Clinical trials: Thyroid Surgery
Malignant Thyroid Gland Neoplasm, Poorly Differentiated Thyroid Gland Carcinoma
Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer
This phase II trial studies the effect of selpercatinib given before surgery in treating patients with thyroid cancer whose tumors have RET alterations (changes in the genetic material [deoxyribonucleic acid (DNA)]).
- Conditions
- Malignant Thyroid Gland Neoplasm, Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Thyroid Gland Anaplastic Carcinoma
- Trial name
- NCT04759911
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Selpercatinib
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Hypoparathyroidism Post-surgical, Quality of Life
Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life
Postoperative hypoparathyroidism (hypoPT) is the most frequent complication after total thyroidectomy (TT). It is caused by impaired parathyroid function, leading to low calcium levels, patient discomfort, reduced quality of life…
- Trial name
- NCT07381998
- Testing
- high-dose calcium (400 mg x 4), vitamin D (19 mikg x 4), and active vitamin D supplementation (2 mikg x 2), Ommit routine blood test post operative day 1
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Papillary Thyroid Carcinoma, Thyroid Cancer
Cross-sectional Case and Control Study on Quality of Life, Appearance and Functions in PTC Via Different Surgical Approach
An observational cross-sectional case-control study on the postoperative quality of life (5 aspects, general quality of life, thyroid specific quality of life, scar appearance, voice and swallowing functions) of papillary thyroid…
- Trial name
- NCT05932121
- Testing
- Thyroid lobectomy via trans-axillary approach, Thyroid lobectomy via open approach
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Thyroid Surgery
The Effect of the Application of Head Mounted Magnifying Glasses on Postoperative PTH Changes in Thyroid Surgery: Stage II
This study is a prospective research. This study aims to investigate and follow up patients who undergo open thyroidectomy in the Department of Breast and Thyroid Surgery at Shandong Provincial Hospital from January 2020 to…
- Trial name
- NCT06838728
- Testing
- Head Mounted Magnifying Glasses
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong Provincial Hospital
Thyroid Nodule (Diagnosis)
Safety & Feasibility of Ultrasound-assisted Non-invasive Measurement of Compressibility of the Thyroid Gland in Patients Scheduled for Surgical Removal
The thyroid gland plays an important role in hormone regulation however, it is often prone to nodules. This is common with nodules being found in up to 68% of people in a neck ultrasound, with likelihood increasing with age.
- Trial name
- NCT07102264
- Testing
- CPMX1
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Papillary Thyroid Cancer
A Clinical Study on the Benefits of Carbon Nanoparticles Injection Time in Patients With Thyroid Cancer.
The detection rate of thyroid cancer (PTC) has increased rapidly in recent years. Except undifferentiated cancer, surgery is still one of the most important treatments for all types of thyroid cancer, and there is a consensus to…
- Trial name
- NCT06791005
- Testing
- Preoperative Injection of Carbon Nanoparticles, Intraoperative Injection of Carbon Nanoparticles
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Thyroid Cancer
The Effect of the Application of Head Mounted Magnifying Glasses on Postoperative PTH Changes in Thyroid Surgery
This study collected data on open thyroidectomy patients admitted to the Breast and Thyroid Surgery Department of Shandong Provincial Hospital from January 2020 to December 2023 by reviewing medical records.
- Trial name
- NCT06432257
- Testing
- head mounted magnifying glass assistance
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong Provincial Hospital
Blood Pressure, Diseases of the Thyroid Gland
The Relationship Between Upper and Lower Extremity Blood Pressure in Thyroid Surgery Patients Under General Anesthesia
The goal of this observational study is to clarify the relationship between upper and lower limb blood pressure in thyroid surgery patients under general anesthesia.
- Trial name
- NCT06590064
- Testing
- Non-invasive Blood Pressure Measurement
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- Ilsan Cha hospital
Thyroid Surgeries, Intraoperative Analgesic Use
qCON/qNOX-Guided Anesthesia in Patients Undergoing Thyroidectomy Surgery
The aim of this study is to evaluate the effect of using the non-invasive Conox monitor on intraoperative opioid consumption. Additionally, the study aims to assess the impact of Conox monitoring on recovery time, postoperative…
- Conditions
- Thyroid Surgeries, Intraoperative Analgesic Use, Anesthesia Depth Monitoring
- Trial name
- NCT07445659
- Testing
- Connox EEG Monitoring, standard anesthesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Thyroid Surgery
Intra Operative Continuous Laryngeal Nerve Monitoring During Thyroid Surgery and Interpretation of the Post-operative Voice Quality in Relation to the Electromyography Data Obtained During Surgery
During thyroid surgery the laryngeal recurrent nerves (and for this reason the voice quality) are at risk. Therefore intra operative continuous neuromonitoring could help to prevent harm to these nerves.
