Clinical trials: Thyroid Surgery
Thyroid Diseases, Recurrent Laryngeal Nerve Injury
Endotracheal Tube Versus Transcartilage Needle Electrodes for Nerve Monitoring in Thyroid Surgery
Intraoperative neuromonitoring of the recurrent laryngeal nerve during thyroidectomy is most commonly performed with surface electrodes embedded in the endotracheal tube (ETT).
- Conditions
- Thyroid Diseases, Recurrent Laryngeal Nerve Injury, Vocal Cord Paralysis, Thyroid Nodule
- Trial name
- TRANSCOMP (NCT07902349)
- Testing
- Transcartilage needle electrode recording, Endotracheal tube surface electrode recording
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
THYROIDECTOMY
The Optimal Dosage of Rocuronium for Intraoperative Neuromonitoring During Thyroid Surgery
The investigators tried to explore an alternative non-depolarizing muscle relaxant (rocuronium) and its optimal dosage to replace succinylcholine for IONM during thyroid surgery.Time frame of outcome measure was during 30 to…
- Trial name
- IONM (NCT02377882)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Thyroid Cancer, Thyroid and Parathyroid Surgery
The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response
The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of…
- Conditions
- Thyroid Cancer, Thyroid and Parathyroid Surgery, Hyperthyreosis and Goiter, Surgical Stress Response
- Trial name
- NCT07600580
- Testing
- bilateral ultrasound guided intermediate cervical plexus block with 0,25% levobupivacaine
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- University Hospital Dubrava
Pediatric and Adolescent Differentiated Thyroid Carcinoma, SEER Database Analysis
Clinical and Surgical Outcomes of Thyroid Carcinoma in Children and Adolescents
This study aims to investigate the differences in clinical characteristics, causes of death, long-term survival, and surgical approaches between pediatric and adolescent follicular and papillary carcinoma by exploring data from…
- Trial name
- CPSO-TC (NCT06592118)
- Testing
- Different Pathological Types (FTC vs PTC)
- Volunteers
- 3,068 people
- Sponsor
- Dezhou Hospital Qilu Hospital of Shandong University
Thyroid Cancer
Comparison of Quality of Life in Patients with Differentiated Thyroid Carcinoma Undergoing Different Surgery
The incidence of thyroid cancer has increased rapidly in recent years, especially in women. Early differentiated thyroid cancer has a good prognosis, and surgery is the main treatment.
- Trial name
- NCT06037174
- Testing
- minimally invasive procedure, Conventional Open Surgery
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Proliferative Thyroid Disease
DIM as a Treatment for Thyroid Disease
Diindolylmethane (DIM), a dietary supplement, found naturally in cruciferous vegetables (such as cabbage, cauliflower, broccoli, \& Brussels sprouts) has been studied extensively in recent years for its anti-cancer effects.
- Trial name
- NCT01846364
- Testing
- Diindolylmethane (DIM)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The New York Eye & Ear Infirmary
Multinodular Goitre, Grave's Disease
A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery
This is a randomized, prospective equivalence trial on the safety of the Ligasure Vessel Sealing System as used in thyroid surgery.
- Conditions
- Multinodular Goitre, Grave's Disease, Thyroid Nodule
- Trial name
- NCT01163565
- Testing
- Ligasure Device
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Alberta
Thyroid and Parathyroid Surgery
Analysis of Chlordecone Tissue Concentrations in Patients Treated for Thyroid Surgery at Guadeloupe University Hospital
Chlordecone, an organochlorine pesticide used in the French Caribbean for several decades, is recognized as an endocrine disruptor.
- Trial name
- COTICHLO (NCT07611994)
- Testing
- Blood and thyroid tissue collection
- Where
- Guadeloupe
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Thymectomy, Thyroid Cancer
Comparing the Therapeutic Efficacy of Extended Isthmusectomy Versus Total Thyroidectomy for Isthmus Tumors of the Thyroid
Prospective randomized open phase III non-inferiority trial in cT1bN0N1aM0 isthmus tumors of the thyroid comparing: extended Isthmusectomy (Isthmusectomy + Central Neck Dissection)(experimental group) versus total thyroidectomy +…
- Trial name
- NCT07274605
- Testing
- Total thyroidectomy, Extended isthmusectomy
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thyroid Diseases, Surgery
The Safety and Feasibility of Transoral Endoscopic Thyroidectomy Vestibular Approach
This is a single center, prospective case series designed to assess the safety and feasibility of TOETVA in a small cohort of patients at University Health Network Toronto.
