Clinical trials: Tissue Adhesion
Post Operative Adhesions
Role of Hyaluronic Acid in the Prevention of Post-operative Adhesions: a RCT
The objective of study is to determine the effect of hyaluronic acid on the formation of post-operative adhesions. It will be a randomized control trial comparing the product against normal saline.
- Trial name
- HiB (NCT02790177)
- Testing
- Hyaluronic Acid, NORMAL SALINE
- Volunteers
- 150 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Intrauterine Synechiae, Tissue Adhesion, Surgery-Induced
The Efficacy and Safety of Medicurtain® in Patients With Hysteroscopy (Pivotal Study)
This study was designed to assess the safety and efficacy of MEDICURTAIN, an adhesion barrier in patients who underwent hysteroscopy with uterine polyp or endometrial myoma or missed abortion (uterine lesion suspected to be…
- Trial name
- NCT04638855
- Testing
- Medicurtain®
- Where
- South Korea
- Volunteers
- 223 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Uterine Fibroids, Fertility Disorders
Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery
The purpose of this study was to evaluate clinically the efficacy of the PREVADH® Film in the prevention of adhesions in gynaecologic surgery, and to assess post-operative complications related to adhesions and pregnancy rate…
- Trial name
- NCT01388907
- Testing
- Ringer lactate solution, Prevadh film
- Where
- 11 sites in France
- Volunteers
- 61 people
- Sponsor
- Medtronic - MITG
Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate
Lactobacillus Rhamnosus GG (ATCC 53103) in Mild-moderately Active UC Patients
This study is a randomized double-blind clinical trial that intends to evaluate the efficacy and safety of LGG administration at two different doses, for 1 month, in ulcerative colitis (UC) patients with mild-moderate disease…
- Trial name
- LGGinUC (NCT04102852)
- Testing
- Lactobacillus rhamnosus GG ATCC 53103
- Where
- Italy
- Volunteers
- 76 people
- Sponsor
- San Giovanni Addolorata Hospital
Infertility, Male
Reproductive Outcome After Sperm Selection for Intracytoplasmic Sperm Injection (ICSI) Using Zona Pellucida Proteins
The aim of this study is to analyze the effect of a sperm selection method by adhesion to partners' zona pellucida proteins on the assisted reproduction treatment (ART) outcome parameters.
- Trial name
- NCT05161247
- Testing
- Zona pellucida sperm selection, Conventional sperm selection, Intracytoplasmic Sperm Injection (ICSI)
- Where
- Bulgaria
- Volunteers
- 368 people
- Sponsor
- Nadezhda Women's Health Hospital
Tissue Adhesions
Cine-magnetic Resonance Imaging (MRI) Detecting Intra Abdominal Adhesions
Official title: Sensitivity and predictive value of functional cine magnetic resonance imaging (MRI) detecting intra-abdominal adhesions Background: Adhesions are a frequent problem in abdominal surgery.
- Trial name
- NCT00882167
- Testing
- CineMRI
- Where
- 5 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Healthy
Study to Assess Adhesion Quality and Wear of Placebo JNJ-35685-AAA-G-023 Transdermal System in Healthy Adults
The purpose of this study is to assess 3 different scoring systems to evaluate the adhesive quality of placebo (an inactive substance that is compared with a drug to test whether the drug has a real effect in a clinical trial])…
- Trial name
- NCT02221726
- Testing
- JNJ-35684-AAA-023: Size 1; small patch, JNJ-35684-AAA-023: Size 2; large patch
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Cesarean Section, Adhesions
Closure of Peritoneum at Cesarean Section and Postoperative Adhesion
Objective: To determine the effect of non-closure of the visceral and parietal peritoneum during Cesarean section on the formation of adhesions.
