Clinical trials: Tick-Borne Infections
Tick-borne Encephalitis (TBE)
TBE Seropersistence up to 10 Years After First Booster in Adults
The purpose of this study is to evaluate TBE antibody persistence from 7 to 10 years after the first booster TBE vaccination with FSME-IMMUN 0.5ml.
- Trial name
- NCT01582698
- Testing
- FSME-IMMUN 0.5 ml
- Where
- 2 sites in Poland
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease, Tick-Borne Diseases
Lyme Disease Prevention Program
This is a large study of an educational program on Lyme disease prevention for passengers on ferry boats going to Nantucket Island during the period from Memorial Day until Labor Day.
- Trial name
- NCT00000432
- Testing
- Education about disease prevention
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Lyme Disease, Healthy
Lyme Disease Diagnostic Assay - Collection of Whole Blood
The primary objective is to obtain whole blood from subjects with signs and/or symptoms of early Borrelisois. Whole blood will also be obtained from subjects with suspicion of acute Borreliosis and under medical examination for…
- Trial name
- NCT05041595
- Testing
- Lyme diagnostic assay
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- DiaSorin Inc.
Encephalitis, Tick-Borne
TBE Antibody Persistence and Booster Vaccination Study in Adults (Follow-up to Study 223)
The purpose of this study is to assess: TBE antibody persistence 24, 34, 46 and 58 months (as applicable) after the first booster TBE vaccination with FSME-IMMUN 0.5ml given in Study 223, by means of ELISA (IMMUNOZYM FSME IgG)…
- Trial name
- NCT00503529
- Testing
- Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
- Where
- 2 sites in Poland
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease, Post Treatment Lyme Disease
Navigating Pregnancy and Parenthood With Lyme Disease
This is a mixed methods study exploring the experiences of pregnancy and parenting among participants with Lyme disease. Eligible participants will have been diagnosed with Lyme disease (LD), post-treatment Lyme disease syndrome…
- Conditions
- Lyme Disease, Post Treatment Lyme Disease, Chronic Lyme Disease, Tick-Borne Infections
- Trial name
- NCT06397794
- Testing
- Quantitative surveys and qualitative interview
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Lyme Neuroborreliosis
An Intervention in a Primary Healthcare Setting to Reduce Lyme Neuroborreliosis Treatment Delay
This study evaluates the effect of written and oral information in a primary health care setting on 1) patients referred to specialised examination for Lyme neuroborreliosis, 2) delay from patient symptom debut to treatment for…
- Trial name
- NBdelay (NCT03820999)
- Testing
- Oral and written information on tick-bites and Lyme disease
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Tularemia
Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine
This study is designed to determine the safety and immunogenicity of a Live Francisella tularensis Vaccine
- Trial name
- NCT00584844
- Testing
- Live F tularensis Vaccine
- Where
- United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Lyme Arthritis
Borrelia Arthritis - a Hidden Cause of Arthritis in Danish Patients?
Why is this study being done? Borrelia arthritis is a joint infection caused by Borrelia bacteria transmitted by tick bites. It often affects the knee and can cause prolonged pain and swelling if not diagnosed and treated in…
- Trial name
- NCT07351721
- Testing
- Synovial fluid Borrelia burgdorferi PCR
- Volunteers
- 350 people
- Sponsor
- Fredrikke Christie Knudtzen
Lyme Disease
A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick Exposure
This study is designed to evaluate the safety, tolerability, and pharmacokinetics of TP05 administered orally to healthy adult participants.
- Trial name
- NCT07562087
- Testing
- TP-05 (lotilaner) Low Dose, TP-05 (lotilaner) High Dose
- Where
- 19 sites in United States
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Tarsus Pharmaceuticals, Inc.
Tick Borne Encephalitis, Virus Diseases
Study to Evaluate Long Term Immunogenicity up to 10 Years After the First Booster Immunization With Tick Borne Encephalitis Vaccine in Adults Who Received 1 of 3 Different Primary Vaccination Schedules
The aim of this study is to investigate the immunogenicity response in adults up to 10 years after one booster dose. Data collected from this study will allow for greater information to prescribers who administer TBE vaccine, so…
- Trial name
- NCT01562444
- Testing
- Blood draw
- Where
- Czechia
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lyme Disease, Erythema Migrans
Erythema Migrans in Elderly
The investigators will focus on elderly patients with early Lyme borreliosis with the aim of assessing clinical course, serological response and treatment outcome of the disease as compared to younger adults.
- Conditions
- Lyme Disease, Erythema Migrans, Elderly Infection
- Trial name
- NCT03371563
- Testing
- Antibiotics, no intervention
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Lyme Disease
Clinical Manifestations and Long-Term Outcome in Early Lyme Neuroborreliosis
In this retrospective cohort study of patients with early Lyme neuroborreliosis (LNB), clinical and microbiologic characteristics and long-term outcome of definite vs.
- Trial name
- NCT04653558
- Where
- Slovenia
- Volunteers
- 311 people
- Sponsor
- University Medical Centre Ljubljana
Relapsing Fever, Tick-borne, Jarisch Herxheimer Reaction
Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever
Abstract Background Tick-Borne Relapsing Fever (TBRF) is an acute febrile illness. In Israel, TBRF is caused by Borrelia persica and is transmitted by Ornithodoros tholozani ticks.
- Trial name
- NCT00237016
- Testing
- doxycycline treatment
- Where
- Israel
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Tick Borne Encephalitis
Application of a TBE-Vaccine in Obese Persons
Obese people have an altered immune responsiveness. The present study investigates whether this influences immune responses to booster vaccinations (i. e.
- Trial name
- NCT04017052
- Testing
- FSME-IMMUN Vaccine
- Where
- Austria
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Lyme Disease, Lyme Disease, Chronic
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Lyme Disease
- Trial name
- NCT04148222
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Tick Bites, Tick-borne Diseases
Tick-borne Illness and Clothing Study of Rhode Island
Lyme and other tick-borne diseases pose a significant health threat to outdoor workers. This study is a double-blind randomized controlled trial of outdoor workers in Rhode Island and the surrounding area that will address the…
- Trial name
- NCT02613585
- Testing
- Permethrin Impregnated Clothing
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tick-Borne Encephalitis
Study to Evaluate the Immunogenicity, Safety, and Tolerability of a Tick-Borne Encephalitis (TBE) Vaccine in Healthy Japanese Participants 1 Year of Age and Older
The main purpose of this study is to provide safety and immunogenicity data in Japanese participants.
- Trial name
- NCT04648241
- Testing
- TBE vaccine 0.5 mL, TBE vaccine 0.25 mL
- Where
- 6 sites in Japan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease
ImmuneSense Lyme Study
ImmuneSense Lyme is a study, which is designed to better understand the immune response to Lyme disease. This is critically important because the immune system may be able to tell us important information about how our own bodies…
- Trial name
- NCT04422314
- Testing
- T-Detect Lyme
- Where
- 34 sites in United States
- Volunteers
- 893 people
- Sponsor
- Adaptive Biotechnologies
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge