Clinical trials: Thyroid Hormones
Iodine Deficiency, Subclinical Hypothyroidism
Iodine Supplementation in Obesity
The study hypothesis is that iodine supplementation will lower serum TSH and leptin concentrations and thereby improve the lipid and glucose profile.
- Trial name
- NCT01985204
- Testing
- Iodine tablet
- Where
- 2 sites in Morocco
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Subclinical Hypothyroidism
Thyroid Hormone Replacement for Subclinical Hypothyroidism
Subclinical hypothyroidism (SCH) is a common condition among older men and women. Although by definition SCH comprises biochemically mild thyroid hormone deficiency without overt symptoms, it is a possible contributor to multiple…
- Trial name
- TRUST (NCT01660126)
- Testing
- Levothyroxine
- Where
- United Kingdom
- Volunteers
- 737 people
- Sponsor
- NHS Greater Glasgow and Clyde
Allan-Herndon-Dudley Syndrome
Thyroid Hormone Analog Therapy in MCT8 Deficiency: Triac Trial Patients
This therapeutical trial will be conducted in patients with the Allan-Herndon-Dudley Syndrome (AHDS), which is mutations in MCT8.
- Trial name
- NCT02060474
- Testing
- Triac
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Erasmus Medical Center
Breast Cancer
Brown Seaweed as a Breast Cancer Preventive
Japanese postmenopausal women in Japan have about one ninth the rate of American postmenopausal women. Rates of breast cancer double even after just ten years among Japanese women who migrate to the US.
- Trial name
- NCT01204957
- Testing
- Seaweed and Soy Protein
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Hyperthyroidism, Hypothyroidism
Natural History of Thyroid Function Disorders
Participants in this study will be patients diagnosed with or suspected to have a thyroid function disorder. These conditions may include: hypothyroidism, hyperthyroidism, thyroid hormone resistance, Graves' Dermopathy, and…
- Conditions
- Hyperthyroidism, Hypothyroidism, Grave's Disease
- Trial name
- NCT00001159
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Subclinical Hypothyroidism
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG).
- Trial name
- RepleniSH (NCT07380854)
- Testing
- levothyroxine
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Seoul National University Bundang Hospital
Thyroid Dysfunction, Atherosclerosis
The TRUST Trial - CardioVascular Imaging ECHO
Coronary heart disease (CHD) and heart failure (HF) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832960
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 185 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Atrial Fibrillation and Flutter, Hyperthyroidism
Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone Stabilization
Patients with hyperthyroidism or hypothyroidism are often combined with atrial fibrillation, but after the stabilization of thyroid hormone levels after treatment, the patients' atrial fibrillation still persists.
- Conditions
- Atrial Fibrillation and Flutter, Hyperthyroidism, Hypothyroidism
- Trial name
- SQUIRREL (NCT06452823)
- Testing
- Catheter Ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Second Affiliated Hospital of Jiaxing University
Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency
Rescue of Infants With MCT8 Deficiency
Monocarboxylate Transporter 8 (MCT8) deficiency (that is also known as Allan-Herndon-Dudley syndrome) is a rare X-linked inherited disorder of brain development that causes severe intellectual disability and problems with…
- Trial name
- DITPA (NCT04143295)
- Testing
- Diiodothyropropionic acid (DITPA)
- Where
- United States
- Sponsor
- Roy E. Weiss, M.D.
Thyroid Disease, Kidney Diseases, Chronic
A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication of chronic kidney disease that has been associated with impaired quality of life and cardiovascular complications.
- Trial name
- NCT03191188
- Testing
- Levothyroxine Sodium
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of California, Irvine
Chronic Kidney Disease on Hemodialysis, Thyroid Gland Disease
Interleukin-6 and Thyroid Dysfunction in Hemodialysis Patients
Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may…
- Trial name
- NCT07328113
- Testing
- Thyroid hormone
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Dr. Soetomo General Hospital
Thyroid Disorders, Thyroid Stimulating; Hormone, C
Harmonization of Thyroid-stimulating Hormone Immunoassays Reagents
Given the prevalence and gravity of thyroid disorders, timely diagnosis, initiation, and monitoring of therapy are important to restrict the impact of the disease on public health.
- Trial name
- IFCC-TSH (NCT05151120)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Postpartum Depression
Postpartum Thyroid Measures and Mood
Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.
- Trial name
- NCT00565032
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Infertility, Female
Association Between Serum Thyroid-stimulating Hormone (TSH) and Intracytoplasmic Sperm Injection (ICSI) Outcome in Women Undergoing ICSI
TSH has been suggested to be involved in reproductive challenges such as ovulatory issues, infertility, miscarriage, and maternal complications for many years.
- Trial name
- NCT07449260
- Testing
- Basal TSH level
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nonalcoholic Steatohepatitis (NASH)
Study to Evaluate the Safety, Tolerability, and Efficacy of ASC41 in Adults With NASH
This is a phase 2, randomized, double-blind, placebo controlled study in adults with biopsy confirmed NASH. The study is aimed at evaluating efficacy and tolerability of ASC41 in adults with NASH.
- Trial name
- NCT05118360
- Testing
- ASC41 2 mg, ASC41 4 mg
- Sponsor
- Gannex Pharma Co., Ltd.
Thyroid
Interrelations Between FT3, FT4 and Pituitary TSH
TSH plays a central role in current thyroid function testing both as a diagnostic tool and therapeutic target. Recent studies have suggested a more complex and hierarchical relationship between logTSH and FT4 over the entire…
- Trial name
- IIFHT (NCT01969552)
- Where
- Germany
- Volunteers
- 1,912 people
- Sponsor
- Klinikum Lüdenscheid
MSI-H Colorectal Cancer, Melanoma
Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors
This is an open-label, parallel group, non-randomized, multicenter phase II study to evaluate the efficacy of spartalizumab (cohorts 1 and 2) and tislelizumab (cohort 3) in monotherapy in patients with PD1-high-expressing tumors.
- Conditions
- MSI-H Colorectal Cancer, Melanoma, Anal Carcinoma, Mesothelioma
- Trial name
- ACROPOLI (NCT04802876)
- Testing
- Spartalizumab, Tislelizumab
- Where
- Spain
- Volunteers
- 184 people
- Sponsor
- SOLTI Breast Cancer Research Group
Attention Deficit Hyperactivity Disorder
Endocrine Disrupting Chemicals and Hormones in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Growth hormone and thyroid function are associated with both physical and neurocognitive development.
- Trial name
- ADHD (NCT04970303)
- Testing
- Methylphenidate
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Thyroid Cancer
Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer
To evaluate quality of life in patients after 10 days pause of thyroid medication (Liothyronine) compared to treatment with recombinant TSH (Thyrogen) before radioiodine uptake and treatment in a double-blinded, randomised…
- Trial name
- NCT00604318
- Testing
- rhTSH
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Copenhagen University Hospital at Herlev