- Trial name
- NCT04842942
- Testing
- TOETVA
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Thyroid Cancer
Non-inferiority Investigation to Evaluate the Efficacy and Safety of the Ultrasonic Surgical System
The objective of this clinical investigation is to evaluate the efficacy and safety of the Ultrasonic Surgical System in the clinical application produced by Ezisurg Medical Co., Ltd.
- Trial name
- NCT07235553
- Testing
- Ultrasonic Surgical System, HARMONIC System
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Ezisurg Medical Co. Ltd.
Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma
Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery
This phase II trial studies how well sunitinib malate works in treating patients with thyroid cancer that did not respond to iodine I 131 (radioactive iodine) and cannot be removed by surgery.
- Conditions
- Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma, Stage III Thyroid Gland Follicular Carcinoma AJCC v7
- Trial name
- NCT00381641
- Testing
- Laboratory Biomarker Analysis, Pharmacogenomic Study, Sunitinib
- Where
- 17 sites in United States
- Volunteers
- 63 people
- Sponsor
- National Cancer Institute (NCI)
Non-morbidly Obese Patients (BMI<35), Equiring General Anesthesia With Intubation With a Nerve Integrity Monitor (NIM) Tube
Decurarisation Kinetics of Rocuronium in Cervical Surgery
Recurrent nerve monitoring for thyroid and parathyroid surgery contraindicates the pharmacologically active presence of muscle relaxant agents at the time of dissection.
- Conditions
- Non-morbidly Obese Patients (BMI<35), Equiring General Anesthesia With Intubation With a Nerve Integrity Monitor (NIM) Tube, Thyroid and Parathyroid Surgery
- Trial name
- CIDEROC (NCT05126108)
- Testing
- Thyroid and parathyroid surgery, Recurrent nerves monitoring
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Thyroid Gland Undifferentiated (Anaplastic) Carcinoma
Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer
This phase II trial studies how well pembrolizumab, chemotherapy, and radiation therapy work with or without surgery in treating patients with anaplastic thyroid cancer.
- Trial name
- NCT03211117
- Testing
- Docetaxel, Doxorubicin Hydrochloride, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Goiter, Nodular
Galectin 3 Dosage in Diagnosis of Nodular and Multinodular Goiter
The investigators will dose galectin 3 in plasma and water rinse of the needle aspiration biopsy in patients with thyroid nodules.
- Trial name
- Galectins (NCT01588288)
- Testing
- Galectin 3 dosage
- Where
- 2 sites in France
- Volunteers
- 193 people
- Sponsor
- University Hospital, Rouen
Postoperative Nausea and Vomiting
Impact of Drains on Postoperative Nausea and Vomiting After Thyroid Surgery
Wound Drains after Thyroid- and Parathyroid Surgery Impact on Postoperative Nausea and Vomiting (PONV)
- Trial name
- PONTS (NCT01679418)
- Testing
- Placement of a wound drain post surgery (Redon; Medicoplast), No-drain after surgery
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Kantonsspital Liestal
Nausea, Vomiting
Evaluation of 2 Doses of Intravenous Droperidol in the Prevention of Postoperative Nausea
In this prospective, randomised, placebo-controlled study, the researchers determined whether 0.625 mg or 2.5 mg of IV droperidol given 30 min before emergence from general anaesthesia reduces the incidence of immediate and…
- Trial name
- DIPAVO (NCT00445055)
- Testing
- Droperidol
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Bordeaux
Thyroid Neoplasm, Thyroid Carcinoma
Clinical Evaluation of 18F-DOPA Positron Emission Tomography in Medullary Thyroid Cancer
Medullary thyroid carcinoma (MTC) is a rare tumor arising from C cells of the thyroid gland and belonging to the endocrine tumors.
- Conditions
- Thyroid Neoplasm, Thyroid Carcinoma, Medullary Carcinoma
- Trial name
- DOPMET (NCT00647140)
- Testing
- 18F-L-DOPA PET
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris