Clinical trials: Thyroid Eye Disease
Thyroid Eye Disease
The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED)
This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED: 1. β- Carotene (30 mg) 2. Vit C (100 mg) 3. Vit E (Alpha-Tocopherol Acetate): 60-200 IU 4.
- Trial name
- NCT02393183
- Testing
- ASTED, Selenium
- Where
- Iran
- Sponsor
- Iran University of Medical Sciences
Thyroid Eye Disease
Development of an AI Solution to Evaluate Clinical Activity of TAO Using Periocular Images Taken by Smartphones in Patients With Thyroid Dysfunction
This study was conducted to develop an AI solution to evaluate clinical activity score (CAS) of thyroid associated orbitopathy (TAO) using periocular selfie images taken by smartphones in patients with thyroid dysfunction.
- Trial name
- NCT05731154
- Testing
- taking periorbital selfie images using smartphones
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Thyroid Eye Disease
Customized Multiple Orbital Wall Decompression for Sight-threatening Graves's Ophthalmopathy
Graves' orbitopathy (GO) is an disfiguring and disabling autoimmune condition. Sight-threatening GO is an most severe form and occurs in about 5% of patients with Graves' disease.
- Trial name
- NCT05627401
- Testing
- Modified multiple orbital wall decompression
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Thyroid Eye Disease, Eyelid Diseases
Tamsulosin for Thyroid Lid Retraction
The purpose of this study is to examine the effect of using Tamsulosin for treatment of eyelid retraction as part of thyroid eye disease.
- Trial name
- NCT04359979
- Testing
- Tamsulosin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Thyroid Eye Disease
AS-OCT of the Cornea in Thyroid Diseases
use the anterior segment optical coherence tomography (AS-OCT) to evaluate the tear meniscus parameters, total corneal thickness (CT), and epithelial thickness in active and inactive thyroid eye diseases (TED) patients and…
- Trial name
- NCT05241626
- Testing
- AS-OCT
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Thyroid Eye Disease
The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease
ASTED (Antioxidant Supplements for TED) trial is an investigator-initiated, randomized, triple masked, clinical trial of a selected combination of vitamins and minerals versus placebo in patients with moderate to severe thyroid…
- Trial name
- NCT02422368
- Testing
- Methylprednisolone + ASTED
- Where
- 2 sites in Iran
- Sponsor
- Iran University of Medical Sciences
Graves Ophthalmopathy, Graves Disease
Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy
The aim of this study is to evaluate the effects of subantimicrobial dose doxycycline (50 mg/d), administered for 12 weeks, on patients with mild Thyroid-Associated Ophthalmopathy (TAO).
- Conditions
- Graves Ophthalmopathy, Graves Disease, Thyroid-associated Ophthalmopathy, Thyroid Diseases
- Trial name
- NCT02203682
- Testing
- Doxycycline hyclate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Thyroid Eye Disease
Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease
Thyroid eye disease (TED) is an autoimmune disease that affects the eye area. The disease presents with a variety of physical findings, including bulging of the eyes (proptosis), upper and lower eyelid retraction, and…
- Trial name
- HALR (NCT01738243)
- Testing
- Hyaluronic Acid Gel injection, Saline injection
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of California, Los Angeles
Thyroid Eye Disease
Celecoxib for Thyroid Eye Disease
Thyroid eye disease (TED) is an autoimmune disorder in which the immune system attacks orbital tissues, resulting in characteristic changes in eyelid position, globe position in the orbit, extraocular muscle balance, and optic…
- Trial name
- NCT02845336
- Testing
- Celecoxib, artificial tears
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Keratoconus, Corneal Ectasia
Corneal Tomographic Parameters in TGD
The current study involved analysis of the corneal tomographic parameters of patients with thyroid gland dysfunction (hyperthyroidism or hypothyroidism), including those with an autoimmune etiology, in comparison to healthy…
- Conditions
- Keratoconus, Corneal Ectasia, Thyroid Eye Disease
- Trial name
- NCT04433936
- Testing
- Pentacam tomography
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ameera Gamal Abdelhameed
Thyroid Related Eye Disease
Psychological Status and Related Factors of Thyroid Related Eye Disease
The purpose of this study is to evaluate the psychological status of Thyroid Related Eye Disease.
