Clinical trials: Thyroid Metabolism
Thyroid Nodule, Thyroid Dysfunction
Postoperative Hypocalcemia After Thyroidectomy
This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024).
- Conditions
- Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer
- Trial name
- NCT07428057
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Minia University
Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism
Hypothyroidism and Liver Fibrosis Severity in MASLD
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, characterized by excess fat accumulation in the liver associated with metabolic risk factors such as obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Hypothyroidism, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT07793279
- Volunteers
- 85 people
- Sponsor
- Assiut University
Hypothyroidism, Primary Hypothyroidism
Serum Adipokines and Metabolic Parameters With Hormone Replacement in Newly Diagnosed Hypothyroidism
Primary hypothyroidism is associated with significant metabolic disturbances, including dyslipidemia, insulin resistance, adipose tissue dysfunction, and altered adipokine secretion.
- Conditions
- Hypothyroidism, Primary Hypothyroidism, Metabolic Syndrome
- Trial name
- NCT07616570
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Hypothyroidism
Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer
1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy. 2.
- Trial name
- NCT01744769
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Konkuk University Medical Center
Hypothyroidism
Hypothyroidism, Metabolism and Food Intake
This project has the following primary aims: To measure changes in appetite and food intake in newly diagnosed hypothyroid patients during the first six months after starting levothyroxine (L-T4) substitution therapy Secondary…
- Trial name
- Hypomafia (NCT02993562)
- Testing
- Levothyroxine
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Herlev Hospital
Dyslipidemia, Subclinical hypothyroïdism
Thyroid Hormone Replacement for Subclinical Hypothyroidism and Dyslipidemia in ASCVD (ThyroHeart-Lipid Study)
In ASCVD patients complicated with subclinical hypothyroidism, the percentage of those who did not reach the target of lipid-lowering therapy (LDL-C>1.8mmol/L) is usually higher than that in population with normal thyroid…
- Conditions
- Dyslipidemia, Subclinical hypothyroïdism, Statin, ASCVD
- Trial name
- NCT03606824
- Testing
- Pitavastatin and levothyroxine
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Shaochun.Li
Hyperthyroidism
Effects of Hyperthyroidism on Amount and Activity of Brown Adipose Tissue
The investigators wish to evaluate the effect of thyroid hormones on brown adipose tissue in humans in an observational study on patients with thyrotoxicosis.
- Trial name
- NCT02133040
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Graves Disease
BASE-DIET: a Study on Nutritional Intervention in Patients With Graves' Disease
The goal of this clinical trial is to determine whether a structured dietary-nutritional intervention can prevent excessive weight regain and improve body composition and lifestyle habits in adults recently diagnosed with Graves'…
- Trial name
- BASEDIET (NCT06921304)
- Testing
- Intensive Lifestyle Intervention
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Non-Alcoholic Fatty Liver Disease
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Non Alcoholic Fatty Liver Disease Patients
A double-blind placebo controlled randomized Phase 3 study to evaluate the safety and tolerability of once-daily, oral administration of 80 or 100 mg resmetirom versus matching placebo.
- Trial name
- MAESTRO-NAFLD1 (NCT04197479)
- Testing
- Resmetirom
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 1,343 people
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Congenital Hypothyroidism, Metabolic Syndrome
Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism
We propose a multicenter prospective study to define the prevalence and severity score of metabolic syndrome in a prepubertal pediatric cohort with congenital hypothyroidism, compared to a healthy and normal-weight pediatric…
- Trial name
- IpoMet (NCT07126353)
- Testing
- prospective observational study (clinical, hormonal and auxological data)
- Where
- Italy
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Buzzi Children's Hospital
Pregnancy, Thyroid Function Tests
Maternal Thyroid Function in Early Pregnancy and Their Relationship With Gestational Diabetes Mellitus
This study was conducted to analyze the role of TSH level and TPOAb status in early pregnancy and use this information in assessment of the risk of gestational diabetes mellitus at different weeks of gestation when the FT4 level…
- Conditions
- Pregnancy, Thyroid Function Tests, Gestational Diabetes Mellitus
- Trial name
- NCT02555332
- Testing
- 75g oral glucose tolerance test (OGTT)
- Volunteers
- 7,729 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Hypocalcemia, Thyroid Diseases
Does Preoperative Calcium and Calcitriol Decrease Rates of Post Thyroidectomy Hypocalcemia?
