Clinical trials: Thyroid Surgeries, open to volunteers
Thyroid and Parathyroid Surgery
Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital
Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor.
- Trial name
- COTICHLO (NCT07611994)
- Testing
- Blood and thyroid tissue collection
- Where
- Guadeloupe
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Thyroid Surgery
Quantitative Intra-operative Assessment of Parathyroid Perfusion Using Indocyanine Green (ICG) Fluorescence Imaging
This single-center, prospective, three-phase observational cohort quantifies the relationship between indocyanine green (ICG) fluorescence and early parathyroid function.
- Trial name
- NCT07010341
- Testing
- ntra-operative Indocyanine Green (ICG) Fluorescence Quantification
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Fujian Medical University
Thyroidectomy, Coughing Reflex
The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Non-inflatable Transoral Endoscopic Thyroid Surgery
This study intends to implement esketamine-assisted anesthesia in patients undergoing non-inflatable transoral endoscopic thyroidectomy through a prospective randomized controlled trial, in order to observe the effect of…
- Trial name
- NCT07641673
- Testing
- Esketamine（iv）, ESK spray, Normal Saline
- Where
- China
- Volunteers
- 186 people
- Sponsor
- The Second Hospital of Anhui Medical University
Papillary Thyroid Carcinoma, Lymphatic Metastasis
Comparative Study of Transaxillary Robotic Thyroidectomy With MRND Versus Conventional Open Surgery in N1b PTC
Thyroid cancer is one of the most common malignant tumors in women, ranking seventh in the United States and fourth in China. Papillary thyroid carcinoma is the most common pathological type (about 85% to 90% of thyroid cancers)…
- Trial name
- NCT06623578
- Testing
- robotic-assisted surgery, Open Surgery
- Where
- China
- Volunteers
- 876 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Differentiated Thyroid Cancer
Nomogram for Predicting Difficult Transoral and Submental Thyroidectomy
No prior studies have stratified the difficulty of transoral and submental thyroidectomy (TOaST). The investigators aimed to investigate preoperative factors as indicators of difficult TOaSTs and to develop a predictive model…
- Trial name
- NCT06671184
- Testing
- Observations on clinicopathological factors influencing the difficulty of surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai 6th People's Hospital
Thyroid
Pilot Study for Thyroid Surgery by Preoperative Video Support and Personalized and Secure Web Platform
The medical information delivered to the patient before any surgery constitutes an essential and compulsory step during the initial management of the operated patient.
- Trial name
- AMEDOP (NCT04571736)
- Testing
- access to the internet information platform
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Montpellier
Neoadjuvant Treatment, Thyroid Cancer
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
To look at the effectiveness of zanzalintinib, followed by surgery, in treating advanced thyroid cancer. The safety of this treatment will also be studied.
- Trial name
- NCT06959511
- Testing
- Zanzalintinib
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Neoplasms
Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World Cohort Study
This multicenter registry tests whether genomically matched neoadjuvant therapy (1-4 cycles tailored to BRAF V600E, RET fusion/mutation, isolated TERT mutation, triple-negative BRAF/RET/TERT, or ICI ± TKI) can render locally…
- Trial name
- NCT07010393
- Testing
- Dabrafenib, Trametinib, Selpercatinib
- Where
- China
- Volunteers
- 335 people
- Sponsor
- Fujian Medical University
Postoperative Sore Throat
Establishment of Prediction Model for Postoperative Sore Throat
This observational study aims to identify the risk factors associated with postoperative sore throat (POST) and to develop a clinical prediction model for patients undergoing thyroid surgery under general anesthesia.
- Trial name
- NCT07088224
- Testing
- Observational studies without intervention
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Papillary Thyroid Carcinoma, Thyroid Cancer
Pattern and Surgical Outcome of Papillary Thyroid Cancer at Sohag University Hospitals
The aim of this study is to evaluate the clinicopathological pattern and surgical outcome of papillary thyroid carcinoma (PTC) at Sohag University Hospitals.
