Clinical trials: Thyroid Neoplasms
Thyroid Nodule
Evaluation of the Thyroid Volume After Radiofrequency Ablation of Thyroid Nodules and Recurrent Thyroid
Thyroid nodules are among the common alterations of the thyroid. Depending on the detection method the prevalence is between 20% and 50%, whereas the incidence increases with improvement of ultrasonic technology.
- Trial name
- NCT03395925
- Testing
- Celon Pro Surge
- Where
- Germany
- Sponsor
- Olympus Surgical Technologies Europe
Quality of Life
A Follow-up Study on Total Endoscopic Thyroidectomy Bilateral Areola Approach
Endoscopic thyroidectomy bilateral areola approach (ETBAA) is one of the most widely applied approach in China, meanwhile its safety and effectiveness has been broadly discussed since being introduced.
- Trial name
- NCT05315219
- Testing
- Endoscopic Thyroidectomy Bilateral Areola Approach
- Volunteers
- 295 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Medullary Thyroid Cancer
Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma
This is a real world study aiming to observe the efficacy and safety of Anlotinib capsules in patients with advanced medullary thyroid carcinoma, and to summarize the treatment experience in a broad population of patients.
- Trial name
- NCT05830500
- Testing
- Anlotinib Hydrochloride Capsule
- Where
- 19 sites in China
- Volunteers
- 360 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Thyroid Tumor
Impact of Dissection Area on the Clinical Outcome of Endoscopic Thyroidectomy
The purpose of this study is to investigate whether reduced subcutaneous dissection area could offer patients more clinical benefits.
- Trial name
- ET (NCT01338597)
- Testing
- endoscopic thyroidectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Military Medical University
Papillary Thyroid Carcinoma, Central Compartment Neck Dissction
The Role of Prophylactic Central Compartment Neck Dissection in the Management of 2 to 4 cm Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and is frequently associated with microscopic central neck lymph node metastases, even in the absence of preoperative clinical evidence of nodal…
- Conditions
- Papillary Thyroid Carcinoma, Central Compartment Neck Dissction, Thyroidectomy, Thyroid Lobectomy
- Trial name
- PRO-COMAND (NCT06899347)
- Testing
- Total Thyroidectomy + Central Compartment Neck Dissection, Thyroid Lobectomy + ipCCND
- Volunteers
- 392 people
- Sponsor
- Leonardo Rossi
Cancer, Solid Tumor
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
A Phase 1B/2A study will be conducted to establish safety and dose level of AMXT 1501 dicaprate in combination with IV DFMO, in cancer patients.
- Conditions
- Cancer, Solid Tumor, Solid Carcinoma, Advanced Cancer
- Trial name
- NCT05500508
- Testing
- AMXT1501, DFMO
- Where
- 7 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Aminex Therapeutics, Inc.
Thyroid Tumor
Effect of Dexmedetomidine After Thyroidectomy
The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia (reducing…
- Trial name
- NCT02412150
- Testing
- Desflurane, Remifentanil, Thyroidectomy
- Where
- South Korea
- Volunteers
- 139 people
- Sponsor
- Chosun University Hospital
Thyroid Cancer
The Evaluation of the Diagnostic Properties of Intra-operative In-situ Thyroglobin Levels of Cervical Lymph Nodes, in the Discrimination Between Benign and Malignant Lymph Nodes in Thyroid Cancer: a Prospective Multicentre Study.
Cytological examination of punctured lymph nodes is the gold standard for confirming metastatic lymph node spread of differentiated thyroid cancers.
- Trial name
- Tgcyto (NCT02602717)
- Testing
- lymph nodes cyto-punction
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Drainage, Thyroid Cancer
No Drainage During Transoral Endoscopic Thyroidectomy Vestibular Approach(TOETVA)
This study evaluates the viability and safety of no drainage tube placement during transoral endoscopic thyroidectomy vestibular approach in treatment of patients with papillary thyroid carcinoma.
