Clinical trials: Thyroid Disorders
Thyroid Cancer, Thyroid Nodule
Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Thyroid Malignancy
Thyroid surgery is the most common surgical procedure among endocrine surgeries. It is performed in patients with suspected malignancy, patients diagnosed with malignancy, and for toxic nodular goiter [1].
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Diseases, Delta Neutrophyl Index
- Trial name
- NCT04425512
- Testing
- Complete Blood Count
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Secondary Hypothyroidism
Recovery Rate in Secondary Hypothyroidism
The aim of this project is to assess the rate of recovery of secondary hypothyroidism in patients with pituitary disorders.
- Trial name
- NCT05276856
- Testing
- Levothyroxine
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Nova Scotia Health Authority
Cognitive Impairment
Cognitive Functions During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma
Thyroid carcinoma is the common endocrine system malignant neoplasm. At present it has become the malignant neoplasm of fastest growing incidence rate. More than 90% thyroid carcinoma is thyroid differentiated carcinoma（DTC）.
- Trial name
- NCT02665325
- Testing
- TSH-suppressive therapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Cancer, Tumor, Solid
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced…
- Conditions
- Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
- Trial name
- NCT05620134
- Testing
- JK08, Pembrolizumab, Lenvatinib Pill
- Where
- 11 sites in Belgium, Spain
- Volunteers
- 263 people
- Sponsor
- Salubris Biotherapeutics Inc
Hypothyroidism
The Impact of Subclinical Hypothyroidism on Cardiovascular System
This research aims to evaluate the relation between SCH and cardiovascular System by assessment of lipid profile and carotid intima-media thickness (CIMT), as a marker of atherosclerosis, and endothelial function.
- Trial name
- NCT04236232
- Testing
- Thyroid function
- Volunteers
- 100 people
- Sponsor
- Assiut University
Thyroid Cancer
Anlotinib or Penpulimab in Combination With RAI for DTC
The purpose of this study is to assess the efficacy and safety of anlotinib in combination with I-131 in locally advanced/metastatic differentiated thyroid cancer.
- Trial name
- NCT04952493
- Testing
- Anlotinib hydrochloride, Sodium Iodide I 131, Penpulimab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital
Neoadjuvant Treatment, Thyroid Cancer
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
To look at the effectiveness of zanzalintinib, followed by surgery, in treating advanced thyroid cancer. The safety of this treatment will also be studied.
- Trial name
- NCT06959511
- Testing
- Zanzalintinib
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Papillary Thyroid Carcinoma, Thyroid Neoplasms
RET-US Study - Ultrasound-Based Prediction of RET Alterations and Lateral-Neck Metastasis in Thyroid Cancer
Why is this study being done? RET gene alterations occur in only 5-10 % of papillary thyroid cancers, but they can change how surgeons treat the disease.
- Conditions
- Papillary Thyroid Carcinoma, Thyroid Neoplasms, RET Proto-Oncogene Mutation, Lymphatic Metastasis
- Trial name
- RET-US (NCT07042984)
- Testing
- AI-Ultrasound RET Prediction
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Fujian Medical University
Graves Disease (Basedow's Disease)
Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance
The aim of our study is to compare in a randomized multicentric study the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation (experimental arm) compared to a conventional approach based on the…
- Trial name
- NCT01295333
- Testing
- the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation, The initiation of LT4 as soon as the first biological signs of hypothyroidism.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Graves' Disease
Thyroid Disease and Personality Study
Observe the relationship between thyroid function and personality traits
- Trial name
- TPS (NCT02620085)
- Testing
- blood sampling
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Congenital Hypothyroidism
Role of Next Generation Sequencing in the Etiological Diagnosis of Permanent Congenital Hypothyroidism With in Situ Thyroid
Retro-prospective, exploratory, single-centre observational study conducted at the Endrocrine-Metabolic Diseases Centre of the Pediatrics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
- Trial name
- NCT06728735
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Papillary Thyroid Cancer, Papillary Thyroid Carcinoma
Clinical Utility of Preoperative Thyroid GuidePx® Testing
The purpose of this study is to learn whether having Thyroid GuidePx® test results available before treatment may help patients with papillary thyroid cancer and doctors make better-informed treatment decisions.
- Trial name
- NCT07584447
- Volunteers
- 85 people
- Sponsor
- University of Calgary
Healthy Volunteers
Thyroid and Fat Tissue Metabolism
This study will use a technique called microperfusion to examine how thyroid hormones are involved in fat metabolism. The thyroid gland produces two kinds of hormones: T3 and T4.
- Trial name
- NCT00312715
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Thyroid Nodules, Thyroid Abnormalities
A Novel Ultrasound Probe for Thyroid Imaging and Machine Learning
The objective of the THYMAL 01 pilot study is to evaluate the Sound Blade Imaging System in subjects with benign thyroid nodules undergoing standard-of-care ultrasound imaging.
- Trial name
- THYMAL 01 (NCT07488585)
- Testing
- Thyroid ultrasound
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sound Blade Medical Inc.
Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia Type 2
Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients
Background: Medullary thyroid carcinoma (MTC) is a rare malignancy, occurring either as a sporadic disease (75% of cases), or in a hereditary pattern as multiple endocrine neoplasia (MEN) type 2 (MEN2A or MEN2B) or familial…
- Trial name
- NCT01424878
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer, Thyroid Neoplasms
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
IoN is a phase II/III trial that will look to ascertain whether or not radio-iodine ablation is necessary for low risk differentiated thyroid cancer patients.
- Trial name
- IoN (NCT01398085)
- Testing
- I131 1.1 GBq, No Radioactive iodine (No-RAI) ablation
- Where
- 36 sites in United Kingdom
- Volunteers
- 504 people
- Sponsor
- University College, London
Differentiated Thyroid Cancer
PET-guided External Beam Radiotherapy in Differentiated Thyroid Cancer
Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.
- Trial name
- NCT03191643
- Volunteers
- 16 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Thyroid Nodule
Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules
This is a prospective trial to evaluate the effects of laser ablation on symptomatic benign thyroid nodules. The study is designed to assess the clinical efficacy, safety, tolerability and impact on symptoms of single ultrasound…
- Trial name
- NCT04277455
- Testing
- Laser ablation of benign thyroid nodule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johnson Thomas
Recurrent Malignant Solid Neoplasm, Recurrent Melanoma
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cabozantinib S-malate in treating younger patients with solid tumors that have come back or no longer respond to treatment.
- Conditions
- Recurrent Malignant Solid Neoplasm, Recurrent Melanoma, Recurrent Primary Central Nervous System Neoplasm, Recurrent Thyroid Gland Carcinoma
- Trial name
- NCT01709435
- Testing
- Cabozantinib S-malate, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 23 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Goiter, Nodular
LISA-study : Levothyroxin in Nodular Goiter
Primary objective: To evaluate change in total volume of all nodules. Secondary objectives: To evaluate change in goiter volume after a 12-months treatment, number of nodules and echogenicity of nodules.
- Trial name
- NCT00277589
- Testing
- Levothyroxin-Na, Levothyroxine-Na + iodide, Iodide
- Where
- Germany
- Volunteers
- 1,024 people
- Sponsor
- Sanofi
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