Clinical trials: Tissue Adhesion
Neuropathy; Peripheral, Autonomic, in Diabetes Mellitus (Manifestation)
The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy
Exploring the relationship between serum VAP-1 and cardiovascular autonomic neuropathy in subjects with type 2 diabetes mellitus
- Trial name
- NCT01706289
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Endometriosis
Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier
Endometriosis is a common disease of women in the reproductive age and is an important cause for female infertility. Endometriosis is often associated with the development of adhesions which further compromises the fertility of…
- Trial name
- NCT02165917
- Testing
- Excision plus hyaluronic acid gel, Excision only
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Pius-Hospital Oldenburg
Kidney Failure, Chronic, Disorders Associated With Peritoneal Dialysis
Effect of Glucose Degradation Products (GDP) on Endothelial Dysfunction
The purpose of this study is to evaluate the effects of neutral pH and low glucose degradation product (GDP)-containing peritoneal dialysis fluid (PDF) on systemic inflammation and endothelial dysfunction markers in incident PD…
- Trial name
- NCT01315314
- Testing
- Balance, Fresenius Medical Care, Germany
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Kyungpook National University Hospital
Sickle Cell Disease
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to upregulate sickle red cell adhesion to laminin and endothelial cells in vitro.
- Trial name
- NCT02012777
- Testing
- propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Multiple Sclerosis
Analysis of Lymphocyte Cell Surface Adhesion Marker Expression in Natalizumab Population With Active Control
The purpose of the study is to research the association between receiving Tysabri® (natalizumab), interferon beta-1a, glatiramer acetate or not having any treatment for your MS and how it may or may not impact certain white blood…
- Trial name
- NCT01626248
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- John F. Foley, MD
Capsule Opacification, Tissue Adhesions
Evaluate Capsular Apposition to Intraocular Lens
In this study, the investigators examined the capsule-IOL interaction including anterior and posterior capsule adhesion, contact between posterior capsule and the posterior edge of intraocular lense (IOL), configuration of…
- Conditions
- Capsule Opacification, Tissue Adhesions, Aphakia - Lens Capsule Present, Opacification of Intraocular Lens
- Trial name
- NCT01605812
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Wenzhou Medical University
Vitreomacular Attachment, Vitreomacular Traction
A Safety and Efficacy Assessment of Resolvine for Treatment of Vitreomacular Attachment
This research is studying the effect that Resolvine injection will have on patients with vitreomacular adhesion.
- Conditions
- Vitreomacular Attachment, Vitreomacular Traction, Vitreomacular Adhesion
- Trial name
- NCT01966328
- Testing
- 36% Resolvine Intravitreal Injection, 9% Resolvine Intravitreal Injection
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Jeffrey S Heier
Sleep Apnea Syndromes, Hypertension
CPAP in SAHS Patients With Hypertension
Study objective: To assess the nocturnal changes in mechanosensitivity and chemosensitivity in hypertensive sleep apnea-hypopnea syndrome (SAHS) patients and in SAHS patients with isolated nocturnal hypertension.
- Trial name
- SAHS2-3 (NCT02398032)
- Testing
- CPAP nasal
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Hospital Universitario La Paz
Larynx Cancer, Larynx Carcinoma
An Investigation of Biomarker Candidate Molecules in Laryngeal Carcinoma
The aim of this study was to determine serum levels of VEGF, sVEGFR1, VEGFR2, IGFBP-3, angiogenin and endoglin in patients with larynx squamous cell carcinoma; investigate their association with clinical parameters and determine…
- Trial name
- NCT05217147
- Testing
- Obtaining blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Healthy
Nasal LPS Challenge in Healthy Volunteers
The purpose of this study is to develop a nasal challenge model that causes a mild degree of inflammation, without causing any pain or symptoms, but that allows us to measure a variety of proteins in nasal secretions which causes…
- Trial name
- NCT02284074
- Testing
- Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Uterine Fibroids, Infertility
a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic Myomectomy.