- Trial name
- NCT04931576
- Testing
- no drainage tube applied
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Cancer, Thyroid Cancer
Cancer and Other Disease Risks in U.S. Nuclear Medicine Technologists
Background: The field of nuclear medicine has changed a lot in the past decades. Technology has gotten better, so patients are exposed to less radiation. But now workers are doing procedures more often and using lead aprons less.
- Conditions
- Brain Cancer, Thyroid Cancer, Circulatory Disease, Breast Cancer
- Trial name
- NCT02911155
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Nodule (Benign)
CellFX ® Percutaneous Electrode (PE) Treatment of Symptomatic Benign Thyroid Nodules
The objective of this clinical feasibility study is to evaluate initial clinical safety and device performance of the CellFX Percutaneous Electrode (PE) System for the treatment of symptomatic benign thyroid nodules.
- Trial name
- NCT06117085
- Testing
- CellFX® Percutaneous Electrode (PE) System
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Pulse Biosciences, Inc.
Head and Neck Cancer
SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck
RATIONALE: SU5416 may stop the growth of head and neck cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00005647
- Testing
- paclitaxel, semaxanib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Thyroid Cancer, Papillary Thyroid Carcinoma
Study on the Application of Convenient Foot-control Exhaust Method in Endoscopic Thyroidectomy
Endoscopic thyroidectomy developed rapidly in recent years, and the most popular surgical approach was endoscopic thyroidectomy by bilateral areola approach, but some operative steps was required optimization.
- Conditions
- Thyroid Cancer, Papillary Thyroid Carcinoma, Thyroidectomy, Endoscopy
- Trial name
- NCT03411187
- Testing
- used of the Pressure adjustable foot-control method, direct exhaust
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Bo Wang,MD
Thyroid Cancer
Cholesterol Metabolites Analysis in Human Thyroid and Iodine Resistance
The study team previously shown that a cholesterol metabolite, dendrogenin A (DDA) differentiates anaplastic thyroid cancer cell lines and that its mRNA expression is diminished in human radioiodine refractory thyroid cancer…
- Trial name
- OXYTHYR (NCT04821336)
- Testing
- Metabolites dosage
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Claudius Regaud
Thyroid Neoplasms
REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas
The primary objective of the study is to assess the anti-tumor activity of REVLIMID® (lenalidomide), administered as a single agent, in patients with distantly metastatic thyroid carcinomas which are unresponsive to systemic…
- Trial name
- NCT00287287
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kenneth Ain
Advanced Differentiated Thyroid Gland Carcinoma
COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer
Most thyroid cancers can be cured with surgery, sometimes with radioactive iodine therapy. However, some patients have cancer that has spread, and some have cancer that comes back after treatment.
- Trial name
- NCT06790589
- Testing
- Levothyroxine Oral Tablet [Synthroid]
- Volunteers
- 70 people
- Sponsor
- AHS Cancer Control Alberta
Thyroid Carcinoma, Pediatric Cancer
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer.
- Trial name
- NCT07473518
- Where
- 2 sites in Italy
- Volunteers
- 2,550 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Thyroid Cancer
Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer
The purpose of this study is to determine [for patients with previously treated well-differentiated thyroid cancer and evidence of residual disease based on serum thyroglobulin (Tg) level] whether positron emission…
- Trial name
- NCT00181168
- Testing
- Euthyroid Group
- Where
- 3 sites in United States, France
- Volunteers
- 63 people
- Sponsor
- Johns Hopkins University
Head and Neck Cancer
The Incidence and Risk Factors of Radiotherapy Induced Hypothyroidism in Head and Neck Cancer With Long Term Follow up
This is a retrospective study with long term follow up to evaluate the incidence, timing and risk factors of radiotherapy induced hypothyroidism in non-thyroid head and neck cancer patients who were treated with RT alone or in…
- Trial name
- NCT03699098
- Testing
- TSH, T3, T4 and thyroid gland DVH
- Where
- Egypt
- Volunteers
- 101 people
- Sponsor
- Cairo University