- Trial name
- NCT07823439
- Volunteers
- 30 people
- Sponsor
- Sohag University
Thyroid Cancer
Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism
The study aims to test if use of autofluorescence imaging (AF) reduces the risk of developing hypoparathyroidism (hypoPT) following surgery for thyroid cancer, either total thyroidectomy (TT) or completion hemithyroidectomy (cHT).
- Trial name
- NCT06222606
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital
Thyroid Cancer, Thyroid Nodule
Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy Assessment Score (RTAS)
To develop and validate a structured scoring tool (robotic thyroidectomy assessment score, RTAS) for assessing and quantifying surgical performance in robotic thyroidectomy (RT).
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Diseases, Thyroid Cancer, Papillary
- Trial name
- NCT06730321
- Testing
- Observations on clinicopathological factors influencing the assessment score of surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai 6th People's Hospital
Thyroid Surgery, Inadvertent Parathyroidectomy
Use of the PTEye Device to Reduce Inadvertent Parathyroidectomy During Thyroid Surgery
Inadvertent Parathyroidectomy (IP) during thyroid surgery may lead to transient or permanent hypoparathyroidism and hypocalcemia, which represents significant morbidity.
- Conditions
- Thyroid Surgery, Inadvertent Parathyroidectomy, Enlarged Thyroid
- Trial name
- NCT06927245
- Testing
- PTeye Device
- Volunteers
- 25 people
- Sponsor
- ProMedica Health System
Papillary Thyroid Cancer
Application of Mitoxantrone Hydrochloride Injection in Transoral Robotic Thyroid Cancer Surgery
Dear Patient, You are invited to participate in a clinical study investigating the Application of Mitoxantrone Hydrochloride Injection for Lymphatic Tracing in Transoral Robotic Thyroid Cancer Surgery.
- Trial name
- MHI (NCT07354698)
- Testing
- mitoxantrone hydrochloride injection
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Thyroid, Papillary Thyroid Cancer
A Study of Online Follow-up in Patients With Papillary Thyroid Cancer
The randomized, actively controlled, non-inferiority trial is scheduled to begin in August 2024 and run through August 2026. Inclusion criteria: (1) has undergone microwave ablation of thyroid or thyroidectomy (including…
- Trial name
- NCT06800482
- Testing
- online outpatient follow-up
- Where
- China
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Thyroid Nodule, Thyroid Dysfunction
Postoperative Hypocalcemia After Thyroidectomy
This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024).
- Conditions
- Thyroid Nodule, Thyroid Dysfunction, Hypocalcemia, Thyroid Cancer
- Trial name
- NCT07428057
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Minia University
Sore Throat, Tracheal Tubes With an Inner Diameter of 6.0mm
Different Models of Tracheal Catheters Are Used for Female Thyroid Glands
Objective:Compare whether the use of tracheal catheters of models 6.0 and 6.5 causes less sore throat in women after thyroid surgery compared with the traditional use of model 7.0 tracheal catheters.Methods: Investigators…
- Conditions
- Sore Throat, Tracheal Tubes With an Inner Diameter of 6.0mm, Tracheal Tubes With an Inner Diameter of 6.5mm, Tracheal Tubes With an Inner Diameter of 7.0mm
- Trial name
- NCT06967896
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Anqing Municipal Hospital
Thyroid Cancer, Surgery
Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer and has a good prognosis.According to the 2015 American thyroid association (ATA) guidelines, no gross extrathyroidal extension and the number of pathological…
- Conditions
- Thyroid Cancer, Surgery, Recurrence
- Trial name
- NCT06087068
- Testing
- Thyroxine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism
PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery"
This study aims to investigate whether an earlier measurement of parathyroid hormone can reduce the number of patients who develop symptomatic hypoparathyroidism.
- Conditions
- Postoperative Hypoparathyroidism, Postsurgical Hypoparathyroidism, Hypoparathyroidism Post-surgical
- Trial name
- PRESSPAR (NCT07491601)
- Testing
- Active vitamin D, Calcium
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Nicolas Schlegel