with cardiopulmonary capacity, quality of life, depressive symptoms and cognition.
- Trial name
- NCT01849861
- Testing
- Methimazole
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Thyroid Diseases
Contribution of ICG Angiography in the Detection of Parathyroids and the Prevention of Hypoparathyroidism Post Total Thyroidectomy
Hypoparathyroidism is the most common complication after a total thyroidectomy surgery. It becomes permanent after 6 months. Untreated permanent hypoparathyroidism is a source of numerous complications in general and therefore…
- Trial name
- HYPOCAAVI (NCT04785443)
- Testing
- ICG, Control group
- Where
- France
- Volunteers
- 242 people
- Sponsor
- University Hospital, Brest
Autoimmune Hyperthyroidism, Children
Autoimmune Hyperthyroidism in Prepubertal Children
The investigators propose a multicenter retrospective study to assess clinical, biochemical, and auxological characteristics at diagnosis and during follow-up in a cohort of Caucasian pediatric patients diagnosed with autoimmune…
- Trial name
- IPER6 (NCT07544290)
- Testing
- restrospective observational study
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Ospedale San Raffaele
Hypothyroidism
Clinical Efficacy of Darqeen Capsule for the Management of Hypothyroidism Associated with Female Reproductive Hormonal Imbalance
STUDY OBJECTIVES 1. To assess the safety of Darqeen capsule for the management of Hypothyroidism 2. Evaluate the efficacy of Darqeen capsule for the management of Hypothyroidism 3.
- Trial name
- NCT06826248
- Testing
- Darqeen Capsule
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Hamdard University
Papillary Thyroid Cancer
Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
- Trial name
- NCT06733740
- Testing
- ultrasound-guided thermal ablation
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Nausea and Vomiting
Impact of Drains on Postoperative Nausea and Vomiting After Thyroid Surgery
Wound Drains after Thyroid- and Parathyroid Surgery Impact on Postoperative Nausea and Vomiting (PONV)
- Trial name
- PONTS (NCT01679418)
- Testing
- Placement of a wound drain post surgery (Redon; Medicoplast), No-drain after surgery
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Kantonsspital Liestal
Sexuality, Thyroid
Dysthyroidism and Female Sexual Function
The aim of the study is to evaluate the incidence of sexual dysfunction in presence of dysthyroidism and the impact of restoring euthyroidism on female sexual function
- Trial name
- NCT03093285
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Florence
Thyroid Cancer
Clinical Evaluation of Genetron TERT/BRAF PCR Kit in Thyroid Cancer Patients
The purpose of this trail is to evaluate the performance of Genetron TERT/BRAF PCR Kit in Thyriod Cancer patients using real-time PCR method.
- Trial name
- NCT05395429
- Where
- 4 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Genetron Health
Thyroid Cancer, Hypoparathyroidism
Study on Application of Suturing Parathyroid Markers in Thyroid Cancer Surgery
To study the protective effect of suture parathyroid marker method on the function of parathyroid gland in thyroid cancer surgery
- Conditions
- Thyroid Cancer, Hypoparathyroidism, Marker; Structural, Complication of Surgical Procedure
- Trial name
- NCT03514251
- Testing
- The suture marks the location of the parathyroid gland
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Bo Wang,MD
Tocilizumab, Thyroid Associated Ophthalmopathy
Efficacy and Safety of Tocilizumab for TAO
This study aims to evaluate the efficacy and safety of tocilizumab treating Thyroid Associated Ophthalmopathy.
- Trial name
- NCT06087731
- Testing
- Tocilizumab
- Where
- China
- Sponsor
- Sun Yat-sen University
Locally Advanced or Metastatic Medullary Thyroid Cancer, Medullary Thyroid Cancer
Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment
The purpose of this study is to evaluate the effect of patient outreach program on the proportion of time patients with MTC experience moderate or severe AEs during first 12 months of treatment with vandetanib
- Trial name
- NCT01298323
- Testing
- Patient outreach, Vandetanib
- Where
- 66 sites in Australia, Austria and 18 more
- Volunteers
- 205 people
- Sponsor
- Sanofi
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