- Trial name
- cs adhesions (NCT01183000)
- Testing
- Closure of the peritoneum at cs
- Where
- 2 sites in Israel
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Barzilai Medical Center
Hepatitis C, Chronic, Hepacivirus
Adherence in Patients Receiving PegIntron/Rebetol for Hepatitis C in Conjunction With a Psychotherapy Support Program (Study P04252)
Several psychiatric adverse events (eg, depression, fatigue, psychoses, behavior troubles, anxiety, irritability, deteriorated concentration, and insomnia) that are likely to occur during the treatment course with PegIntron plus…
- Trial name
- NCT00723892
- Testing
- Peginterferon alfa-2b (PegIntron), Rebetol (Ribavirin), Psychotherapy support program
- Volunteers
- 614 people
- Sponsor
- Merck Sharp & Dohme LLC
Hyperemesis; Gravidarum, With Dehydration
Endothelial Dysfunction in Hyperemesis Gravidarum
The purpose of the study is to determine serum inflammatory adhesion molecules levels in hyperemesis gravidarum
- Trial name
- NCT02989337
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Thalassemia, Sickle Cell Disease
Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic blood and marrow transplantation remains the only viable cure for children who suffer from many serious non-malignant hematological diseases. Transplantation, however, carries a high risk of fatal complications.
- Conditions
- Thalassemia, Sickle Cell Disease, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
- Trial name
- NCT01319851
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Infertility, Abnormal Uterine Bleeding (AUB)
Evaluation of the Uterine Cavity After Operative Hysteroscopy
This study will focus on evaluation of the uterine cavity after operative hysteroscopy using three dimensional transvaginal ultrasonography and office hysteroscopy to detect and residual or recurrent abnormalities or intrauterine…
- Conditions
- Infertility, Abnormal Uterine Bleeding (AUB), Intrauterine Adhesion, Submucous Leiomyoma of Uterus
- Trial name
- NCT06924437
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Hysteroscopy, Intrauterine Adhesion
Early Outpatient Hysteroscopy Can Prevent Intrauterine Adhesion After Induced Abortion
Background: Intrauterine adhesions are a difficult clinical problem for reproductive infertility. The most common cause is uterine cavity surgery and post-abortion (including abortion and spontaneous abortion).
- Trial name
- NCT04166500
- Testing
- Hysteroscopy
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Retained Products of Conception
The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception
Retained product of conception (RPOC) is defined by abnormal trophoblastic persistence or retained placenta inside the uterus cavity after a pregnancy independently of the outcome. Untreated RPOC can compromise future fertility.
- Trial name
- NCT05085067
- Testing
- auto-crossed-linked hyaluronic acid gel
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Prepubertal Labial Adhesions
Treatment of Prepubertal Labial Adhesions
First-line treatment for labial adhesions in prepubertal girls has been topical estrogen. This study aims to evaluate an alternative and less costly option of treatment with potentially less side effects.
- Trial name
- NCT02218463
- Testing
- Estradiol cream 0.01%, Cetaphil
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Children's Mercy Hospital Kansas City
Caries Class II
Clinical Performance of Injection-Molding Vs. Incremental Packing of Resin Composite in Cavitated Posterior Teeth
The clinical performance of 2 bonding and composite packing techniques in the proximal cavities of permanent posterior teeth will be assessed.
- Trial name
- NCT05020093
- Testing
- Injection molding, Incremental packing
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Small Bowel Adhesion, Obstruction Bowel
Intestinal Obstruction Surgery. Acute Abdominal Pathology. №9:05/05/2026
Abstract and Study Objectives Adhesive small bowel obstruction (ASBO) is a common indication for surgical intervention. Intra-abdominal adhesions are the leading cause of small bowel obstruction, particularly in patients with a…
- Conditions
- Small Bowel Adhesion, Obstruction Bowel, Adhesiolysis, Laparoscopic Abdominal Surgeries
- Trial name
- AIO-S/AAP (NCT07905300)
- Testing
- surgical operation
- Where
- Kazakhstan
- Volunteers
- 1,500 people
- Sponsor
- Astana Medical University
Intrauterine Adhesion
Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion
This project will investigate the safety and effectiveness of human amniotic epithelial stem cells for treatment of severe refractory Asherman's syndrome.
- Trial name
- NCT03381807
- Testing
- hAESCs
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Intrauterine Adhesion
Postoperative Intermittent Intrauterine Balloon Dilatation Therapy.
In this prospective, randomized, controlled study, the investigators wish to determine the efficacy of intrauterine balloon (IUB) dilatation in the prevention of adhesion reformation when compared with the conventional management.
- Trial name
- NCT03131596
- Testing
- IUB dilatation therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fu Xing Hospital, Capital Medical University