- Trial name
- CoNeMoTS (NCT01413802)
- Testing
- Continuous nerve monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Thyroid Carcinoma, Robot Surgery
Comparative Study of Robot BABA Approach and Chest Breast Approach for Lateral Neck Dissection
Objective to compare the advantages and disadvantages of robotic and conventional endoscopic thyroidectomy for thyroid cancer.
- Conditions
- Thyroid Carcinoma, Robot Surgery, Endoscopic Surgery
- Trial name
- NCT03500666
- Testing
- Robot, Total endoscopic
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Fujian Medical University
Post-operative Pain
Open Thyroid Surgery With Pillow Versus no Pillow for Better Post-operative Outcomes
Primary: To compare the post-operative pain in patients with neck extension and without neck extension. Secondary: To determine the benefit of neck exposure and peri-operative complications, which include duration of operation…
- Trial name
- NCT01620151
- Testing
- Extended neck with standard support or pillow
- Where
- 2 sites in Hong Kong
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Thyroid Cancer, Thyroid Nodule
Voice Outcomes Following Thyroidectomy
This is an observational study of voice outcomes in participants following thyroidectomy or another head and neck surgery that does not involve risk to the larynx other than risks incurred due to intubation alone.
- Trial name
- NCT03657654
- Testing
- No intervention: observational only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Virginia
Thyroid Cancer
Safety and Efficacy Study of Ultrasonic Coagulation Device and Bipolar Energy Sealing System
The aim of the study is to evaluate differences between use of Ultrasonic Coagulation Device (New Harmonic ACE™, Ethicon endo-surgery) and Bipolar Energy Sealing System (LigaSure Precise™, Covidien) in surgery for thyroid cancer.
- Trial name
- UCBEST (NCT01565486)
- Testing
- Ultrasonic coagulation device (Harmonic ACE® scalpel), bipolar energy sealing system (LigaSure Precise)
- Where
- South Korea
- Volunteers
- 304 people
- Sponsor
- Seoul St. Mary's Hospital
Thyroid Cancer, Surgery
Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer and has a good prognosis.According to the 2015 American thyroid association (ATA) guidelines, no gross extrathyroidal extension and the number of pathological…
- Conditions
- Thyroid Cancer, Surgery, Recurrence
- Trial name
- NCT06087068
- Testing
- Thyroxine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Surgical Wound Infection, Thyroid Nodule
Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy
Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.
- Trial name
- POTO (NCT03295955)
- Testing
- Amoxicillin Clavulanate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Thyroid Eye Disease, TED
Triamcinolone Acetonide Injection for Upper Eyelid Retraction in Thyroid Eye Disease
Thyroid eye disease frequently causes upper eyelid retraction, which can lead to ocular surface complications and cosmetic concerns.
- Trial name
- TREAT-OT (NCT07471997)
- Testing
- Triamcinolone Acetonide
- Where
- Mexico
- Volunteers
- 29 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Thyroidectomy
Use of an Oxidized Regenerated Cellulose After Thyroid Surgery: A Prospective, Randomized Study
The purpose of this study is to evaluate the effects and safety of oxidized, regenerated cellulose as an absorbable adhesion barrier after thyroidectomy.
- Trial name
- ORC (NCT01171079)
- Testing
- application of oxidized regenerated cellulose
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Objective Vocal Cord Movement Assessment by C-Mac Videolaryngoscope Vs Airway Ultrasound in Ca Thyroid
Comparison of Two Technique for Assessment of Vocal Cord Movement by C-Mac Videolaryngoscope vs Airway Ultrasound.
This study is planned to compare C-Mac video-laryngoscope and airway ultrasound as two novel techniques (causing least discomfort to the patients) for the detection of impaired vocal-cord movement after thyroid surgery.
- Trial name
- NCT02847780
- Testing
- Active Comparator :C-Mac Videolaryngoscope, Experimental: Airway ultrasound,
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Parathyroid, Intraoperative Monitoring
Protective Effect of Intraoperative Parathyroid Gland Auxiliary Recognition System in Thyroid Malignant Tumor Operation
This intraoperative parathyroid gland auxiliary recognition system uses the principle of parathyroid gland autofluorescence to assist surgeons in accurately identifying and protecting parathyroid glands during surgery, reducing…
- Conditions
- Parathyroid, Intraoperative Monitoring, Thyroid Cancer
- Trial name
- NCT04560426
- Testing
- Intraoperative parathyroid gland auxiliary recognition system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University