Clinical trials: Thyroid Disorders
Thyroid Cancer
To Compare The Effects Of Two Doses Of Vandetanib In Patients With Advanced Medullary Thyroid Cancer
The purpose of this study is to give patients with medullary thyroid cancer either 300mg/day or 150mg/day vandetanib and compare how well each dose affects how their cancer responds.
- Trial name
- NCT01496313
- Testing
- 300mg vandetanib, 150mg vandetanib
- Where
- 30 sites in United States, Czechia and 7 more
- Volunteers
- 81 people
- Sponsor
- Sanofi
Thyroid Carcinoma
Prospective, Non-interventional, Post-authorization Safety Study That Includes All Patients Diagnosed as Unresectable Differentiated Thyroid Carcinoma and Treated With Sorafenib
This is a non-interventional, multi center post-authorization safety study that includes all patients diagnosed as Unresectable Differentiated Thyroid Carcinoma (DTC) and treated with Sorafenib within a certain period.
- Trial name
- JPMS-DTC (NCT02185560)
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- Japan
- Volunteers
- 453 people
- Sponsor
- Bayer
Breast Cancer, Cancer
IIT2020-20-SHIRAZIP-WALK: Nature Walks
The purpose of this study is to examine whether nature-based activities provide benefits for breast cancer survivors. The investigators want to know whether a nature-based exercise program is feasible.
- Conditions
- Breast Cancer, Cancer, Lymphoma, Leukemia
- Trial name
- NCT04896580
- Testing
- Nature based exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Hypothyroidism
Effect of Exercise on Irisin Levels of Hypothyroid Rats
The aim of study was to evaluate the role of exercise on serum irisin levels in hypothyroid rats.
- Trial name
- NCT06699069
- Testing
- Control or Euthyroid group, Hypothyroid group, Hypothyroid group received exercise
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Autoimmune Thyroiditis
Oxidative Status in Children With Autoimmune Thyroiditis
Oxidative status in autoimmune thyroiditis was not investigated previously in children and adolescents. We investigated oxidant and antioxidant systems in a cohort of Egyptian children and adolescents with AIT to explore their…
- Trial name
- NCT02318160
- Testing
- measurement of oxidant status in AIT
- Volunteers
- 64 people
- Sponsor
- Assiut University
Total Thyroidectomy, Bilateral Neck Exploration for Primary Hyperparathyroidism
Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery
Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low…
- Trial name
- NCT02089542
- Testing
- MB and fluorescent imaging
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia
Thyroid Cancer
Influencing Factors and Prediction Model of False-negative Central Lymph Nodes in Thyroid Cancer Patients
The problem of false-negative lymph nodes in the central region (CLN) refers to the inability to detect lymph nodes (LN) metastasis during preoperative ultrasound examination but is confirmed by surgical and postoperative…
- Trial name
- NCT06423105
- Volunteers
- 6,369 people
- Sponsor
- Ningning Ren
Thymectomy, Thyroid Cancer
Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid
Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy +…
- Trial name
- NCT07274605
- Testing
- Total thyroidectomy, Extended isthmusectomy
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thyroid Disease, Hashimoto's Thyroiditis
ThyMoves: Screening and Exercise to Improve Muscle, Enhance Quality of Life, and Reduce Fall Risk in Thyroid Disease
Objectives: This study aims to assess health-related quality of life (QoL) in adults with thyroid hormone disorders and identify modifiable factors to improve QoL in patients with Hashimoto's thyroiditis (HT) and multinodular…
- Conditions
- Thyroid Disease, Hashimoto's Thyroiditis, Hyperthyreosis and Goiter, Hypothyroidism
- Trial name
- ThyMoves (NCT06960005)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Aalborg University Hospital
Nutritional Status, Nutrient Deficiency
Adults Nutrition as a Protective or Health-risk Factor
To obtain up-to-date data on nutrient intakes in adults, a national dietary survey - the EU Menu study will be conducted during 12 consecutive months in 2017/2018, providing data on the consumption of foods and enabling the…
- Conditions
- Nutritional Status, Nutrient Deficiency, Micronutrient Deficiency, Vitamin D Deficiency
- Trial name
- NUTRIHEALTH (NCT03284840)
- Testing
- Assessement of nutritional status, Thyroid size
- Where
- 3 sites in Slovenia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Hypothyroidism, Hypertension
The Effect of SPU on Hormonal and Cardiometabolic Factors
The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.
- Conditions
- Hypothyroidism, Hypertension, Healthy Adult, Diabete Mellitus
- Trial name
- NCT07688824
- Testing
- Soleus pushup exercise
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Patients After Thyroid Surgery
Structured Active Follow-up in Postoperative Management of Thyroid
Patients after thyroid cancer surgery face multiple challenges, including recurrence monitoring, medication adjustment, complication management (e.g., hypoparathyroidism, vocal cord dysfunction), and long-term psychosocial…
- Trial name
- NCT07589660
- Testing
- Structured Active Follow-up
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Yu Feng
Differentiated Thyroid Cancer
Pembrolizumab in High-risk Thyroid Cancer
This window of opportunity trial is studying a checkpoint inhibitor agent to treat differentiated thyroid cancer in a neoadjuvant setting. A checkpoint inhibitor is a compound aimed at restoring tumor immunosurveillance.
- Trial name
- NePenThe (NCT05852223)
- Testing
- Pembrolizumab
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Thyroid Cancer, Thyroid Nodule
Modified Cormack Lehane Scores Evaluated by Laryngoscopy During Awake Versus Under General Anesthesia
Nowadays, 5-step modified Cormack-Lehane scoring (MCL) system is frequently used in the observation of laryngeal structures by direct laryngoscopy.
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Adenoma
- Trial name
- NCT03826680
- Testing
- Flexible fiberoptic laryngoscopy, Direct laryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Carcinoma, Papillary, Follicular
Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve During Thyroid Surgery
The paralysis of the external branch of superior laryngeal nerves after thyroid surgery is known to be a common complication resulting in poor quality of life.
- Trial name
- NCT03773120
- Testing
- Using Neuromonitoring to find EBSLN
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Sepsis
Thyroid and Cortisol Hormone Response to Sepsis
Thyroid and cortisol hormone response to sepsis
- Trial name
- NCT06289179
- Volunteers
- 114 people
- Sponsor
- Assiut University
Recurrent Thyroid Cancer
Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
The goal of this study is to evaluate combined radioactive iodine (RAI, 131-I) and external beam radiotherapy (XRT) to optimize the radiation dose delivered to treat well differentiated thyroid cancers (DTC) with iodine-avid…
- Trial name
- NCT04892303
- Testing
- Combination treatment (CXRPT) of external beam radiation (XRT) plus radioactive iodine (RAI)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Goiter
Changes in Quality of Life Following Surgical Treatment of Benign Non-toxic Goiter
The aim is to investigate the influence of surgical treatment on benign non-toxic goiter on the disease specific quality of life evaluated 6 months after thyroid surgery. All investigations follow already scheduled treatments.
- Trial name
- SOLOIST (NCT02651818)
- Testing
- Thyroidectomy
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- University of Southern Denmark
Different Regimens in Treatment of Hypothyroidism During Fasting in Ramadan
Comparison Between Variable Time Regimen of Dosing L-Thyroxine for Treatment Hypothyroid Fasting Ramadan
This is a study aiming to report the effect of a variable time regimen of L T4 during Ramadan, as an easier alternative, on adherence and thyroid status after Ramadan compared to standard daily dosing.
- Trial name
- NCT05918497
- Where
- Egypt
- Volunteers
- 89 people
- Sponsor
- Sohag University
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