Clinical trials: Tissue Adhesion, open to volunteers
Vestibular Schwannoma
3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular…
- Trial name
- NCT07844460
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shengjing Hospital
Leukocyte Adhesion Deficiency
A Study to Evaluate Efficacy and Safety of AVTX-803 in Patients With Leukocyte Adhesion Deficiency Type II
The primary objective of this study is to evaluate the efficacy and safety of AVTX-803 compared to withdrawal in patients with Leukocyte Adhesion Deficiency, Type II (LAD II).
- Trial name
- NCT05462587
- Testing
- AVTX-803 (L-Fucose)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- AUG Therapeutics
Premature Ovarian Insufficiency, Intrauterine Adhesion
Application of Platelet-rich Plasma (PRP) in Reproductive Medicine
Female fertility is affected by many factors, such as ovarian function, fallopian tube patency, uterine environment, and mental state, among which the ovaries and endometrium are more important.
- Conditions
- Premature Ovarian Insufficiency, Intrauterine Adhesion, Poor Ovarian Response, Repeated Implantation Failure
- Trial name
- NCT06645379
- Testing
- Platelet-Rich Plasma (PRP) Injections
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Advanced Adenocarcinoma
Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.
The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma
- Trial name
- NCT05808634
- Testing
- BA3182
- Where
- 9 sites in United States
- Volunteers
- 168 people
- Sponsor
- BioAtla, Inc.
Adhesions, Hand Fractures
Lipofilling in Operative Hand Fracture Treatment
Background: Hand fractures are a common clinical problem worldwide and account for a substantial economic burden and workload for experienced hand surgeons.
- Conditions
- Adhesions, Hand Fractures, Tenolysis
- Trial name
- NCT07815444
- Testing
- Lipofilling in Operative Treatment of Proximal Phalanx Fractures and Related Tenolysis
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Jeroen Bosch Ziekenhuis
Myoma
Prevention of Intra-uterine Adhesions Following Laparoscopic and Laparotomic Myomectomy
Clinical study on the prevention of intrauterine adhesions after laparoscopic or laparotomic myomectomy. Myomas are common in women of reproductive age and myomectomy can lead to intra-uterine adhesions, which can be detrimental…
- Trial name
- PALLM (NCT05683041)
- Testing
- Hyalobarrier
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Poor Aesthetic of Existing Restoration of Tooth, Dental Restoration Failure of Marginal Integrity
The Effect of Different Adhesion Strategies on the Clinical Success
The study will involve 41 people who regularly seek treatment at clinics. Participants must be in generally good health and be older than eighteen.
- Conditions
- Poor Aesthetic of Existing Restoration of Tooth, Dental Restoration Failure of Marginal Integrity, Unacceptable Morphology of Tooth Restoration, Secondary Caries
- Trial name
- NCT06500546
- Testing
- Treatment of cervical lesions
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Endometriosis, Abdominal Adhesions
The Effect of Temporary Ovarian Suspension to the Abdominal Wall During Laparoscopic Endometriosis Surgery for Adhesion Prevention -A Comparative and Prospective Study
Pelvic adhesions, particularly between ovaries and pelvic sidewall, frequently complicate endometriosis surgery. Despite various interventions, no widely accepted solution exists.
- Trial name
- NCT07087756
- Testing
- laparoscopic ovarian suspension
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Carmel Medical Center
Adhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions
Adhesion Prevention in ASBO Surgery Using 4DryField® PH
Post-surgical adhesions occur in up to 90% of abdominal surgeries, often leading to complications like adhesive small bowel obstruction (ASBO) and chronic pain.
- Conditions
- Adhesive Small Bowel Obstruction, Postoperative Abdominal Adhesions, Bowel Obstruction, Abdominal Surgery Complications
- Trial name
- ADHERE (NCT07078981)
- Volunteers
- 189 people
- Sponsor
- Alessio Giordano
Cornea Disease
A Single-Center Clinical Study to Evaluate the Efficacy and Safety of a Suture-Free Ophthalmic Hydrogel for Ocular Surface Tissue Adhesion
When severe ocular surface lesions occur (e.g., pterygium, corneal ulcer, ocular surface burn, etc.), the currently clinically common surgical procedures such as conjunctival flap coverage, amniotic membrane transplantation, and…
- Trial name
- NCT07608367
- Testing
- Suture-Free Ophthalmic Hydrogel for Ocular Surface Surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Suxia Li
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Adhesive Small Bowel Obstruction
Elective Adhesiolysis vs. a Wait-and-see Policy to Prevent Recurrences After Conservative Treatment of Adhesive Small Bowel Obstruction
Rationale: Adhesive small bowel obstruction (aSBO) is a frequent surgical emergency, associated with 3-8% hospital mortality and a high risk of recurrence (20% at two years of follow-up).
- Trial name
- AWARE (NCT06777446)
- Testing
- Elective Adhesionlysis, Adhesion barrier
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 380 people
- Sponsor
- Radboud University Medical Center
Retention
Restoration of Non-carious Cervical Lesions With Different Resin Composites and Universal Adhesive
patients with non carious cervical lesions suffer from dentin sensitivity and presence of cavitations and gingival recession. Restoring these lesions with different composites and evaluation of restorations every 6 months will be…
- Trial name
- NCT06393699
- Testing
- composite restoration
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cerebral Palsy
Comparison of Two Ankle Foot Orthosis on Mobility, Participation and Adhesion in Childrend With Cerebral Palsy
Children with cerebral palsy (CP) present a variety of motor impairments and activity limitations. Plastic ankle-foot orthoses (pl-AFO) are frequently prescribed to improve their gait.
- Trial name
- DynamicPC (NCT07301593)
- Testing
- orthosis use
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Idiopathic Parkinson Disease
Adhesion and Safety of Rotigexole Compared to Neupro®
A non-inferiority open-labelled crossover randomized controlled trial, of two arms, to investigate the adhesiveness and safety of Rotigexole 8 mg/24 hours transdermal patch, manufactured by Eva pharma, Egypt, compared to the…
- Trial name
- START (NCT07015346)
- Testing
- Rotigexole 8 mg, Neupro ® 8 mg
- Volunteers
- 40 people
- Sponsor
- Eva Pharma
Healthy Women, Menstruation
The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise
The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40.
- Conditions
- Healthy Women, Menstruation, Resistance Exercise
- Trial name
- NCT06985420
- Testing
- Resistance exercise, Menstrual Cycle Phases
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Central Florida
Adhesions Abdominal
Prediction of Adhesion by Sliding Sign
Sliding sign will be checked by ultrasonography by transabdominal and transvaginal route before operation of patients that had cesarean section three or more. During cesarean section adhesions will be evaluated and noted.
- Trial name
- Prediction (NCT06841146)
- Testing
- routine cesarean section
- Volunteers
- 100 people
- Sponsor
- Sanliurfa Education and Research Hospital
Adhesive Small Bowel Obstruction
Optimizing Treatment of Adhesive Small Bowel Obstruction
Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach…
- Trial name
- NCT06182319
- Testing
- Gastrografin, Saline, SBO Treatment Without NG Tubes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Placenta; Implantation
MRI Screening of Placenta Adhesion Abnormalities
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during…
- Trial name
- DIANE (NCT04328532)
- Testing
- MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Glottic Web of Larynx, Laryngeal Stenosis
Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords
To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal…
- Conditions
- Glottic Web of Larynx, Laryngeal Stenosis, Glottic Carcinoma, Laryngeal Leucoplakia
- Trial name
- NCT05688488
- Testing
- Curcumin, Mitomycin-C
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University