Clinical trials: Tinnitus
Hearing Loss, Tinnitus
Progressive Intervention Program for Tinnitus Management
The purpose of this multi-site randomized clinical study is to test a model treatment program in a VA Audiology clinic, to evaluate its efficacy, ease of implementation, and acceptability to audiologists.
- Trial name
- NCT00371436
- Testing
- Progressive Audiologic Tinnitus Management, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 181 people
- Sponsor
- US Department of Veterans Affairs
Tinnitus
Use of Modafinil in the Treatment of Tinnitus
A study on the effects of the FDA approved drug Modafinil upon attention problems associated with tinnitus. This is considered to be a safe drug with few side effects.
- Trial name
- NCT00591019
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Tinnitus
Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus
One out of every five people experience tinnitus (a buzzing, ringing, or roaring sound in the ear) ranging from mild to severe impairment. To date there is no effective therapy that seems to help the tinnitus sufferer.
- Trial name
- NCT00329524
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Hearing Loss, Sensorineural, Tinnitus
Evaluation of the Clinical Benefit of the Hearing Aids Tinnitus Feature.
Participants with hearing loss and Tinnitus will wear hearing aids with amplification-only or with an added sound, and have their tinnitus level evaluated before and after intervention.
- Trial name
- NCT05292534
- Testing
- hearing aid amplification, hearing aid amplification with an added sound
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Sonova AG
Tinnitus
Cochlear Promontory Stimulation for Treatment of Tinnitus
Tinnitus is the perception of sound when no external noise is present. The Center for Disease Control (CDC) estimates over 50 million - nearly 15% of the general public -experience some form of tinnitus.
- Trial name
- NCT03759834
- Testing
- Cochlear promontory stimulation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tinnitus
Somatosensory Tinnitus Study
Somatosensory tinnitus is suspected when the tinnitus perception changes following head, neck, or jaw maneuvers. The prevalence of this type of tinnitus in Veterans in unknown.
- Trial name
- NCT03802513
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Meniere Disease, Ménière
SPI-1005 for the Treatment of Meniere's Disease
The study is a randomized, double-blind, placebo-controlled, multi-center clinical trial (RCT) with open-label extension study (OLE), of SPI-1005 in adult subjects with definite Meniere's disease with active symptoms within three…
- Trial name
- STOPMD-3 (NCT04677972)
- Testing
- Ebselen
- Where
- 12 sites in United States
- Volunteers
- 220 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Noise-Induced Hearing Loss
Micronutrients to Prevent Noise-induced Hearing Loss
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. Studies in animals have allowed us to identify mechanisms contributing to NIHL, including direct mechanical trauma, free radicals formed in…
- Trial name
- NCT00808470
- Testing
- beta-carotene, vitamins C and E, magnesium
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Tinnitus
Inhibitor Masking Device & Sodium Channel, Voltage Gated, Type IX Alpha Subunit (SCN9) Gene Expression
To evaluate the effectiveness of the Inhibitor™ Tinnitus Masking Device. To determine if there is a higher incident of expression of the sodium channel, voltage gated, type IX alpha subunit (SCN9) gene in those subjects with…
- Trial name
- NCT01412918
- Testing
- The Inhibitor™ Tinnitus Masking Device
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Tinnitus
Internet-based Versus Face-to-face Clinical Care for Tinnitus
The purpose of this study is to compare the effectiveness of a CBT-based internet intervention with face to face standard clinical care for adults with tinnitus in the United Kingdom.
- Trial name
- NCT02665975
- Testing
- CBT-based internet-intervention for tinnitus, Face-to-face clinical tinnitus care
- Where
- 3 sites in United Kingdom
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Tinnitus
An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus
The primary objective of this study is to evaluate the safety and tolerability of brexanolone in participants with tinnitus following a single 6-hour continuous intravenous (IV) infusion.
- Trial name
- NCT05645432
- Testing
- Brexanolone
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Tinnitus
Mahana Tinnitus Pilot
The main objective of this prospective, open-label, non-significant risk study is to assess the efficacy and safety of Mahana™ Tinnitus together with care as usual in approximately 250 adults with symptoms of tinnitus.
- Trial name
- NCT05696158
- Testing
- MHNA-003
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Mahana Therapeutics
Tinnitus
Zinc to Treat Tinnitus in the Elderly
There is widespread belief and some evidence to indicate that zinc can successfully treat tinnitus. Zinc deficiency is more likely to occur in the elderly .
- Trial name
- NCT00683644
- Testing
- Zinc
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Iowa
Stress Disorders, Post-Traumatic, Tinnitus
Network Dysregulation Among Individuals With Comorbid Tinnitus and PTSD
Evaluation of the overlap between tinnitus-related distress and symptoms of Post Traumatic Stress Disorder (PTSD), to identify functional covariance among resting-state networks among individuals with tinnitus and PTSD
- Trial name
- NCT03702166
- Testing
- Cognitive Processing Therapy (CPT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tinnitus
Telephone Tinnitus Education for Patients With Traumatic Brain Injury (TBI)
This study continues the investigators' efforts to develop tinnitus management protocols for Veterans. More specifically, this study developed and evaluated an adaptation of Progressive Tinnitus Management (PTM) for use as a…
- Trial name
- NCT01129141
- Testing
- Tele-PTM, Wait List Control
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- VA Office of Research and Development
Tinnitus
A Comparison of Three Psychoeducational Group Interventions for Veterans With Tinnitus
Tinnitus (i.e., ringing in the ears) is currently the most prevalent disability among Veterans. A range of clinical interventions has been created to systematically address the range of issues caused by tinnitus.
- Trial name
- NCT02293512
- Testing
- Coping Effectiveness Training, Cognitive-behavioral therapy, Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media
Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose
The study objective is to compare the CBCT images generated by the CS 9300 to those generated by conventional CT.
- Conditions
- CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media, Otospongiosis, Otosclerosis
- Trial name
- CBCT-ENT (NCT01855425)
- Testing
- Radiation
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 96 people
- Sponsor
- Carestream Health, Inc.
Tinnitus
Internet-based Cognitive Behavioural Therapy for Spanish Tinnitus Sufferers
Nearly 50 million people in the U.S. experience tinnitus, of which about 20 million people have burdensome chronic tinnitus. Tinnitus can be very debilitating as many aspects of daily life can be affected, such as sleep, mood…
- Trial name
- ICBT (NCT04335929)
- Testing
- Internet-based Cognitive Behavior Therapy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lamar University
Tinnitus
Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus
Tinnitus, or ringing in the ears, is a very common problem that often accompanies hearing loss. It affects up to 1 in 10 adults, and about 30% of people who experience chronic tinnitus find it very distressing.
- Trial name
- NCT03336398
- Testing
- Ketamine Hydrochloride in saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- New York State Psychiatric Institute
Tinnitus
Efficacy of the Erchonia Corporation THL™ for Providing Relief of Tinnitus Symptoms
The purpose of this clinical study is to determine the effectiveness of the Erchonia® THL™, manufactured by Erchonia Corporation (the Company), for prescription home use in providing relief of tinnitus symptoms when used by…
- Trial name
- NCT05374421
- Testing
- Erchonia® THL™
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Erchonia Corporation