The investigators are performing this study to determine if supplementation with calcium and calcitriol (vitamin D) before surgery decreases the rate of hypocalcemia (low calcium) after surgery.
- Trial name
- NCT03869398
- Testing
- Tums, Calcitriol
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Lahey Clinic
Thyroid, Physical Activities
The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females
This Study is focused on the interaction between resting metabolic rate (RMR), physical activity (PA), and thyroid hormones (TH).
- Conditions
- Thyroid, Physical Activities, Resting Energy Expenditure
- Trial name
- NCT06377943
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Obesity, Lipid Disorders
A Clinical Study to Evaluate the Safety,Tolerability and PK of ZYT1, Following Oral Administration in Healthy Volunteers
This is a clinical study to evaluate the safety, tolerability and pharmacokinetics of ZYT1, following oral administrations in healthy volunteers. The study shall be divided into four plans as given below: 1.
- Trial name
- NCT01543269
- Testing
- ZYT1
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Rheumatoid Arthritis (RA, Osteoporosis
Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis
Generative AI (GenAI) based on large language models (LLMs) is expected to improve the diagnosis and treatment of autoimmune diseases.
- Conditions
- Rheumatoid Arthritis (RA, Osteoporosis, Osteoarthritis, Interstitial Lung Disease
- Trial name
- NCT07301892
- Testing
- Generative AI prediction report for RA complications
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Diabetes Mellitus, Hypothyroidism
Evaluation of the Effects of Teleconsultations on a Endocrinology Referral List
The aim of this study is evaluate the effects of telephone teleconsultations to primary care physicians (compared to the state's referral protocol) in the referrals waiting list for endocrinological appointments.
- Conditions
- Diabetes Mellitus, Hypothyroidism, Hyperthyroidism, Goiter
- Trial name
- NCT02710799
- Testing
- Teleconsultation, Protocol
- Where
- Brazil
- Volunteers
- 3,470 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Thyroid Nodule, Insulin Resistance
Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
It has been shown that insulin might be involved in the pathogenesis of thyroid growth. Objective To evaluate the impact of IR and metformin use on the volume of benign thyroid nodules (TNs).
- Trial name
- NCT03183752
- Testing
- Metformin
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário Clementino Fraga Filho
Primary Hypercholesterolemia
Eprotirome for the Treatment of Dyslipidemia, Efficacy and Safety 12-Week, Phase ii Study to Assess the Safety and Efficacy of KB2115 in Patients With Primary Hypercholesterolemia
Eprotirome (KB2115) is a liver selective thyroid hormone that can induce hyperthyroidism in the liver, while an euthyroid state is preserved in the extrahepatic tissue.
- Trial name
- NCT00776321
- Testing
- Eprotirome
- Where
- Sweden
- Volunteers
- 142 people
- Sponsor
- Karo Bio AB
Metabolic Syndrome
Evaluation of the Pattern of Thyroid Dysfunctions in Patients With Metabolic Syndrome
The study on evaluation the pattern of TD in MetS population may help us to know the magnitude of overlap of these two disease entities and may highlight the importance of thyroid function tests in patients with MetS.
- Trial name
- NCT03214068
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypercalcemia, Familial Primary Hyperparathyroidism
Cinacalcet to Treat Familial Primary Hyperparathyroidism
This study will evaluate the benefits and side effects of a new medication called Cinacalcet for treating patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 (MEN1) or type 2A (MEN2A).
- Trial name
- NCT00325104
- Testing
- Parathyroid hormone testing, Serum calcium testing
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)