- Trial name
- NCT03426696
- Testing
- psychological condition
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huijing Ye
Thyroid Eye Disease
B-cell Depletion Therapy With Rituximab for Thyroid Eye Disease
Thyroid eye disease (TED) is an autoimmune inflammation of the orbital tissues that develops in up to 50% of patients with Graves' disease.
- Trial name
- BetTeRTED (NCT02316691)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pittsburgh
Thyroid Eye Disease
The Therapeutic Effect of Dysthyroid Optic Neuropathy
Thyroid associated ophthalmopathy (TAO) is a common autoimmune disorder. The pathogenesis of TAO is unclear, and studies found that T cell, B cell and monocytes, macrophages and mast cells are located in the orbital tissue of…
- Trial name
- NCT04096612
- Testing
- Orbital decompression combined with MPT
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Thyroid Eye Disease, Ocular Hypertension
The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.
The purpose of this study is to evaluate the potential secondary beneficial effect of prostaglandin analogues (PA) treatment in thyroid eye disease (TED) patients.
- Conditions
- Thyroid Eye Disease, Ocular Hypertension, Glaucoma
- Trial name
- NCT01927406
- Testing
- Prostaglandin Analog, Timolol
- Where
- United States
- Sponsor
- Stanford University
Thyroid Eye Disease
Disappearance of Graves' Orbitopathy
There is a general belief among physicians involved with Graves' orbitopathy (GO) that this syndrome is somehow "chronic", namely that the patient's eyes do not return the way they were before GO appeared.
- Trial name
- DISGO (NCT03103607)
- Testing
- Ophthalmological evaluation, Questionnaire
- Volunteers
- 99 people
- Sponsor
- University of Pisa
Thyroid Eye Disease
Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease
Patients with Thyroid Eye Disease (TED) often have enlarged extraocular muscles and higher orbital fat contents due to their disease process.
- Trial name
- NCT01798966
- Testing
- SENSIMED Triggerfish
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sensimed AG
Thyroid Associated Ophthalmopathies, Graves´ Ophthalmopathy
Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease)
The purpose is to investigate tocilizumab administration in patients with moderately to severely or sight-threatening GO (Graves' ophthalmopathy) without response to treatment with corticoid intravenous pulses.
- Conditions
- Thyroid Associated Ophthalmopathies, Graves´ Ophthalmopathy, Thyroid Eye Disease
- Trial name
- GRC (NCT01297699)
- Testing
- Tocilizumab (RoActemra®), Sterile 0.9% Sodium Chloride
- Where
- 9 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Carcinomas, Amyloidosis
B-Receptor Signaling in Cardiomyopathy
We hope to determine the importance of different genes (including B receptors) in anthracycline-induced cardiomyopathy. This has important benefits to patients exposed to anthracyclines, as this could help determine whether…
- Conditions
- Carcinomas, Amyloidosis, Anal Cancer, Anemia
- Trial name
- NCT01135849
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Daniel Bernstein
Thyroid-Related Eye Disease
Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED)
This is a pilot study to determine the safety and efficacy of orbital injections of LIPO-102.
- Trial name
- NCT00954057
- Testing
- LIPO-102
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 11 people
- Sponsor
- Neothetics, Inc
Graves Ophthalmopathy, Graves Disease
Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy
The aim of this study is to evaluate the effects of subantimicrobial dose doxycycline (50 mg/d), administered for 12 wk, for patients with active moderate-severe Graves' Orbitopathy (GO).
- Conditions
- Graves Ophthalmopathy, Graves Disease, Eye Diseases, Thyroid Diseases
- Trial name
- NCT01727973
- Testing
- Doxycycline
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Sun Yat-sen University