Clinical trials: Thyroid Goitre
Strabismus, Esotropia
Bupivacaine Injection of Eye Muscles to Treat Strabismus
This study seeks to determine if bupivacaine injection of eye muscles can make them stronger and stiffer, and thereby correct the position of eyes that are turned in or mis-aligned, a condition generally termed strabismus.
- Conditions
- Strabismus, Esotropia, Exotropia, Graves Disease
- Trial name
- NCT01616108
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Smith-Kettlewell Eye Research Institute
Graves Disease
Allogeneic Anti-CD19 CAR-T for Refractory Graves' Disease
Graves' disease is an autoimmune disease. The TSH receptor antibody(TRab) produced by B cells drives the production of thyroid hormone, which causes systemic disorders and thyroid eye disease.
- Trial name
- NCT07129642
- Testing
- Allogeneic CAR-T
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Zhongshan Hospital
Thyroid Eye Disease, Eyelid Diseases
Tamsulosin for Thyroid Lid Retraction
The purpose of this study is to examine the effect of using Tamsulosin for treatment of eyelid retraction as part of thyroid eye disease.
- Trial name
- NCT04359979
- Testing
- Tamsulosin
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Graves Disease, Relapse
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
In this study, the dose of methimazole was adjusted according to the different states of thyroid function, and the effects of conventional therapy and intensive therapy on the cumulative recurrence of Graves' hyperthyroidism…
- Conditions
- Graves Disease, Relapse, Treatment, Drug Withdrawal
- Trial name
- NCT05461820
- Testing
- Methimazole
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Hyperthyroidism, Graves Disease
Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism
Hyperthyroidism is the second most common endocrine disorder in the world with Graves' disease being the commonest. Anti thyroid drugs including methimazole, carbimazole, and propylthiouracil are effective treatments but take in…
- Trial name
- ChoPS (NCT03303053)
- Testing
- Cholestyramine Powder 4g, Prednisolone, Standard treatment
- Where
- 3 sites in Malaysia
- Volunteers
- 135 people
- Sponsor
- Clinical Research Centre, Malaysia
Thyroid Nodule
Levothyroxine Treatment in Thyroid Benign Nodular Goiter
We will study the effect of taking eltroxin at different time, i.e. fasting or postprandial periods. We will also study the effect of levothyroxin treatment in Chinese people
- Trial name
- NCT00552253
- Testing
- Levothyroxin treatment
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Graves' Disease
A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease
An open label study to evaluate the safety and efficacy of CFZ533 following 12 weeks treatment in patients with Graves' disease
- Trial name
- NCT02713256
- Testing
- CFZ533
- Where
- 3 sites in United States, Germany
- Volunteers
- 15 people
- Sponsor
- Novartis Pharmaceuticals
Thyroid Eye Disease
An Efficacy and Safety Study of NTB003 in Participants With Thyroid Eye Disease (TED)
Multicentre, Phase Ib/II Clinical Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of NTB003 in Participants with Thyroid Eye Disease
- Trial name
- NCT07462130
- Testing
- NTB003
- Volunteers
- 74 people
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
Graves' Disease
Comparative Study of Different I-131 Doses in Graves' Disease
Radioactive iodine (RAI) administration is an effective and completely established treatment modality in hyperthyroidism including Graves' disease.
- Trial name
- NCT02114619
- Testing
- Low dose of I-131, Intermediate dose, High dose
- Where
- Iran
- Volunteers
- 450 people
- Sponsor
- Mashhad University of Medical Sciences
Graves Disease
Efficacy of Methimazole Dosing Algorithm
To prospectively study the efficacy and safety of the Cook County Health (CCH) methimazole (MMI) dosing algorithm in the setting of new onset Graves' disease.
- Trial name
- NCT05964452
- Testing
- Methimazole Tablets
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cook County Health
Thyroid Goiter, Thyroid Nodule
Analgesia for Thyroidectomy Using Bilateral Superficial Cervical Plexus Block With Bupivacaine Only or Adding Ketorolac to it.
Thyroidectomy is considered a common operation with moderate to severe postoperative pain in some patients. Patients are divided into two groups.
- Trial name
- NCT05180214
- Testing
- Bupivacain, Ketorolac
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Sohag University
Graves Ophthalmopathy
Genetics and Epigenetics of Graves' Orbitopathy
Graves' orbitopathy (GO) is an autoimmune disease persisting when immunosuppression is achieved. Orbital fibroblasts from GO patients display peculiar phenotypes even if not exposed to autoimmunity, possibly reflecting genetic or…
- Trial name
- GeneGO (NCT04488406)
- Testing
- No Intervention
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- University of Pisa
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Thyroid Eye Disease
Exploring the Value of 18F-AlF-FAPI PET/CT in Assessing the Activity of Thyroid Eye Disease
FAPI PET has been developed as a promising approach for the evaluation of fibroinflammatory, such as in inflammatory bowel disease.
- Trial name
- NCT06359795
- Testing
- 18F-AlF-FAPI PET/CT, 99mTc-DTPA SPECT/CT
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Graves Disease
Course for Brain Fatigue After Graves' Disease Controlled Study
BACKGROUND. Mental fatigue (MF) is common in the most common form of hyperthyroidism, Graves' disease (GD). Clinically, MF is the primary mental symptom in patients with GD and is characterized by difficulties maintaining…
- Trial name
- MF-Course (NCT06134219)
- Testing
- MF course, Usual health care
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Vastra Gotaland Region
Thyroidectomy, Goiter
Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid Surgery
Despite use of meticulous surgical techniques and regardless of surgical access via conventional open or endoscopy, postoperative adhesions develop in the vast majority of patients undergoing neck surgery.
- Conditions
- Thyroidectomy, Goiter, Thyroid Cancer
- Trial name
- NCT05851560
- Testing
- Oxidized regenerated cellulose(ORC), Hyaluronic acid(HA)
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Thyroid Eye Disease
The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED)
This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED: 1. β- Carotene (30 mg) 2. Vit C (100 mg) 3. Vit E (Alpha-Tocopherol Acetate): 60-200 IU 4.
- Trial name
- NCT02393183
- Testing
- ASTED, Selenium
- Where
- Iran
- Sponsor
- Iran University of Medical Sciences
Thyroid Associated Ophthalmopathy
Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy
This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and…
- Trial name
- NCT07124572
- Testing
- Imaging and ocular examinations
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ocular Motility Disorders, Strabismus
Clinical Validation of AI-Based Quantitative Eye Movement Analysis From Smartphone 9-Gaze Videos (Glandy EOM)
This prospective, multicenter, multinational observational study evaluates the clinical validity of an AI-based quantitative eye movement analysis system (Glandy EOM) that analyzes smartphone-recorded 9-gaze videos.
- Conditions
- Ocular Motility Disorders, Strabismus, Extraocular Muscle Dysfunction, Thyroid Eye Disease
- Trial name
- GLANDY-EOM-VAL (NCT07623837)
- Testing
- Glandy EOM (AI-based quantitative eye movement analysis software)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- THYROSCOPE INC.
Thyroid Eye Disease (TED)
A Study of VV-14305 for the Treatment of Thyroid Eye Disease
The goal of this study is to evaluate the safety, tolerability, and efficacy of KRIYA-586 (VV-14305) in treating thyroid eye disease (TED).
- Trial name
- RECLAIM (NCT07404111)
- Testing
- VV-14305
- Where
- 5 sites in United States, New Zealand
- Volunteers
- 135 people
- Sponsor
- Kriya Therapeutics, Inc.