Clinical trials: Thyroid Disorders
Thyroid, Genetic Predisposition to Disease
PheWAS of a Polygenic Predictor of Thyroid Function
Performing a phenome-wide association study (PheWAS) identifying clinical diagnoses associated with a polygenic predictor of Thyroid stimulating hormone (TSH) levels identified by a previously published genome-wide association…
- Trial name
- PHETHYR (NCT03597659)
- Testing
- phenome-wide association study (PheWAS)
- Where
- France
- Volunteers
- 37,154 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Thyroid Carcinoma, Hypothyroidism
The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
The purpose of this study is to evaluate whether taking thyroid hormone medication with beverages other than water, decreases absorption of the medication by the intestine.
- Trial name
- NCT01707056
- Testing
- Black Coffee, Coffee with Milk, Black Tea
- Where
- 3 sites in United States
- Sponsor
- Medstar Health Research Institute
Graves Disease, Graves Disease (Basedow's Disease)
Prophylactic Treatment of Graves Ophthalmopathy (GO) in Newly Diagnosed Graves' Disease (GD) With Atorvastatin (ATORGO)
Graves' disease is an autoimmune condition that causes an overactive thyroid. Some people with Graves' disease develop thyroid eye disease, also called Graves' orbitopathy, which can cause swelling around the eyes, eye…
- Conditions
- Graves Disease, Graves Disease (Basedow's Disease), Graves Orbitopathy, Graves Ophthalmopathy
- Trial name
- ATORGO (NCT07883356)
- Testing
- Atorvastatin
- Where
- 7 sites in Sweden
- Volunteers
- 554 people
- Sponsor
- Region Skane
Hypothyroidism, Exophthalmos
The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions
Iodine 131 (131I） treatment on Graves disease and Graves ophthalmopathy relationship has always been the focus of debate. Majority view is that the current treatment does not increase 131I Graves ophthalmopathy, therefore,Graves…
- Trial name
- NCT01204359
- Testing
- Iodine 131
- Where
- 2 sites in China
- Volunteers
- 627 people
- Sponsor
- Sun Yat-sen University
Thyroid Disease, Parathyroid Disease
Antimicrobial Prophylaxis in Thyroid and Parathyroid Surgery
The effectiveness of antimicrobial prophylaxis (AMP) for prevention of surgical site infection (SSI) following thyroid and parathyroid surgery remains uncertain.
- Trial name
- Ito-RCT1 (NCT01805856)
- Testing
- PIPC piperacillin sodium, CEZ, cefazolin sodium
- Where
- Japan
- Volunteers
- 2,164 people
- Sponsor
- Ito Hospital
Hypothyroidism
Maternal Hypothyroidism in Pregnancy
There is general agreement that thyroid gland function should be assessed in pregnant women. When the gland produces too little thyroid hormone (hypothyroidism), all of the woman's bodily functions slow down, and there are…
- Trial name
- NCT00818896
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Benign Thyroid Nodule
Percutaneous Thermo-ablation for the Treatment of Benign Thyroid Nodules
The goal of this observational study is to learn if radiofrequency ablation (RFA), a minimally invasive thermoablation technique, can safely reduce symptoms and improve quality of life in adults with symptomatic benign thyroid…
- Trial name
- BIRRO-TA (NCT07237373)
- Testing
- Percutaneous radiofrequency ablation
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Papillary Thyroid Cancer
Papillary Thyroid Cancer and Central Lymp Node Dissection
Papillary cancer is a disease that spreads through lymphatic ways and its treatment is surgery. We performed prophylactic central dissection in addition to bilateral total thyroidectomy in patients with bethesda 5 and bethesda 6…
- Trial name
- NCT05873283
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Thyroid Cancer
An Easy Sonographic Scoring System for Predicting Malignant Thyroid Nodules
The purpose of the investigators study is to retrospectively evaluate the predictors of malignant thyroid nodules and established an useful scoring system based on sonographic findings and demographic data.
- Trial name
- NCT01307761
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Far Eastern Memorial Hospital
Liver Cirrhosis
Thyroid Function in Liver Cirrhosis: Is it Affected?