Premenopausal Women ages 18-42 will undergo a laparoscopic myomectomy. Prior to the myomectomy, adhesions will be assessed using a modified AFS scoring technique.
- Trial name
- VLocmyo (NCT01971060)
- Testing
- surgery utilizing V-Loc suture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Advanced Gynecologic Surgery Institute
Heart Failure
Effects of Chocolate in Patients With Chronic Heart Failure
The aim of the present study is to investigate whether in patients with chronic heart failure endothelial dysfunction and baroreceptor function is altered by ingestion of a flavonoid-rich dark chocolate in comparison to placebo…
- Trial name
- NCT00538941
- Testing
- Nestlé Noir intense 40 grx2
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- University of Zurich
Postoperative Adhesion, Peritoneal Adhesion, Nos
Efficacy of Sprayable PEG Barrier in Gynecologic Laparoscopy
The purpose of the study is to investigate whether sprayable PEG barrier is effective in reducing adhesions in laparoscopic gynecologic surgery.
- Trial name
- NCT01187680
- Testing
- Spraygel, Control
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Small Bowel Obstruction
A Procalcitonin-based Algorithm in Adhesion-related Small Bowel Obstruction
Adhesion-related small bowel obstruction is a common digestive emergency that can be managed either conservatively or surgically.
- Trial name
- ALPROC (NCT03905239)
- Testing
- algorithm
- Where
- France
- Volunteers
- 488 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Symptomatic Vitreomacular Adhesion (VMA)
A Retrospective Chart Review of Patients Treated With Ocriplasmin for Symptomatic VMA
The purpose of this study is to retrospectively review and further characterize anatomic and symptomatic changes over six months immediately following treatment of symptomatic vitreomacular adhesion (VMA) with JETREA®…
- Trial name
- OZONE (NCT02193945)
- Where
- 24 sites in United States
- Volunteers
- 134 people
- Sponsor
- ThromboGenics
Cancer
Study of a Focal Adhesion Kinase Inhibitor in Subjects With Solid Tumors
This study is a Phase I dose escalation study in subjects with solid tumors. Part 1 will identify the maximum tolerated dose (MTD) using a dose-escalation procedure.
- Trial name
- NCT01138033
- Testing
- GSK2256098
- Where
- 10 sites in Australia, France and 1 more
- Volunteers
- 74 people
- Sponsor
- GlaxoSmithKline
Non Hematologic Cancers, Metastatic Cancer
Phase I Dose Escalation Study of VS-4718 in Subjects With Metastatic Non-Hematologic Malignancies
This is a Phase I, open-label, multicenter, dose-escalation trial of VS-4718, a focal adhesion kinase inhibitor, in subjects with metastatic non-hematologic malignancies.
- Trial name
- NCT01849744
- Testing
- VS-4718
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Verastem, Inc.
Intra-Abdominal; Adhesion
Prediction of Intra-abdominal Adhesion Before CS
Recognition of intraabdominal adhesion before doing repeated cesarean section is helpful for the surgeon and patients.
- Trial name
- NCT03800511
- Testing
- sliding test
- Volunteers
- 27 people
- Sponsor
- Nahed allam
Idiopathic Pulmonary Fibrosis
Effect of Fostair® on Biomarkers of Platelet Adhesion in Idiopathic Pulmonary Fibrosis
The investigator has recently studied markers of platelet activation in idiopathic pulmonary fibrosis (IPF) and found that in IPF patients there is a significantly increased platelet reactivity when compared with controls which…
- Trial name
- NCT02048644
- Testing
- fostair
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Vitreomacular Adhesion
Intravitreal Gas for Vitreomacular Adhesion
Vitreomacular adhesion causes symptoms of blurry vision, distortion, and double vision. It is due to an abnormal separation of the vitreous gel from the surface of the retina and macula.
- Trial name
- RELEASE (NCT02001701)
- Testing
- Intravitreal Injection of sulfahexafluoride gas
- Where
- United States
- Sponsor
- Northern California Retina Vitreous Associates