In patient with liver cirrhosis ,thyroid functions are largely affected in our study we studied the changes in thyroid functions in patients with liver cirrhosis
- Trial name
- NCT05250401
- Testing
- liver functions and thyroid functions
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Mansoura University
Thyroid Cancer, RAI-Refractory Thyroid Cancer
I-124 PET/CT Imaging and Dosimetry for RAI-Naïve or Refractory Thyroid Cancer
The objective of this study is to demonstrate the clinical utility of I-124 PET/CT imaging and dosimetry in patients with thyroid cancer including 1) Evaluation of extent (volume and pattern) of remnant tissue in post total…
- Trial name
- NCT06443866
- Testing
- Disease status detection, Theranostic dosimetry, I-124 PET/CT imaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Miami Cancer Research Center, Inc.
Thyroid Cancer
Endoscopic Thyroidectomy Versus Open Thyroidectomy for Papillary Thyroid Carcinoma
Recently, endoscopic thyroidectomy using gasless unilateral transaxillary approach has been proven feasible and safe in several Chinese medical centers.
- Trial name
- NCT05446441
- Testing
- Endoscopic surgery;
- Volunteers
- 634 people
- Sponsor
- Zhejiang Provincial People's Hospital
Colorectal Cancer Not MSI-H or MMR-deficient, GIST
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors
Assessment of the efficacy and safety of Regorafenib and Avelumab in patients with advanced or metastatic solid tumors (ten cohorts), once the Recommanded Phase II Dose (RP2D) has been determined (phase I trial).
- Conditions
- Colorectal Cancer Not MSI-H or MMR-deficient, GIST, Oesophageal or Gastric Carcinoma, Biliary Tract Cancer
- Trial name
- REGOMUNE (NCT03475953)
- Testing
- Phase 1 : Regorafenib, Phase 1 : Avelumab, Phase 2 : Regorafenib
- Where
- 7 sites in France
- Volunteers
- 747 people
- Sponsor
- Institut Bergonié
Obesity
Effects of Exercise on Thyroid Stimulating Hormone Among Class-I Obese Patients With Diabetes Mellitus and Lipid Disorders
Obesity is characterized by an excessive accumulation of body fat that gives rise to significant comorbidities, such as diabetes, hypertension, dyslipidemia, cardiovascular disease, and many cancers.
- Trial name
- NCT06119737
- Testing
- Exercise
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Ziauddin University
Thyroid Gland Follicular Carcinoma, Thyroid Gland Papillary Carcinoma
Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors
This clinical trial evaluates the impact of a patient-centered health and wellness coaching (HWC) intervention on adherence to treatment plans and healthy lifestyle practices in patients with papillary or follicular thyroid…
- Trial name
- NCT07545837
- Testing
- Counseling, Interview, Questionnaire Administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Thyroid Cancer, Goiter
Superficial Cervical Plexus Block With Dexmedetomidine Versus Without Adjuvant in Thyroid Surgery
Efficacy of Superficial Cervical Plexus Block (SCPB) with Dexmedetomidine Adjuvant Compared to Without Adjuvant in Thyroid Surgery.
- Conditions
- Thyroid Cancer, Goiter, Hyperthyroidism
- Trial name
- BPSS-DEX (NCT07274670)
- Testing
- Dexmedetomidine & Bupivacaine., Bupivacain
- Where
- Indonesia
- Volunteers
- 58 people
- Sponsor
- Udayana University
Breast Cancer, Esophageal Cancer
Brodalumab in the Treatment of Immune-Related Adverse Events
The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy.
- Conditions
- Breast Cancer, Esophageal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT06673329
- Testing
- Brodalumab, CT scan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brian Henick, MD
Thyroid, Goiter
Subtotal Versus Total Thyroidectomy for Graves' Disease
The extent of thyroid resection in Graves' disease remains controversial. The aim of this study was to evaluate long-term results of bilateral subtotal thyroidectomy versus total thyroidectomy in patients with Graves'…
- Trial name
- NCT01408368
- Testing
- Bilateral subtotal thyroidectomy, Total thyroidectomy
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Vitamin D Deficiency, Iodine Deficiency
Vitamin D, Iodine, and Lead Levels in Haitian Infants and Children.
Vitamin D deficiency is common worldwide, including in infants and children, and rickets remains a public health concern in many developing countries.
- Conditions
- Vitamin D Deficiency, Iodine Deficiency, Hypothyroidism, Rickets
- Trial name
- Haiti (NCT02301520)
- Where
- 2 sites in Haiti
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
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